A Hamster Model of Diet-Induced Obesity for Preclinical Evaluation of Anti-Obesity, Anti-Diabetic and Lipid Modulating Agents.

Autor: Louise S Dalbøge, Philip J Pedersen, Gitte Hansen, Katrine Fabricius, Henrik B Hansen, Jacob Jelsing, Niels Vrang

Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0135634 (2015)

Unlike rats and mice, hamsters develop hypercholesterolemia, and hypertriglyceridemia when fed a cholesterol-rich diet. Because hyperlipidemia is a hallmark of human obesity, we aimed to develop and characterize a novel diet-induced obesity (DIO) and

Externí odkaz: https://doaj.org/article/c71f9205a59d47268432a13b2c285b66

An Aldehyde Responsive, Cleavable Linker for Glucose Responsive Insulins

Autor: Lisbeth Nielsen Fink, Nina Buch-Månson, Knud J. Jensen, Narendra Kumar Mishra, Niels Vrang, Søren L. Pedersen, Karin Mannerstedt, Keld Fosgerau, Thomas Brimert, Philip J. Pedersen, Priska Le-Huu, Charlotte Madsen, Ebbe Engholm, Björn Borgström, Morten Lundh

Publikováno v: Chemistry – A European Journal. 27:3166-3176

A glucose responsive insulin (GRI) that responds to changes in blood glucose concentrations has remained an elusive goal. Here we describe the development of glucose cleavable linkers based on hydrazone and thiazolidine structures. We developed linke

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1652c966395346e739b27aaa9084a02
https://doi.org/10.1002/chem.202004878

Rat pancreatectomy combined with isoprenaline or uninephrectomy as models of diabetic cardiomyopathy or nephropathy

Autor: Thomas Secher, Philip J. Pedersen, Jacob Jelsing, Lisbeth Nielsen Fink, Louise Thisted, Andrew J. Murray, Sebastian T. Thrane, Nora E. Zois, Tanja X. Pedersen, Torben Skarsfeldt, Morten B. Thomsen, Thea T. Johansen, Ross T. Lindsay, Mette V. Østergaard, Annemarie A. Pedersen

Publikováno v: Thisted, D L A, Østergaard, M V, Pedersen, A A, Pedersen, P J, Lindsay, R T, Murray, A J, Fink, L N, Pedersen, T X, Secher, T, Johansen, T T, Thrane, S T, Skarsfeldt, T, Jelsing, J, Thomsen, M B & Zois, N E 2020, ' Rat pancreatectomy combined with isoprenaline or uninephrectomy as models of diabetic cardiomyopathy or nephropathy ', Scientific Reports, vol. 10, 16130 . https://doi.org/10.1038/s41598-020-73046-8
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Thisted, L, Ostergaard, M, Pedersen, A A, Pedersen, P J, Lindsay, R T, Murray, A J, Fink, L N, Pedersen, T X, Secher, T, Johansen, T T, Thrane, S T, Skarsfeldt, T, Jelsing, J, Thomsen, M B & Zois, N E 2020, ' Rat pancreatectomy combined with isoprenaline or uninephrectomy as models of diabetic cardiomyopathy or nephropathy ', Scientific Reports, vol. 10, no. 1, 16130 . https://doi.org/10.1038/s41598-020-73046-8

Cardiovascular and renal complications are the predominant causes of morbidity and mortality amongst patients with diabetes. Development of novel treatments have been hampered by the lack of available animal models recapitulating the human disease. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::001006a66b6924921a628f8bcb796c90
https://doi.org/10.1038/s41598-020-73046-8

Rat pancreatectomy combined with isoprenaline or uninephrectomy as models of diabetic cardiomyopathy or nephropathy

Autor: Louise, Thisted, Mette V, Østergaard, Annemarie A, Pedersen, Philip J, Pedersen, Ross T, Lindsay, Andrew J, Murray, Lisbeth N, Fink, Tanja X, Pedersen, Thomas, Secher, Thea T, Johansen, Sebastian T, Thrane, Torben, Skarsfeldt, Jacob, Jelsing, Morten B, Thomsen, Nora E, Zois

Publikováno v: Scientific reports. 10(1)

Cardiovascular and renal complications are the predominant causes of morbidity and mortality amongst patients with diabetes. Development of novel treatments have been hampered by the lack of available animal models recapitulating the human disease. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::19a14997f37a198e08186b4e440a0bbf
https://pubmed.ncbi.nlm.nih.gov/32999377

Effects of trimethoprim-sulfadiazine and detomidine on the function of equine Kv 11.1 channels in a two-electrode voltage-clamp (TEVC) oocyte model

Autor: Rikke Buhl, V. Groesfjeld Christensen, Dan A. Klaerke, Dagmar S Trachsel, Jørgen K. Kanters, Kirstine Calloe, Philip J. Pedersen, Maria de los Angeles Tejada

Publikováno v: Trachsel, D S, Tejada, M A, Groesfjeld Christensen, V, Pedersen, P J, Kanters, J K, Buhl, R, Calloe, K & Klaerke, D A 2018, ' Effects of trimethoprim–sulfadiazine and detomidine on the function of equine K v 11.1 channels in a two-electrode voltage-clamp (TEVC) oocyte model ', Journal of Veterinary Pharmacology and Therapeutics, vol. 41, no. 4, pp. 536-545 . https://doi.org/10.1111/jvp.12502

The long QT syndrome (LQTS) is a channelopathy that can lead to severe arrhythmia and sudden cardiac death. Pharmacologically induced LQTS is caused by interaction between drugs and potassium channels, especially the Kv11.1 channel. Due to such inter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac72262f9f995ef6ef3ce83022db12f1
https://doi.org/10.1111/jvp.12502