Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Philip J Santangelo"'
Autor:
Lorena C S Chaves, Nichole Orr-Burks, Daryll Vanover, Varun V Mosur, Sarah R Hosking, Pramod Kumar E K, Hyeyoon Jeong, Younghun Jung, José A F Assumpção, Hannah E Peck, Sarah L Nelson, Kaitlyn N Burke, McKinzie A Garrison, Robert A Arthur, Henry Claussen, Nicholas S Heaton, Eric R Lafontaine, Robert J Hogan, Chiara Zurla, Philip J Santangelo
Publikováno v:
PLoS Pathogens, Vol 20, Iss 7, p e1012345 (2024)
The CRISPR-Cas13 system has been proposed as an alternative treatment of viral infections. However, for this approach to be adopted as an antiviral, it must be optimized until levels of efficacy rival or exceed the performance of conventional approac
Externí odkaz:
https://doaj.org/article/ff2b71e5f2c14cc889ed30f7de84cd2e
Autor:
Molly R Braun, Sarah L Noton, Emmeline L Blanchard, Afzaal Shareef, Philip J Santangelo, W Evan Johnson, Rachel Fearns
Publikováno v:
PLoS Pathogens, Vol 17, Iss 5, p e1009589 (2021)
Respiratory syncytial virus (RSV) is a major cause of respiratory disease in infants and the elderly. RSV is a non-segmented negative strand RNA virus. The viral M2-1 protein plays a key role in viral transcription, serving as an elongation factor to
Externí odkaz:
https://doaj.org/article/c6569cf61bf349b3955629b22207088c
Autor:
Emmeline L Blanchard, Molly R Braun, Aaron W Lifland, Barbara Ludeke, Sarah L Noton, Daryll Vanover, Chiara Zurla, Rachel Fearns, Philip J Santangelo
Publikováno v:
PLoS Pathogens, Vol 16, Iss 10, p e1008987 (2020)
The ribonucleocapsid complex of respiratory syncytial virus (RSV) is responsible for both viral mRNA transcription and viral replication during infection, though little is known about how this dual function is achieved. Here, we report the use of a r
Externí odkaz:
https://doaj.org/article/bd22234259b348fcbf5df7b236decc41
Autor:
Sakaorat Lertjuthaporn, Claudia Cicala, Donald Van Ryk, Matthew Liu, Jason Yolitz, Danlan Wei, Fatima Nawaz, Allison Doyle, Brooke Horowitch, Chung Park, Shan Lu, Yang Lou, Shixia Wang, Ruimin Pan, Xunqing Jiang, Francois Villinger, Siddappa N Byrareddy, Philip J Santangelo, Lynn Morris, Constantinos Kurt Wibmer, Kristin Biris, Rosemarie D Mason, Jason Gorman, Joseph Hiatt, Elena Martinelli, Mario Roederer, Dai Fujikawa, Giacomo Gorini, Genoveffa Franchini, Anush Arakelyan, Aftab A Ansari, Kovit Pattanapanyasat, Xiang-Peng Kong, Anthony S Fauci, James Arthos
Publikováno v:
PLoS Pathogens, Vol 14, Iss 8, p e1007278 (2018)
The GI tract is preferentially targeted during acute/early HIV-1 infection. Consequent damage to the gut plays a central role in HIV pathogenesis. The basis for preferential targeting of gut tissues is not well defined. Recombinant proteins and synth
Externí odkaz:
https://doaj.org/article/1d27a974a42f4d20a2e0217100ce0387
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74598 (2013)
Many studies have demonstrated an association between the cytoskeleton and mRNA, as well as the asymmetric distribution of mRNA granules within the cell in response to various signaling events. It is likely that the extensive cytoskeletal network dir
Externí odkaz:
https://doaj.org/article/2afc55f2d2fb40c682cf27c5eb4fecdf
Autor:
Yujia Liu, Yichen Ding, Eric Alonas, Wenli Zhao, Philip J Santangelo, Dayong Jin, James A Piper, Junlin Teng, Qiushi Ren, Peng Xi
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e40003 (2012)
In this report, a Ti:Sapphire oscillator was utilized to realize synchronization-free stimulated emission depletion (STED) microscopy. With pump power of 4.6 W and sample irradiance of 310 mW, we achieved super-resolution as high as 71 nm. With synch
Externí odkaz:
https://doaj.org/article/b06d9abcb57245f0b83e212c0a238897
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19727 (2011)
When cells experience environmental stresses, global translational arrest is often accompanied by the formation of stress granules (SG) and an increase in the number of p-bodies (PBs), which are thought to play a crucial role in the regulation of euk
Externí odkaz:
https://doaj.org/article/f88e231df2ab482d99ac426e2b46943b
Autor:
Jia Yao, Svetlana Atasheva, Randall Toy, Emmeline L. Blanchard, Philip J. Santangelo, Krishnendu Roy, Edward S. Mocarski, Dmitry M. Shayakhmetov
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Pathogens trigger activation of sensors of the innate immune system that initiate molecular signaling enabling appropriate host defense programs. Although recognition of pathogen-specific moieties or PAMPs by specialized receptors of the imm
Externí odkaz:
https://doaj.org/article/82c6fbda93044ded80e53e06e8ddf1db
Autor:
Syed Faaiz Enam, Sajidur Rahman Kader, Nicholas Bodkin, Johnathan G. Lyon, Mark Calhoun, Cesar Azrak, Pooja Munnilal Tiwari, Daryll Vanover, Haichen Wang, Philip J. Santangelo, Ravi Venkat Bellamkonda
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-24 (2020)
Abstract Background Appropriately modulating inflammation after traumatic brain injury (TBI) may prevent disabilities for the millions of those inflicted annually. In TBI, cellular mediators of inflammation, including macrophages and microglia, posse
Externí odkaz:
https://doaj.org/article/12bd5e2f3a6341a8ac7135fd9d2a035c
Autor:
Marine Z. C. Hatit, Curtis N. Dobrowolski, Melissa P. Lokugamage, David Loughrey, Huanzhen Ni, Chiara Zurla, Alejandro J. Da Silva Sanchez, Afsane Radmand, Sebastian G. Huayamares, Ryan Zenhausern, Kalina Paunovska, Hannah E. Peck, Jinwhan Kim, Manaka Sato, Jacob I. Feldman, Michael-Alexander Rivera, Ana Cristian, YongTae Kim, Philip J. Santangelo, James E. Dahlman
Publikováno v:
Nature Chemistry. 15:508-515
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d411f66312b8f3b3c4db27594a5df3e
https://doi.org/10.1038/s41557-023-01138-9
https://doi.org/10.1038/s41557-023-01138-9