Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Philip J Webber"'
Autor:
Alzbeta Trancikova, Adamantios Mamais, Philip J Webber, Klodjan Stafa, Elpida Tsika, Liliane Glauser, Andrew B West, Rina Bandopadhyay, Darren J Moore
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47784 (2012)
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are a common cause of autosomal dominant familial Parkinson's disease (PD). LRRK2 encodes a multi-domain protein containing GTPase and kinase enzymatic domains. Disease-associated mutations i
Externí odkaz:
https://doaj.org/article/86049abe11db46db90e2a405b463745d
Autor:
Klodjan Stafa, Alzbeta Trancikova, Philip J Webber, Liliane Glauser, Andrew B West, Darren J Moore
Publikováno v:
PLoS Genetics, Vol 8, Iss 2, p e1002526 (2012)
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common cause of autosomal dominant familial Parkinson's disease (PD) and also contribute to idiopathic PD. LRRK2 encodes a large multi-domain protein with GTPase and kinase activ
Externí odkaz:
https://doaj.org/article/15797c1bcf4e4a1d82f5fa020e37e892
Autor:
Kim A Caldwell, Michelle L Tucci, Jafa Armagost, Tyler W Hodges, Jue Chen, Shermeen B Memon, Jeana E Blalock, Susan M DeLeon, Robert H Findlay, Qingmin Ruan, Philip J Webber, David G Standaert, Julie B Olson, Guy A Caldwell
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7227 (2009)
Parkinson disease (PD) involves progressive neurodegeneration, including loss of dopamine (DA) neurons from the substantia nigra. Select genes associated with rare familial forms of PD function in cellular pathways, such as the ubiquitin-proteasome s
Externí odkaz:
https://doaj.org/article/58efb7b0476249b3a1bbaf2581019d84
Autor:
James A. Mobley, Sercan Sen, Matthew B. Renfrow, Archer D. Smith, Andrew B. West, Philip J. Webber
Publikováno v:
Journal of Molecular Biology. 433:167129
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddd7304606cb722ebd2583394587fb7b
https://doi.org/10.1016/j.jmb.2021.167129
https://doi.org/10.1016/j.jmb.2021.167129
Autor:
Valentina Gonzalez-Pecchi, Margaret A. Johns, Andrei A. Ivanov, Yuhong Du, Wei Zhou, Adam I. Marcus, Elizabeth A. McMillan, Qi Qi, Xiulei Mo, Cau Pham, Haian Fu, Lee Cooper, Songlin Liu, Brian Revennaugh, Michael A. White, Xiaoqian Chen, Philip J. Webber, Carlos S. Moreno, Rina Su, Fadlo R. Khuri, Lauren Rusnak, Zenggang Li, Sahar Harati, Xiang Chen
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)
As genomics advances reveal the cancer gene landscape, a daunting task is to understand how these genes contribute to dysregulated oncogenic pathways. Integration of cancer genes into networks offers opportunities to reveal protein–protein interact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d2b34d3e270fb29372dc1ff3e4e299
https://doi.org/10.1038/ncomms15350
https://doi.org/10.1038/ncomms15350
Autor:
Cau Pham, Haian Fu, Rina Su, Wei Zhou, Xiaoqian Chen, Fadlo R. Khuri, Lee Cooper, Songlin Liu, Valentina Gonzalez-Pecchi, Margaret A. Johns, Adam I. Marcus, Elizabeth A. McMillan, Brian Revennaugh, Lauren Rusnak, Yuhong Du, Xiang Chen, Zenggang Li, Sahar Harati, Carlos S. Moreno, Michael A. White, Xiulei Mo, Andrei A. Ivanov, Philip J. Webber, Qi Qi
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
As genomics advances reveal the cancer gene landscape, a daunting task is to understand how these genes contribute to dysregulated oncogenic pathways. Integration of cancer genes into networks offers opportunities to reveal protein–protein interact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::863d08e6693eead3cbce1fc9a47cbbb8
https://doi.org/10.1038/ncomms14356
https://doi.org/10.1038/ncomms14356
Autor:
David J. Maloney, Ganesha Rai, Stephen C. Kales, John R. Shanks, Philip J. Webber, Xiaodong Cheng, Matthew D. Hall, Daniel J. Jansen, Xu Liu, Ajit Jadhav, Haian Fu, Lizhen Wu, John R. Horton, Xing Zhang, Anton Simeonov, Qin Yan, Mark J. Henderson, Joshua S.K. Bell, Margaret A. Johns, Bryan T. Mott, Paula M. Vertino, Daniel J. Urban, Molly Gale
Publikováno v:
Cell chemical biology. 23(7)
The KDM5/JARID1 family of Fe(II)- and α-ketoglutarate-dependent demethylases removes methyl groups from methylated lysine 4 of histone H3. Accumulating evidence supports a role for KDM5 family members as oncogenic drivers. We compare the in vitro in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15798db65c73123559b1086da9dd88a
https://pubmed.ncbi.nlm.nih.gov/27447042
https://pubmed.ncbi.nlm.nih.gov/27447042
Autor:
David G. Standaert, Tonia Tse, Rita M. Cowell, Mark S. Moehle, Tara M. DeSilva, Nour N. Sukar, Andrew B. West, Philip J. Webber
Publikováno v:
J Neurosci
Missense mutations inleucine-rich repeat kinase 2 (LRRK2)cause late-onset Parkinson's disease (PD), and common genetic variation inLRRK2modifies susceptibility to Crohn's disease and leprosy. High levels of LRRK2 expression in peripheral monocytes an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d818c6f114b301375587f4c572006266
https://doi.org/10.1523/jneurosci.5601-11.2012
https://doi.org/10.1523/jneurosci.5601-11.2012
Autor:
Jan O. Aasly, Mathias Toft, Sarah Lincoln, Stephanie A. Cobb, Amela Felic, Carles Vilariño-Güell, Linda R. White, Andrew B. West, Kristoffer Haugarvoll, Philip J. Webber, Justus C. Dachsel, John G. Nutt, Jennifer M. Kachergus, Krisztina K. Johansen, Owen A. Ross, Christian Wider, Alexandra I. Soto-Ortolaza, Haydeh Payami, Matthew J. Farrer
Publikováno v:
Movement Disorders. 25:2156-2163
Genealogical investigation of a large Norwegian family (F04) with autosomal dominant parkinsonism has identified 18 affected family members over four generations. Genetic studies have revealed a novel pathogenic LRRK2 mutation c.4309 A>C (p.Asn1437Hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b594b45ea71e71452635c82f8f682e9
https://doi.org/10.1002/mds.23265
https://doi.org/10.1002/mds.23265
Autor:
Andrew B. West, Philip J. Webber
Publikováno v:
FEBS Journal. 276:6436-6444
The detailed characterization of the function of leucine-rich repeat kinase 2 (LRRK2) may provide insight into the molecular basis of neurodegeneration in Parkinson's disease (PD) because mutations in LRRK2 cause a phenotype with strong overlap to ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e79cbc401c2ac67462f3fcf892e2c320
https://doi.org/10.1111/j.1742-4658.2009.07342.x
https://doi.org/10.1111/j.1742-4658.2009.07342.x