Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Philip J. Forshaw"'
Publikováno v:
Journal of Neurochemistry. 79:400-406
In humans and other vertebrates, reaction of organophosphates with a neuronal membrane protein, neuropathy target esterase (NTE), initiates events which culminate in axonal degeneration. The initiation process appears to involve modification of a pro
Publikováno v:
Toxicology and Applied Pharmacology. 219:190-195
Organophosphorus compounds (OP) such as phenyl saligenin phosphate (PSP) and mipafox (MPX) which cause delayed neuropathy, inhibit neuropathy target esterase (NTE), while OPs such as paraoxon (PXN) react more readily with acetylcholinesterase. In yea
Publikováno v:
Journal of Toxicology: Clinical Toxicology. 38:95-101
Pyrethroid insecticides are widely used, but there have been relatively few reports of systemic poisoning. These reports have, however, shown that pharmacotherapy is difficult and that the duration of poisoning can be unexpectedly long. Pyrethroids a
Publikováno v:
Toxicology and applied pharmacology. 163(1)
Pyrethroids act on mammalian sodium channels, but we have previously shown that low concentrations of the type II pyrethroid deltamethrin also decrease the open channel probability (P(o)) of voltage-gated chloride channels. This effect would be expec
Publikováno v:
Neuropharmacology. 32(2)
Following the previous finding that the Type II pyrethroid, deltamethrin, increased membrane resistance in peripheral nerve and muscle in a chloride-dependent manner, the action of deltamethrin on neuronal voltage-dependent chloride channels was asse
Publikováno v:
European Journal of Pharmacology. 134:89-96
The mechanical and electrophysiological effects of two synthetic pyrethroids, cismethrin (Type I) and deltamethrin (Type II) have been studied in whole rat gastrocnemius muscle and in isolated perfused rat diaphragm. In both directly or indirectly st
Publikováno v:
Archives of Toxicology. 37:237-240
The arrhythmogenic effect of 8 microgram/kg noradrenaline given i.v. was increased in male rats pretreated 1-2 days earlier with phenobarbitone and starved from the time of the first phenobarbitone injection (80 mg/kg followed by 50 mg/kg 6 h later).
Publikováno v:
Journal of Applied Toxicology. 7:63-66
In agreement with the inhibition of dopamine-beta-hydroxylase by exposure to CS2, the extension of exposure time from 4 to 16 h increased dopamine concentrations in the hypothalmus and adrenals, and decreased noradrenaline concentration in the hypoth
Publikováno v:
Neuropharmacology. 22:907-914
Pyrethroid-induced motor symptoms, i.e. deltamethrin-induced writhing and cismethrin-induced tremor, were studied using a number of pharmacological agents, in intact conscious rats and spinal rats. In intact conscious rats, procainamide, l - and d -p
Autor:
Philip J. Forshaw
Publikováno v:
European Journal of Pharmacology. 42:371-377
Cadmium (0.125–1 mM) was found to inhibit the isometric response of the isolated rat hemidiaphragm during indirect stimulation, but not during direct stimulation. This effect of cadmium (1 mM) was completely reversed by ethyleneglycol bis-(aminoeth