Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Philip J. Luthert"'
Autor:
Matilde V. Neto, Giulia De Rossi, Bruce A. Berkowitz, Miguel C. Seabra, Philip J. Luthert, Clare E. Futter, Thomas Burgoyne
Publikováno v:
Cells, Vol 13, Iss 13, p 1100 (2024)
The retinal pigment epithelium (RPE) is an essential component of the retina that plays multiple roles required to support visual function. These include light onset- and circadian rhythm-dependent tasks, such as daily phagocytosis of photoreceptor o
Externí odkaz:
https://doaj.org/article/c2b2460d89ce4685a5d3ae2bdde2d5da
Autor:
Thomas Sevrin, Lisa Strasser, Camille Ternet, Philipp Junk, Miriam Caffarini, Stella Prins, Cian D’Arcy, Simona Catozzi, Giorgio Oliviero, Kieran Wynne, Christina Kiel, Philip J. Luthert
Publikováno v:
iScience, Vol 26, Iss 2, Pp 105931- (2023)
Summary: Cellular utilization of available energy flows to drive a multitude of forms of cellular “work” is a major biological constraint. Cells steer metabolism to address changing phenotypic states but little is known as to how bioenergetics co
Externí odkaz:
https://doaj.org/article/6de2b23fa3ec46d599bb05156eb3e002
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 6, Iss 1, Pp 1-11 (2020)
Abstract Age-related macular degeneration (AMD) is one of the commonest causes of sight loss in the elderly population and to date there is no intervention that slows or prevents early AMD disease progressing to blinding neovascularization or geograp
Externí odkaz:
https://doaj.org/article/d8745f6560644aabb7a1696f079360c3
Autor:
Anna M. Rose, Rong Luo, Utsav K. Radia, Helen Kalirai, Sophie Thornton, Philip J. Luthert, Channa N. Jayasena, David H. Verity, Sarah E. Coupland, Geoffrey E. Rose
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-9 (2018)
Abstract Background Ocular melanoma is a rare but often deadly malignancy that arises in the uvea (commonest primary site), conjunctiva or the orbit. Primary orbital melanoma (POM) is exceedingly rare, with approximately 60 cases reported to date. De
Externí odkaz:
https://doaj.org/article/ad7ad059663d44e9ac74b5a5b0894764
Publikováno v:
Frontiers in Oncology, Vol 7 (2017)
BackgroundPeriocular melanoma is a rare but often deadly malignancy that arises in the uvea (commonest origin), conjunctiva or orbit (rarest primary site). Melanoma accounts for 5–10% of metastatic/secondary orbital malignancies, but only a tiny pr
Externí odkaz:
https://doaj.org/article/a7699f0e09234301b4517f97484146e5
Autor:
Gerassimos Lascaratos, Kai-Yin Chau, Haogang Zhu, Despoina Gkotsi, Rosalind King, Ivan Gout, Deborah Kamal, Philip J. Luthert, Anthony H.V. Schapira, David F. Garway-Heath
Publikováno v:
Neurobiology of Disease, Vol 82, Iss , Pp 78-85 (2015)
Glaucomatous optic neuropathy, an important neurodegenerative condition and the commonest optic neuropathy in humans, is the leading cause of irreversible blindness worldwide. Its prevalence and incidence increase exponentially with ageing and raised
Externí odkaz:
https://doaj.org/article/602f99eca1394f7f892ca4c024b3dca2
Publikováno v:
Ophthalmic Plastic & Reconstructive Surgery. 38:e54-e57
Chronic granulomatous inflammation occurs rarely alongside pleomorphic adenomas of the major salivary glands but would not appear to have been reported with lacrimal gland adenomas. We describe the clinical features, imaging and histopathology for 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ea2c1d927a68a65e2cee9bbbd5a12e6
https://doi.org/10.1097/iop.0000000000002096
https://doi.org/10.1097/iop.0000000000002096
Autor:
Christina Kiel, Philip J. Luthert
Publikováno v:
Network and Systems Medicine
Background: Age-related macular degeneration (AMD) is the most common cause of visual impairment in the developed world. Despite some treatment options for late AMD, there is no intervention that blocks early AMD proceeding to the late and blinding f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee14cd584691ac05abb9af426ed52d8
http://europepmc.org/articles/PMC7416628
http://europepmc.org/articles/PMC7416628
Publikováno v:
Small GTPases
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Cancer is the second leading cause of death globally, and colorectal cancer (CRC) is among the five most common cancers. The small GTPase KRAS is an oncogene that is mutated in ~30% of all CRCs. Pharmacological treatments of CRC are currently unsatis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f36755851887af272789adcaf52f9df
http://europepmc.org/articles/PMC7939564
http://europepmc.org/articles/PMC7939564
Autor:
Thomas Sevrin, Lisa Strasser, Camille Ternet, Philipp Junk, Miriam Caffarini, Simona Catozzi, Giorgio Oliviero, Kieran Wynne, Christina Kiel, Philip J. Luthert
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3626222d245b6666750127be253d75b
https://doi.org/10.2139/ssrn.4133892
https://doi.org/10.2139/ssrn.4133892