Zobrazeno 1 - 10
of 492
pro vyhledávání: '"Philip K. Maini"'
Autor:
Maximilian A. R. Strobl, Jill Gallaher, Jeffrey West, Mark Robertson-Tessi, Philip K. Maini, Alexander R. A. Anderson
Publikováno v:
Communications Medicine, Vol 2, Iss 1, Pp 1-18 (2022)
Strobl et al. develop an agent-based spatial model of drug resistance in tumour cells under adaptive therapy. Using this model, they investigate how the tumour’s spatial architecture impacts intratumoural competitive dynamics of drug-sensitive vs.
Externí odkaz:
https://doaj.org/article/6398a24b99384ae086f2c9a62bb96631
Publikováno v:
Rendiconti di Matematica e delle Sue Applicazioni, Vol 40, Iss 3-4, Pp 191-216 (2019)
Traveling waves are a near-ubiquitous phenomenon in mathematical biology, and have been studied in the context of embryonic development, cancer growth, wound healing, and epidemiology. Fisher's equation is the prototypical example of a problem that a
Externí odkaz:
https://doaj.org/article/0cd7d9f38cf949309735f021dc3c7e10
Publikováno v:
Open Biology, Vol 6, Iss 6 (2016)
Mathematical models are becoming increasingly integrated with experimental efforts in the study of biological systems. Collective cell migration in developmental biology is a particularly fruitful application area for the development of theoretical m
Externí odkaz:
https://doaj.org/article/a556ff44f1c04403a025ee0242d96720
Autor:
Jakub Köry, Vedang Narain, Bernadette J Stolz, Jakob Kaeppler, Bostjan Markelc, Ruth J Muschel, Philip K Maini, Joe M Pitt-Francis, Helen M Byrne
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 2, p e1011252 (2024)
Tumour angiogenesis leads to the formation of blood vessels that are structurally and spatially heterogeneous. Poor blood perfusion, in conjunction with increased hypoxia and oxygen heterogeneity, impairs a tumour's response to radiotherapy. The opti
Externí odkaz:
https://doaj.org/article/bc036081c6b94ada82eb532b05c135a7
Autor:
William Duncan Martinson, Rebecca McLennan, Jessica M Teddy, Mary C McKinney, Lance A Davidson, Ruth E Baker, Helen M Byrne, Paul M Kulesa, Philip K Maini
Publikováno v:
eLife, Vol 12 (2023)
Collective cell migration plays an essential role in vertebrate development, yet the extent to which dynamically changing microenvironments influence this phenomenon remains unclear. Observations of the distribution of the extracellular matrix (ECM)
Externí odkaz:
https://doaj.org/article/2dc117d3186148a4bb07444cc33ce442
Autor:
William S Hart, Sam Abbott, Akira Endo, Joel Hellewell, Elizabeth Miller, Nick Andrews, Philip K Maini, Sebastian Funk, Robin N Thompson
Publikováno v:
eLife, Vol 11 (2022)
The distribution of the generation time (the interval between individuals becoming infected and transmitting the virus) characterises changes in the transmission risk during SARS-CoV-2 infections. Inferring the generation time distribution is essenti
Externí odkaz:
https://doaj.org/article/0eb98f1e600a44449f9731b88eddd52d
Conditions for self-organisation via Turing's mechanism in biological systems represented by reaction-diffusion or reaction-cross-diffusion models have been extensively studied. Nonetheless, the impact of tissue stratification in such systems is unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::212db98156d6af024a2661e65ae6fb7a
https://doi.org/10.1101/2023.05.30.542795
https://doi.org/10.1101/2023.05.30.542795
Autor:
Alexander R.A. Anderson, Robert A. Gatenby, Michael B. Bonsall, Philip K. Maini, Kimberly A. Luddy, Mark Robertson-Tessi, Derek S. Park
Expanded parameter analysis for model parameter c. Greater T cell sensitivity to Tregs reduces the size of the Goldilocks Window.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e5708f5f1a2deca2ff090193b40b92e
https://doi.org/10.1158/0008-5472.22422086.v1
https://doi.org/10.1158/0008-5472.22422086.v1
Drug resistance is the single most important driver of cancer treatment failure for modern targeted therapies, and the dialog between tumor and stroma has been shown to modulate the response to molecularly targeted therapies through proliferative and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b1614e944987c66dc6aa651dc088788
https://doi.org/10.1158/0008-5472.c.6509177.v1
https://doi.org/10.1158/0008-5472.c.6509177.v1
Autor:
Alexander R.A. Anderson, Philip K. Maini, Robert A. Gatenby, Joel S. Brown, Mark Robertson-Tessi, Mehdi Damaghi, Yannick Viossat, Jeffrey West, Maximilian A.R. Strobl
Supplementary Material
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b2299941cde8c30ed70c190e96014b7
https://doi.org/10.1158/0008-5472.22427410.v1
https://doi.org/10.1158/0008-5472.22427410.v1