Výsledky vyhledávání - "Philip J. Tofilon"

Akademický článek

Targeting PRMT5 enhances the radiosensitivity of tumor cells grown in vitro and in vivo

Autor: Charlotte Degorre, Steven Lohard, Christina N. Bobrek, Komal N. Rawal, Skyler Kuhn, Philip J. Tofilon

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)

Abstract PRMT5 is a widely expressed arginine methyltransferase that regulates processes involved in tumor cell proliferation and survival. In the study described here, we investigated whether PRMT5 provides a target for tumor radiosensitization. Kno

Externí odkaz: https://doaj.org/article/1277a2b62112434899d4c69804c491f9

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Akademický článek

MGMT inhibition regulates radioresponse in GBM, GSC, and melanoma

Autor: Hong Shik Yun, Tamalee R. Kramp, Kamalakannan Palanichamy, Philip J. Tofilon, Kevin Camphausen

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)

Abstract Radiotherapy is the standard treatment for glioblastoma (GBM), but the overall survival rate for radiotherapy treated GBM patients is poor. The use of adjuvant and concomitant temozolomide (TMZ) improves the outcome; however, the effectivene

Externí odkaz: https://doaj.org/article/a2cb9017ba34447e85204e2424d1bc93

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Akademický článek

Glioblastoma cells have increased capacity to repair radiation-induced DNA damage after migration to the olfactory bulb

Autor: Charlotte Degorre, Ian C. Sutton, Stacey L. Lehman, Uma T. Shankavaram, Kevin Camphausen, Philip J. Tofilon

Publikováno v: Cancer Cell International, Vol 22, Iss 1, Pp 1-13 (2022)

Abstract Background The invasive nature of GBM combined with the diversity of brain microenvironments creates the potential for a topographic heterogeneity in GBM radioresponse. Investigating the mechanisms responsible for a microenvironment-induced

Externí odkaz: https://doaj.org/article/acc01da916514c0a8e8f39bc81e249be

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Akademický článek

CX-5461 induces radiosensitization through modification of the DNA damage response and not inhibition of RNA polymerase I

Autor: Stacey L. Lehman, Kayla R. Schwartz, Shrankhla Maheshwari, Kevin Camphausen, Philip J. Tofilon

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)

Abstract Increased ribosome biogenesis is a distinguishing feature of cancer cells, and small molecule inhibitors of ribosome biogenesis are currently in clinical trials as single agent therapy. It has been previously shown that inhibiting ribosome b

Externí odkaz: https://doaj.org/article/963dcbc4505c4f46bc7e5e3ab7dd2d8c

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Akademický článek

The Brain Microenvironment Preferentially Enhances the Radioresistance of CD133+ Glioblastoma Stem-like Cells

Autor: Muhammad Jamal, Barbara H. Rath, Patricia S. Tsang, Kevin Camphausen, Philip J. Tofilon

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 2, Pp 150-158 (2012)

Brain tumor xenografts initiated from glioblastoma (GBM) CD133+ tumor stem-like cells (TSCs) are composed of TSC and non-TSC subpopulations, simulating the phenotypic heterogeneity of GBMs in situ. Given that the discrepancies between the radiosensit

Externí odkaz: https://doaj.org/article/0f54d7ffa3094c72b015edfc9ba63d10

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Akademický článek

Activation of the Unfolded Protein Response Contributes toward the Antitumor Activity of Vorinostat

Autor: Soumen Kahali, Bhaswati Sarcar, Bin Fang, Eli S. Williams, John M. Koomen, Philip J. Tofilon, Prakash Chinnaiyan

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 12, Iss 1, Pp 80-86 (2010)

Histone deacetylase (HDAC) inhibitors represent an emerging class of anticancer agents progressing through clinical trials. Although their primary target is thought to involve acetylation of core histones, several nonhistone substrates have been iden

Externí odkaz: https://doaj.org/article/3f3d803b028f4ec4b5fe652865305d84

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