Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Philip J. Uren"'
Autor:
Mohammad Abbasi, Andrew D. Smith, Harish Swaminathan, Peer Sangngern, Amanda Douglas, Alan Horsager, Douglas T. Carrell, Philip J. Uren
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-12 (2018)
Abstract Background Several independent research groups have shown that alterations in human sperm methylation profiles correlate with decreased fecundity and an increased risk of poor embryo development. Moving these initial findings from the lab in
Externí odkaz:
https://doaj.org/article/af93882eebc24f51a239f5830d32ea80
Autor:
Hanane Ennajdaoui, Jonathan M. Howard, Timothy Sterne-Weiler, Fereshteh Jahanbani, Doyle J. Coyne, Philip J. Uren, Marija Dargyte, Sol Katzman, Jolene M. Draper, Andrew Wallace, Oscar Cazarez, Suzanne C. Burns, Mei Qiao, Lindsay Hinck, Andrew D. Smith, Masoud M. Toloue, Benjamin J. Blencowe, Luiz O.F. Penalva, Jeremy R. Sanford
Publikováno v:
Cell Reports, Vol 15, Iss 9, Pp 1876-1883 (2016)
Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) expression correlates with malignancy, but its role(s) in pathogenesis remains enigmatic. We interrogated the IGF2BP3-RNA interaction network in pancreatic ductal adenocarcinoma (PDAC) cel
Externí odkaz:
https://doaj.org/article/4c64e93800e542b284ebe625acd620b5
Autor:
Cristina M. Ramírez, Chin Sheng Lin, Kotb Abdelmohsen, Leigh Goedeke, Je-Hyun Yoon, Julio Madrigal-Matute, Jose L. Martin-Ventura, Dat T. Vo, Philip J. Uren, Luiz O. Penalva, Myriam Gorospe, Carlos Fernández-Hernando
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 6, Pp 1066-1076 (2014)
ABCA1 is a major regulator of cellular cholesterol efflux and plasma HDL biogenesis. Even though the transcriptional activation of ABCA1 is well established, the posttranscriptional regulation of ABCA1 expression is poorly understood. Here, we invest
Externí odkaz:
https://doaj.org/article/796103e7d8ea4b5eae8516c0e40c2d78
Autor:
Andrew D. Smith, Mohammad Abbasi, Philip J. Uren, Harish Swaminathan, Douglas T. Carrell, Amanda Douglas, Alan Horsager, Peer Sangngern
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-12 (2018)
Background Several independent research groups have shown that alterations in human sperm methylation profiles correlate with decreased fecundity and an increased risk of poor embryo development. Moving these initial findings from the lab into a clin
Autor:
Acarizia Eduardo da Silva, Mei Qiao, Zhi-Min Yuan, Dat T. Vo, Alexander J.R. Bishop, Aparna Gorthi, Sonal S. Tonapi, Philip J. Uren, Luiz O. F. Penalva, Suzanne C. Burns, Patrícia R. Araújo
Publikováno v:
The American Journal of Pathology. 186:2271-2278
The conserved RNA-binding protein Musashi1 (MSI1) has been characterized as a stem cell marker, controlling the balance between self-renewal and differentiation and as a key oncogenic factor in numerous solid tumors, including glioblastoma. To explor
Autor:
Andrew D. Smith, Mei Qiao, Myriam Gorospe, Helder I. Nakaya, Kotb Abdelmohsen, Patrícia R. Araújo, Jernej Ule, Raquel de Sousa Abreu, Caspar D. Kühnöl, Emad Bahrami-Samani, Philip J. Uren, Jennifer L. Martindale, Bruna R. Correa, Rebecca Pötschke, Dat T. Vo, Luiz O. F. Penalva, Suzanne C. Burns
Publikováno v:
Molecular and Cellular Biology. 35:2965-2978
The conserved RNA-binding protein Musashi1 (MSI1) has emerged as a key oncogenic factor in numerous solid tumors, including glioblastoma. However, its mechanism of action has not yet been established comprehensively. To identify its target genes comp
Autor:
Patrícia R. Araújo, Dat T. Vo, Andrew D. Smith, Emad Bahrami-Samani, Christine Vogel, Philip J. Uren, Luiz O. F. Penalva
Publikováno v:
Wiley Interdisciplinary Reviews: RNA. 6:291-310
Co- and post-transcriptional regulation of gene expression is complex and multifaceted, spanning the complete RNA lifecycle from genesis to decay. High-throughput profiling of the constituent events and processes is achieved through a range of techno
Publikováno v:
Nucleic Acids Research
High-throughput protein-RNA interaction data generated by CLIP-seq has provided an unprecedented depth of access to the activities of RNA-binding proteins (RBPs), the key players in co- and post-transcriptional regulation of gene expression. Motif di
Motivation Global analysis of translation regulation has recently been enabled by the development of Ribosome Profiling, or Ribo-seq, technology. This approach provides maps of ribosome activity for each expressed gene in a given biological sample. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01005bc08fea5be40dc043a7d85e34c1
https://europepmc.org/articles/PMC5860393/
https://europepmc.org/articles/PMC5860393/
Autor:
Dat T. Vo, Philip J. Uren, Leigh Goedeke, Luiz O. F. Penalva, José Luis Martín-Ventura, Carlos Fernández-Hernando, Chin Sheng Lin, Cristina M. Ramírez, Julio Madrigal-Matute, Myriam Gorospe, Je-Hyun Yoon, Kotb Abdelmohsen
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 6, Pp 1066-1076 (2014)
ABCA1 is a major regulator of cellular cholesterol efflux and plasma HDL biogenesis. Even though the transcriptional activation of ABCA1 is well established, the posttranscriptional regulation of ABCA1 expression is poorly understood. Here, we invest