AP-1/c-Fos supports SIV and HIV-1 latency in CD4 T cells infected in vivo

Autor: Viviana Cobos Jiménez, Aviva Geretz, Andrey Tokarev, Philip K. Ehrenberg, Selase Deletsu, Kawthar Machmach, Prakriti Mudvari, J. Natalie Howard, Amanda Zelkoski, Dominic Paquin-Proulx, Gregory Q. Del Prete, Caroline Subra, Eli A. Boritz, Alberto Bosque, Rasmi Thomas, Diane L. Bolton

Publikováno v: iScience, Vol 26, Iss 10, Pp 108015- (2023)

Summary: Persistent HIV-1 reservoirs of infected CD4 T cells are a major barrier to HIV-1 cure, although the mechanisms by which they are established and maintained in vivo remain poorly characterized. To elucidate host cell gene expression patterns

Externí odkaz: https://doaj.org/article/610f567e63764468b36e1cbb767d05df

HLA-B*57 and B*58 Associate with Predictors of Reservoir Size in an Acutely Treated HIV Cohort

Autor: Shida Shangguan, Philip K. Ehrenberg, Aviva Geretz, Lauryn Butler, Suteeraporn Pinyakorn, Somchai Sriplienchan, Carlo Sacdalan, Nitiya Chomchey, Nittaya Phanuphak, Sodsai Tovanabutra, Sandhya Vasan, Denise Hsu, Rasmi Thomas

Publikováno v: AIDS Research and Human Retroviruses. 39:114-118

Much has been learnt about the role of HLA alleles during natural infection of HIV-1, but far less is known about their role in people living with HIV (PLWH) on suppressive antiretroviral therapy (ART). In this study we used variable selection to ide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a7385e6c64d383593446e626225dddf
https://doi.org/10.1089/aid.2022.0082

Long-term antiretroviral therapy initiated in acute HIV infection prevents residual dysfunction of HIV-specific CD8+ T cells

Autor: Hiroshi Takata, Juyeon C. Kakazu, Julie L. Mitchell, Eugene Kroon, Donn J. Colby, Carlo Sacdalan, Hongjun Bai, Philip K. Ehrenberg, Aviva Geretz, Supranee Buranapraditkun, Suteeraporn Pinyakorn, Jintana Intasan, Somporn Tipsuk, Duanghathai Suttichom, Peeriya Prueksakaew, Thep Chalermchai, Nitiya Chomchey, Nittaya Phanuphak, Mark de Souza, Nelson L. Michael, Merlin L. Robb, Elias K. Haddad, Trevor A Crowell, Sandhya Vasan, Victor G. Valcour, Daniel C. Douek, Rasmi Thomas, Morgane Rolland, Nicolas Chomont, Jintanat Ananworanich, Lydie Trautmann, Nipat Teeratakulpisarn, Supanit Pattanachaiwit, Somchai Sriplienchan, Ponpen Tantivitayakul, Ratchapong Kanaprach, Kiat Ruxrungtham, Netsiri Dumrongpisutikul, Ponlapat Rojnuckarin, Suthat Chottanapund, Kultida Poltavee, Tassanee Luekasemsuk, Hathairat Savadsuk, Suwanna Puttamsawin, Khunthalee Benjapornpong, Nisakorn Ratnaratorn, Kamonkan Tangnaree, Chutharat Munkong, Rommanus Thaimanee, Patcharin Eamyoung, Sasiwimol Ubolyam, Sukalya Lerdlum, Sopark Manasnayakorn, Rugsun Rerknimitr, Sunee Sirivichayakul, Phandee Wattanaboonyongcharoen, Jessica Cowden, Alexandra Schuetz, Siriwat Akapirat, Nampueng Churikanont, Saowanit Getchalarat, Denise Hsu, Ellen Turk, Oratai Butterworth, Mark Milazzo, Leigh Anne Eller, Julie Ake, Serena Spudich, CAPT Lawrence Fox, Silvia Ratto-Kim, Victor DeGruttola, Yotin Chinvarun, Pasiri Sithinamsuwan, James Fletcher, Bruce Shiramizu

Publikováno v: EBioMedicine, 84:104253. Elsevier BV

Background: Harnessing CD8+ T cell responses is being explored to achieve HIV remission. Although HIV-specific CD8+ T cells become dysfunctional without treatment, antiretroviral therapy (ART) partially restores their function. However, the extent of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74ee00d0a89a3c191cfdc203a7d62105
https://doi.org/10.1016/j.ebiom.2022.104253

Monocyte-derived transcriptome signature indicates antibody-dependent cellular phagocytosis as a potential mechanism of vaccine-induced protection against HIV-1

Autor: Rasmi Thomas, Daniel C. Douek, Krystelle Nganou-Makamdop, Philip K. Ehrenberg, Peter B. Gilbert, Aviva Geretz, Eric Lewitus, Slim Fourati, Lauren Yum, Punnee Pitisuttithum, Sheetal Sawant, Sandhya Vasan, LaTonya D. Williams, Nelson L. Michael, Supachai Rerks-Ngarm, Sorachai Nitayaphan, Gautam Kundu, Suwat Chariyalertsak, Kelly May, Morgane Rolland, Shida Shangguan, Georgia D. Tomaras

Publikováno v: eLife, Vol 10 (2021)
eLife

A gene signature was previously found to be correlated with mosaic adenovirus 26 vaccine protection in simian immunodeficiency virus and simian-human immunodeficiency virus challenge models in non-human primates. In this report, we investigated the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cec297b2032ff1139f28ada6872d72f
https://elifesciences.org/articles/69577

Monocyte-derived transcriptome signature indicates antibody-dependent cellular phagocytosis as the primary mechanism of vaccine-induced protection against HIV-1

Autor: Georgia D. Tomaras, Sorachai Nitayaphan, Daniel C. Douek, Gautam Kundu, Sheetal Sawant, Rasmi Thomas, Punnee Pitisuttithum, Sandhya Vasan, Peter B. Gilbert, Shida Shangguan, Eric Lewitus, Slim Fourati, Philip K. Ehrenberg, Supachai Rerks-Ngarm, Lauren Yum, Nelson L. Michael, Krystelle Nganou-Makamdop, LaTonya D. Williams, Aviva Geretz, Suwat Chariyalertsak, Kelly May, Morgane Rolland

A gene signature previously correlated with mosaic adenovirus 26 vaccine protection in simian immunodeficiency virus (SIV) and SHIV challenge models in non-human primates (NHP). In this report we investigated presence of this signature as a correlate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b7757c06a4237dcc7ff5cfd6c4492e7b
https://doi.org/10.1101/2021.05.12.443737