Zobrazeno 1 - 10
of 199
pro vyhledávání: '"Philip K Moore"'
Autor:
Emelyne Teo, Sudharshan Ravi, Diogo Barardo, Hyung-Seok Kim, Sheng Fong, Amaury Cazenave-Gassiot, Tsze Yin Tan, Jianhong Ching, Jean-Paul Kovalik, Markus R Wenk, Rudiyanto Gunawan, Philip K Moore, Barry Halliwell, Nicholas Tolwinski, Jan Gruber
Publikováno v:
eLife, Vol 8 (2019)
Alzheimer’s disease (AD) is the most common neurodegenerative disease affecting the elderly worldwide. Mitochondrial dysfunction has been proposed as a key event in the etiology of AD. We have previously modeled amyloid-beta (Aβ)-induced mitochond
Externí odkaz:
https://doaj.org/article/eb3eb4a1028f48789394b89e79678ebd
Autor:
Bedoor Qabazard, Samanza Ahmed, Ling Li, Volker M Arlt, Philip K Moore, Stephen R Stürzenbaum
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80135 (2013)
Exogenous hydrogen sulfide (H2S) administration and endogenous H2S metabolism were explored in the nematode C. elegans. Chronic treatment with a slow-releasing H2S donor, GYY4137, extended median survival by 17-23% and increased tolerance towards oxi
Externí odkaz:
https://doaj.org/article/a9489aeae4c74d0eaa9292ce1d843418
Autor:
Hai-Jian Sun, Si-Ping Xiong, Zhi-Yuan Wu, Lei Cao, Meng-Yuan Zhu, Philip K. Moore, Jin-Song Bian
Publikováno v:
Redox Biology, Vol 32, Iss , Pp - (2020)
Nitroxyl (HNO), one-electron reduced and protonated sibling of nitric oxide (NO), is a potential regulator of cardiovascular functions. It produces positive inotropic, lusitropic, myocardial anti-hypertrophic and vasodilator properties. Despite of th
Externí odkaz:
https://doaj.org/article/345742517431405296636d13d9f340c7
Publikováno v:
Redox Biology, Vol 15, Iss C, Pp 513-521 (2018)
Cisplatin is a major chemotherapeutic drug for solid tumors whereas it may lead to severe nephrotoxicity. Despite decades of efforts, effective therapies remain largely lacking for this disease. In the current research, we investigated the therapeuti
Externí odkaz:
https://doaj.org/article/9e0e77551d584b03b2ad52c5995980ba
Autor:
Zheng-Wei Lee, Xin-Yi Teo, Zhi J. Song, Dawn S. Nin, Wisna Novera, Bok A. Choo, Brian W. Dymock, Philip K. Moore, Ruby Y.-J. Huang, Lih-Wen Deng
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Slow and continuous release of H2S by GYY4137 has previously been demonstrated to kill cancer cells by increasing glycolysis and impairing anion exchanger and sodium/proton exchanger activity. This action is specific for cancer cells. The resulting l
Externí odkaz:
https://doaj.org/article/f4a5263f285b4a769eeb00d545b4e266
Autor:
Guoliang Meng, Yujiao Xiao, Yan Ma, Xin Tang, Liping Xie, Jieqiong Liu, Yue Gu, Ying Yu, Chung‐Min Park, Ming Xian, Xin Wang, Albert Ferro, Rui Wang, Philip K. Moore, Zhiren Zhang, Hong Wang, Yi Han, Yong Ji
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 9, Pp n/a-n/a (2016)
Background Hydrogen sulfide (H2S) is a gasotransmitter that regulates multiple cardiovascular functions. Krüppel‐like factor 5 (KLF5) exerts diverse functions in the cardiovascular system. Whether and how H2S regulates KLF5 in myocardial hypertrop
Externí odkaz:
https://doaj.org/article/b2431857513d4208b979587e4b2d1ebe
Autor:
Barry Halliwell, Li Fang Ng, Jan Gruber, Li Theng Ng, Richard Ming Yi Tang, Philip K. Moore, Diogo Barardo
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 6, Iss 1, Pp 1-14 (2020)
Caloric restriction (CR) is one of the most effective interventions to prolong lifespan and promote health. Recently, it has been suggested that hydrogen sulfide (H2S) may play a pivotal role in mediating some of these CR-associated benefits. While t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b71950a57a3aaa46fe6fac7cba8650
https://doaj.org/article/b0d8bd33beb746bda80e4ac101a4e47c
https://doaj.org/article/b0d8bd33beb746bda80e4ac101a4e47c
Autor:
A. Muthumala, Christopher Monkhouse, Rui Providência, Mark J. Earley, J Elliott, Ross J. Hunter, A Chow, Simon Sporton, N Mark, N Papageorgiou, Philip K. Moore, J Ramplin
Publikováno v:
European Heart Journal. 42
Introduction His bundle pacing (HBP) aims to deliver physiological activation of the ventricles via the native His-Purkinje conduction system. A challenge of HBP is the limited market of implantation tools, pacing leads and specifically designed paci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46ccca2bbd400fd7c362c2ccd9d911b1
https://doi.org/10.1093/eurheartj/ehab724.0676
https://doi.org/10.1093/eurheartj/ehab724.0676
Publikováno v:
Advances in experimental medicine and biology. 1315
Hydrogen sulfide (H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::09394acde8f2d9bbcec73210dfe838b4
https://pubmed.ncbi.nlm.nih.gov/34302690
https://pubmed.ncbi.nlm.nih.gov/34302690
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9789811609909
Hydrogen sulfide (H2S) is the "third gasotransmitter" recognized alongside nitric oxide (NO) and carbon monoxide (CO). H2S exhibits an array of biological effects in mammalian cells as revealed by studies showing important roles in the cardiovascular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b785e5158b631f1746f8cf9a5e0e602e
https://doi.org/10.1007/978-981-16-0991-6_5
https://doi.org/10.1007/978-981-16-0991-6_5
