Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Philip J. M. Brouwer"'
Autor:
Adam J. Ronk, Nicole M. Lloyd, Min Zhang, Caroline Atyeo, Hailee R. Perrett, Chad E. Mire, Kathryn M. Hastie, Rogier W. Sanders, Philip J. M. Brouwer, Erica Olmann Saphire, Andrew B. Ward, Thomas G. Ksiazek, Juan Carlos Alvarez Moreno, Harshwardhan M. Thaker, Galit Alter, Sunny Himansu, Andrea Carfi, Alexander Bukreyev
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Lassa virus is a member of the Arenaviridae family, which causes human infections ranging from asymptomatic to severe hemorrhagic disease with a high case fatality rate. We have designed and generated lipid nanoparticle encapsulated, modifie
Externí odkaz:
https://doaj.org/article/4afd193033d54672afc7fc5b00f7b333
Autor:
Kwinten Sliepen, Laura Radić, Joan Capella-Pujol, Yasunori Watanabe, Ian Zon, Ana Chumbe, Wen-Hsin Lee, Marlon de Gast, Jelle Koopsen, Sylvie Koekkoek, Iván del Moral-Sánchez, Philip J. M. Brouwer, Rashmi Ravichandran, Gabriel Ozorowski, Neil P. King, Andrew B. Ward, Marit J. van Gils, Max Crispin, Janke Schinkel, Rogier W. Sanders
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
E1E2 spike on the hepatitis C virion is an important target for vaccine design. Here, the authors permute the subunits to generate E2E1 immunogens and show that mosaic nanoparticles displaying different E2E1 antigens elicit cross-neutralizing antibod
Externí odkaz:
https://doaj.org/article/4bc99bb0318e4c848fb64b60030bf5d0
Autor:
Mathieu Claireaux, Tom G. Caniels, Marlon de Gast, Julianna Han, Denise Guerra, Gius Kerster, Barbera D. C. van Schaik, Aldo Jongejan, Angela I. Schriek, Marloes Grobben, Philip J. M. Brouwer, Karlijn van der Straten, Yoann Aldon, Joan Capella-Pujol, Jonne L. Snitselaar, Wouter Olijhoek, Aafke Aartse, Mitch Brinkkemper, Ilja Bontjer, Judith A. Burger, Meliawati Poniman, Tom P. L. Bijl, Jonathan L. Torres, Jeffrey Copps, Isabel Cuella Martin, Steven W. de Taeye, Godelieve J. de Bree, Andrew B. Ward, Kwinten Sliepen, Antoine H. C. van Kampen, Perry D. Moerland, Rogier W. Sanders, Marit J. van Gils
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
To fully understand the potential shortcomings of SARS-CoV-2 vaccination, it is necessary to delineate the properties of the antibodies elicited, during immunization, and also infection. Through investigation of the SARS-CoV-2 spike-reactive B cell r
Externí odkaz:
https://doaj.org/article/86312e11f65b467f911c74e87e292a4a
Autor:
Mitch Brinkkemper, Philip J. M. Brouwer, Pauline Maisonnasse, Marloes Grobben, Tom G. Caniels, Meliawati Poniman, Judith A. Burger, Ilja Bontjer, Melissa Oomen, Joey H. Bouhuijs, Cynthia A. van der Linden, Julien Villaudy, Yme U. van der Velden, Kwinten Sliepen, Marit J. van Gils, Roger Le Grand, Rogier W. Sanders
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-6 (2021)
Abstract The emergence of SARS-CoV-2 variants that are more resistant to antibody-mediated neutralization pose a new hurdle in combating the COVID-19 pandemic. Although vaccines based on the original Wuhan sequence have been shown to be effective at
Externí odkaz:
https://doaj.org/article/39e9afe868e64efa8901980882397e7e
Autor:
Victor Yin, Szu-Hsueh Lai, Tom G. Caniels, Philip J. M. Brouwer, Mitch Brinkkemper, Yoann Aldon, Hejun Liu, Meng Yuan, Ian A. Wilson, Rogier W. Sanders, Marit J. van Gils, Albert J. R. Heck
Publikováno v:
ACS Central Science, Vol 7, Iss 11, Pp 1863-1873 (2021)
Externí odkaz:
https://doaj.org/article/e0416f72c914405493ac76f84d0a66c4
Autor:
