Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Philip Koh"'
Autor:
Madeline H. Garvey, Tiffany Nash, J. Shane Kippenhan, Philip Kohn, Carolyn B. Mervis, Daniel P. Eisenberg, Jean Ye, Michael D. Gregory, Karen F. Berman
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Understanding neurogenetic mechanisms underlying neuropsychiatric disorders such as schizophrenia and autism is complicated by their inherent clinical and genetic heterogeneity. Williams syndrome (WS), a rare neurodevelopmental condition in
Externí odkaz:
https://doaj.org/article/c13498acbf25494da707b14cb8b122fd
Autor:
J. Shane Kippenhan, Michael D. Gregory, Tiffany Nash, Philip Kohn, Carolyn B. Mervis, Daniel P. Eisenberg, Madeline H. Garvey, Katherine Roe, Colleen A. Morris, Bhaskar Kolachana, Ariel M. Pani, Leah Sorcher, Karen F. Berman
Publikováno v:
Journal of Neurodevelopmental Disorders, Vol 15, Iss 1, Pp 1-13 (2023)
Abstract Background Williams syndrome (WS), a rare neurodevelopmental disorder caused by hemizygous deletion of ~ 25 genes from chromosomal band 7q11.23, affords an exceptional opportunity to study associations between a well-delineated genetic abnor
Externí odkaz:
https://doaj.org/article/3c215d21ffc540c18549592b98b88ec2
International business exchanges between and with Asian countries have increased enormously over the last few years. As a natural consequence, this has brought about an increasing number of trade disputes that are being resolved through arbitration a
FRET Assays for the Identification of C. albicans HSP90-Sba1 and Human HSP90α-p23 Binding Inhibitors
Publikováno v:
Pharmaceuticals, Vol 17, Iss 4, p 516 (2024)
Heat shock protein 90 (HSP90) is a critical target for anticancer and anti-fungal-infection therapies due to its central role as a molecular chaperone involved in protein folding and activation. In this study, we developed in vitro Förster Resonance
Externí odkaz:
https://doaj.org/article/c1fb5628e29d4878908c511c00118092
Autor:
Anna M.D. Watson, Melinda T. Coughlan, Catherine E. Winbanks, Merlin C. Thomas, Phillip Kantharidis, Mark E. Cooper, Karin Jandeleit-Dahm, Aaron McClelland, Wendy C. Burns, Philip Koh, Bo Wang
Publikováno v:
Diabetes
OBJECTIVE Progressive fibrosis in the diabetic kidney is driven and sustained by a diverse range of profibrotic factors. This study examines the critical role of microRNAs (miRNAs) in the regulation of the key fibrotic mediators, TGF-β1 and TGF-β2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74626f969f871dd0b4a8d1614b1919b2
http://europepmc.org/articles/PMC3012183
http://europepmc.org/articles/PMC3012183
Autor:
Michal Herman-Edelstein, Stephen M. Twigg, Philip Koh, Anna M.D. Watson, Karin Jandeleit-Dahm, Phillip Kantharidis, Mark E. Cooper, Gregory J. Goodall, Moin A. Saleem, Wendy C. Burns, Bo Wang
Publikováno v:
Diabetes
OBJECTIVE Increased deposition of extracellular matrix (ECM) within the kidney is driven by profibrotic mediators including transforming growth factor-β (TGF-β) and connective tissue growth factor (CTGF). We investigated whether some of their effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ea8451b856b4a50160c0f3ad2e8e390
http://europepmc.org/articles/PMC2889781
http://europepmc.org/articles/PMC2889781
Autor:
Stuart H. Orkin, Karin M.L. Gaensler, Merlin Crossley, Beng H. Chong, Robert Czoli, Jeremy Turner, Philip Koh, Andrew C. Perkins, Melissa L. Holmes, Yuko Fujiwara, Haidi Yang
Publikováno v:
Blood Cells, Molecules, and Diseases. 31:125-170
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c82dfa2a5acae6e72bb5b7fa6e8cc8cf
https://doi.org/10.1016/s1079-9796(03)00043-3
https://doi.org/10.1016/s1079-9796(03)00043-3
Autor:
Ka Sin Mak, Jose Perdomo, Philip Koh, Natalie A. Twine, Crisbel M. Artuz, Stuart H. Orkin, Stuart T. Fraser, Tzong-Tyng Hung, Alister P. W. Funnell, Richard C. M. Pearson, Marc R. Wilkins, Laura J. Norton, Jon Burdach, Carl Power, Andrew C. Perkins, Merlin Crossley, Kim S. Bell-Anderson
The CACCC-box binding protein erythroid Kruppel-like factor (EKLF/KLF1) is a master regulator that directs the expression of many important erythroid genes. We have previously shown that EKLF drives transcription of the gene for a second KLF, basic K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247c69184bbced390318f9c277594e33
https://europepmc.org/articles/PMC3434552/
https://europepmc.org/articles/PMC3434552/
Autor:
Merlin C. Thomas, Phillip Kantharidis, Catherine E. Winbanks, Rosemarie M. Carew, Bei Xu, Bo Wang, Radko Komers, Philip Koh, Paul Gregorevic, Mark E. Cooper, Michal Herman-Edelstein, Karin Jandeleit-Dahm
Publikováno v:
Journal of the American Society of Nephrology : JASN. 23(2)
Synthesis and deposition of extracellular matrix (ECM) within the glomerulus and interstitium characterizes renal fibrosis, but the mechanisms underlying this process are incompletely understood. The profibrotic cytokine TGF-β1 modulates the express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6290cc949067f489def61dec072589d7
https://pubmed.ncbi.nlm.nih.gov/22241893
https://pubmed.ncbi.nlm.nih.gov/22241893
Publikováno v:
Journal of hypertension. 27(7)
Background It has been suggested that aldosterone, with its known pro-inflammatory and profibrotic actions, may play a key role in the development and progression of atherosclerosis. Method In this study, the ability of aldosterone antagonism to redu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61001ee5085fdd13de1423c8c416c000
https://pubmed.ncbi.nlm.nih.gov/19381106
https://pubmed.ncbi.nlm.nih.gov/19381106