Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Philip J. Vernon"'
Autor:
Philip J Vernon, Leasha J Schaub, Jurandir J Dallelucca, Anthony E Pusateri, Forest R Sheppard
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0146105 (2015)
BACKGROUND:Maladaptive immune responses, particularly cytokine and chemokine-driven, are a significant contributor to the deleterious inflammation present in many types of injury and infection. Widely available applications to rapidly assess individu
Externí odkaz:
https://doaj.org/article/116f52c48fdf4a8bb51d7145d8f92c25
Autor:
Forest R. Sheppard, Philip J. Vernon, Douglas K. Tadaki, Jurandir J. Dallelucca, Sarah Reyna, R. Madelaine Paredes
Publikováno v:
International Immunopharmacology. 54:221-225
Severe trauma initiates a systemic inflammatory cascade and that involves early activation of complement and cleavage of C5 into C5a (anaphylatoxin) and C5b (C5b-9 membrane attack complex). We examined activation of C5 in non-human primate (NHP) mode
Autor:
Forest R. Sheppard, Antoni R. Macko, Jacob J. Glaser, Douglas K. Tadaki, Ruth Madelaine Paredes, Anthony E. Pusateri, Sylvain Cardin, Alexander J. Burdette, Philip J. Vernon, Craig A Koeller
Publikováno v:
Shock (Augusta, Ga.). 49(2)
Background We endeavored to develop clinically translatable nonhuman primate (NHP) models of severe polytraumatic hemorrhagic shock. Methods NHPs were randomized into five severe pressure-targeted hemorrhagic shock (PTHS) ± additional injuries scena
Autor:
Philip J. Vernon, Amanda J. Sooter, Leasha J. Schaub, Anthony E. Pusateri, Forest R. Sheppard, Jacob J. Glaser, Heather M. Grossman, Ruth Madelaine Paredes
Publikováno v:
Shock (Augusta, Ga.). 46(3 Suppl 1)
Neutrophilic inflammation is a mediator of morbidity and mortality in response to hemorrhagic shock. Although injury-induced neutrophil margination has long been observed, the nature of neutrophils' role in the "second hit" paradigm remains to be ful
Autor:
Forest R. Sheppard, Leasha J. Schaub, Philip J. Vernon, Jurandir J. Dallelucca, Anthony E. Pusateri
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0146105 (2015)
PLoS ONE
PLoS ONE
Background Maladaptive immune responses, particularly cytokine and chemokine-driven, are a significant contributor to the deleterious inflammation present in many types of injury and infection. Widely available applications to rapidly assess individu
Publikováno v:
The Journal of Immunology. 196:51.18-51.18
Background Trauma is a leading cause of mortality, with those surviving their initial injuries remaining at risk for death due to deleterious inflammation. Preclinical investigations of immunomodulatory therapeutics are hindered by the limitations of
Autor:
Wenqian Wang, Thorne Stephen, Philip J Vernon, Michael T. Lotze, Padmavathi Sampath, Guanqiao Li, Xiaoyan Liang
Publikováno v:
Journal for Immunotherapy of Cancer
HMGB1, an evolutionarily ancient and abundant DNA-binding protein within the nucleus, acts as a Damage Associated Molecular Pattern (DAMP) molecule extracellularly to promote immunity. During both cellular stress and immune cell activation, it is tra