Pauline Maisonnasse, Yoann Aldon, Aurélien Marc, Romain Marlin, Nathalie Dereuddre-Bosquet, Natalia A. Kuzmina, Alec W. Freyn, Jonne L. Snitselaar, Antonio Gonçalves, Tom G. Caniels, Judith A. Burger, Meliawati Poniman, Ilja Bontjer, Virginie Chesnais, Ségolène Diry, Anton Iershov, Adam J. Ronk, Sonia Jangra, Raveen Rathnasinghe, Philip J. M. Brouwer, Tom P. L. Bijl, Jelle van Schooten, Mitch Brinkkemper, Hejun Liu, Meng Yuan, Chad E. Mire, Mariëlle J. van Breemen, Vanessa Contreras, Thibaut Naninck, Julien Lemaître, Nidhal Kahlaoui, Francis Relouzat, Catherine Chapon, Raphaël Ho Tsong Fang, Charlene McDanal, Mary Osei-Twum, Natalie St-Amant, Luc Gagnon, David C. Montefiori, Ian A. Wilson, Eric Ginoux, Godelieve J. de Bree, Adolfo García-Sastre, Michael Schotsaert, Lynda Coughlan, Alexander Bukreyev, Sylvie van der Werf, Jérémie Guedj, Rogier W. Sanders, Marit J. van Gils, Roger Le Grand
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Monoclonal antibodies show great promise in treating Covid-19 patients. Here, Maisonnasse, Aldon and colleagues report pre-clinical results for COVA1-18 and demonstrate that it reduces viral infectivity in three animal models with over 95% efficacy i
Externí odkaz:
https://doaj.org/article/cb63fd675fbc4192b0ac21fa54904b08
Autor:
Kwinten Sliepen, Edith Schermer, Ilja Bontjer, Judith A. Burger, Réka Felfödiné Lévai, Philipp Mundsperger, Philip J. M. Brouwer, Monica Tolazzi, Atilla Farsang, Dietmar Katinger, John P. Moore, Gabriella Scarlatti, Robin J. Shattock, Quentin J. Sattentau, Rogier W. Sanders
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-8 (2021)
Abstract The immunogenicity of HIV-1 envelope (Env) trimers is generally poor. We used the clinically relevant ConM SOSIP trimer to compare the ability of different adjuvants (squalene emulsion, ISCOMATRIX, GLA-LSQ, and MPLA liposomes) to support neu
Externí odkaz:
https://doaj.org/article/3493c21b5fee4dc2a902a4cfd21185c1
Autor:
Philip J. M. Brouwer, Aleksandar Antanasijevic, Marlon de Gast, Joel D. Allen, Tom P. L. Bijl, Anila Yasmeen, Rashmi Ravichandran, Judith A. Burger, Gabriel Ozorowski, Jonathan L. Torres, Celia LaBranche, David C. Montefiori, Rajesh P. Ringe, Marit J. van Gils, John P. Moore, Per Johan Klasse, Max Crispin, Neil P. King, Andrew B. Ward, Rogier W. Sanders
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-14 (2021)
Abstract The HIV-1 envelope glycoprotein trimer is poorly immunogenic because it is covered by a dense glycan shield. As a result, recombinant Env glycoproteins generally elicit inadequate antibody levels that neutralize clinically relevant, neutrali
Externí odkaz:
https://doaj.org/article/6d2ce266cff0455eb80fcc32049d700d
Autor:
Sabrina Mariotti, Maria Vincenza Chiantore, Raffaela Teloni, Angelo Iacobino, Antonio Capocefalo, Zuleika Michelini, Martina Borghi, Melissa Baggieri, Antonella Marchi, Paola Bucci, Silvia Gioacchini, Raffaele D’Amelio, Philip J. M. Brouwer, Silvia Sandini, Chiara Acchioni, Marco Sgarbanti, Antonio Di Virgilio, Felicia Grasso, Andrea Cara, Donatella Negri, Fabio Magurano, Paola Di Bonito, Roberto Nisini
Publikováno v:
Biomedicines, Vol 11, Iss 2, p 610 (2023)
The emergence of the new pathogen SARS-CoV-2 determined a rapid need for monoclonal antibodies (mAbs) to detect the virus in biological fluids as a rapid tool to identify infected individuals to be treated or quarantined. The majority of commercially
Externí odkaz:
https://doaj.org/article/11a145eeb68346068f8c5df403b3c9e3
Autor:
Philip J. M. Brouwer, Aleksandar Antanasijevic, Zachary Berndsen, Anila Yasmeen, Brooke Fiala, Tom P. L. Bijl, Ilja Bontjer, Jacob B. Bale, William Sheffler, Joel D. Allen, Anna Schorcht, Judith A. Burger, Miguel Camacho, Daniel Ellis, Christopher A. Cottrell, Anna-Janina Behrens, Marco Catalano, Iván del Moral-Sánchez, Thomas J. Ketas, Celia LaBranche, Marit J. van Gils, Kwinten Sliepen, Lance J. Stewart, Max Crispin, David C. Montefiori, David Baker, John P. Moore, Per Johan Klasse, Andrew B. Ward, Neil P. King, Rogier W. Sanders
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nanoparticles are a promising approach to increase immunogenicity of protein antigens for vaccines. Here, Brouwer et al. design self-assembling, two-component protein NPs that present native-like SOSIP trimers of HIV envelope protein and determine im
Externí odkaz:
https://doaj.org/article/3f361bf123134e9fb806b778a2f53c71