Zobrazeno 1 - 10
of 492
pro vyhledávání: '"Philip K Maini"'
Autor:
Jakub Köry, Vedang Narain, Bernadette J Stolz, Jakob Kaeppler, Bostjan Markelc, Ruth J Muschel, Philip K Maini, Joe M Pitt-Francis, Helen M Byrne
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 2, p e1011252 (2024)
Tumour angiogenesis leads to the formation of blood vessels that are structurally and spatially heterogeneous. Poor blood perfusion, in conjunction with increased hypoxia and oxygen heterogeneity, impairs a tumour's response to radiotherapy. The opti
Externí odkaz:
https://doaj.org/article/bc036081c6b94ada82eb532b05c135a7
Autor:
William Duncan Martinson, Rebecca McLennan, Jessica M Teddy, Mary C McKinney, Lance A Davidson, Ruth E Baker, Helen M Byrne, Paul M Kulesa, Philip K Maini
Publikováno v:
eLife, Vol 12 (2023)
Collective cell migration plays an essential role in vertebrate development, yet the extent to which dynamically changing microenvironments influence this phenomenon remains unclear. Observations of the distribution of the extracellular matrix (ECM)
Externí odkaz:
https://doaj.org/article/2dc117d3186148a4bb07444cc33ce442
Autor:
William S Hart, Sam Abbott, Akira Endo, Joel Hellewell, Elizabeth Miller, Nick Andrews, Philip K Maini, Sebastian Funk, Robin N Thompson
Publikováno v:
eLife, Vol 11 (2022)
The distribution of the generation time (the interval between individuals becoming infected and transmitting the virus) characterises changes in the transmission risk during SARS-CoV-2 infections. Inferring the generation time distribution is essenti
Externí odkaz:
https://doaj.org/article/0eb98f1e600a44449f9731b88eddd52d
Publikováno v:
eLife, Vol 10 (2021)
Background: Understanding changes in infectiousness during SARS-COV-2 infections is critical to assess the effectiveness of public health measures such as contact tracing. Methods: Here, we develop a novel mechanistic approach to infer the infectious
Externí odkaz:
https://doaj.org/article/d4f984ae09af49b59872dcd23ee92ffb
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 1, p e1008055 (2021)
We introduce a hybrid two-dimensional multiscale model of angiogenesis, the process by which endothelial cells (ECs) migrate from a pre-existing vascular bed in response to local environmental cues and cell-cell interactions, to create a new vascular
Externí odkaz:
https://doaj.org/article/6011e689154b41e69bf15c3473e11809
Autor:
Derek S Park, Afua A Akuffo, David E Muench, H Leighton Grimes, Pearlie K Epling-Burnette, Philip K Maini, Alexander R A Anderson, Michael B Bonsall
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 4, p e1006913 (2019)
Clonal hematopoiesis of indeterminate potential (CHIP) is a recently identified process where older patients accumulate distinct subclones defined by recurring somatic mutations in hematopoietic stem cells. CHIP's implications for stem cell transplan
Externí odkaz:
https://doaj.org/article/d34cb7158def4953863dc0d44bdd6782
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 3, p e1006049 (2018)
The corneal micropocket angiogenesis assay is an experimental protocol for studying vessel network formation, or neovascularization, in vivo. The assay is attractive due to the ease with which the developing vessel network can be observed in the same
Externí odkaz:
https://doaj.org/article/7a94720943d44f388489afde2ee63191
Autor:
Oliver J Maclaren, Aimée Parker, Carmen Pin, Simon R Carding, Alastair J M Watson, Alexander G Fletcher, Helen M Byrne, Philip K Maini
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 7, p e1005688 (2017)
Our work addresses two key challenges, one biological and one methodological. First, we aim to understand how proliferation and cell migration rates in the intestinal epithelium are related under healthy, damaged (Ara-C treated) and recovering condit
Externí odkaz:
https://doaj.org/article/c51090bb4d624b438d20bf4f061ad52c
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 2, p e1005387 (2017)
The coordinated behaviour of populations of cells plays a central role in tissue growth and renewal. Cells react to their microenvironment by modulating processes such as movement, growth and proliferation, and signalling. Alongside experimental stud
Externí odkaz:
https://doaj.org/article/314e23be8a3946a9a3817c5eb1e1e26f
Spatial Metrics of Tumour Vascular Organisation Predict Radiation Efficacy in a Computational Model.
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 1, p e1004712 (2016)
Intratumoural heterogeneity is known to contribute to poor therapeutic response. Variations in oxygen tension in particular have been correlated with changes in radiation response in vitro and at the clinical scale with overall survival. Heterogeneit
Externí odkaz:
https://doaj.org/article/5076b210985a4f40822e6c0ea5639281