Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Philip J Kranzusch"'
Autor:
James B Eaglesham, Philip J Kranzusch
Publikováno v:
PLoS Biology, Vol 22, Iss 2, p e3002481 (2024)
Animal and bacterial cells use shared mechanisms to defend against viruses. Analyzing 3 families of immune genes, a new study in PLOS Biology illuminates this evolutionary connection and traces the emergence of antiviral signaling across domains of l
Externí odkaz:
https://doaj.org/article/beca75fcfc0c4378ba227095059145bf
Autor:
Jeremy Garb, Gil Amitai, Allen Lu, Gal Ofir, Alexander Brandis, Tevie Mehlman, Philip J Kranzusch, Rotem Sorek
Publikováno v:
PLoS ONE, Vol 19, Iss 4, p e0302251 (2024)
Sterile alpha and TIR motif-containing 1 (SARM1) is a protein involved in programmed death of injured axons. Following axon injury or a drug-induced insult, the TIR domain of SARM1 degrades the essential molecule nicotinamide adenine dinucleotide (NA
Externí odkaz:
https://doaj.org/article/b7e90677edac4007826d162c5b8c9716
Autor:
Alex G Johnson, Philip J Kranzusch
Publikováno v:
PLoS Pathogens, Vol 18, Iss 10, p e1010879 (2022)
Externí odkaz:
https://doaj.org/article/7b10e74da86647e9b702e08cdbe805ea
Publikováno v:
eLife, Vol 9 (2020)
DNA viruses in the family Poxviridae encode poxin enzymes that degrade the immune second messenger 2′3′-cGAMP to inhibit cGAS-STING immunity in mammalian cells. The closest homologs of poxin exist in the genomes of insect viruses suggesting a key
Externí odkaz:
https://doaj.org/article/4f1e60e46bfb420e9f68e40f2297fc81
Autor:
Zachary F Hallberg, Chi Ho Chan, Todd A Wright, Philip J Kranzusch, Kevin W Doxzen, James J Park, Daniel R Bond, Ming C Hammond
Publikováno v:
eLife, Vol 8 (2019)
A newfound signaling pathway employs a GGDEF enzyme with unique activity compared to the majority of homologs associated with bacterial cyclic di-GMP signaling. This system provides a rare opportunity to study how signaling proteins natively gain dis
Externí odkaz:
https://doaj.org/article/ef3b900a1173420ba4791918d80a83ac
Autor:
Azita Leavitt, Erez Yirmiya, Gil Amitai, Allen Lu, Jeremy Garb, Ehud Herbst, Benjamin R. Morehouse, Samuel J. Hobbs, Sadie P. Antine, Zhen-Yu J. Sun, Philip J. Kranzusch, Rotem Sorek
Publikováno v:
Nature. 611:326-331
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6752fba33f0abd013e5a97d55de9c67e
https://doi.org/10.1038/s41586-022-05375-9
https://doi.org/10.1038/s41586-022-05375-9
Autor:
Benjamin R. Morehouse, Matthew C. J. Yip, Alexander F. A. Keszei, Nora K. McNamara-Bordewick, Sichen Shao, Philip J. Kranzusch
Publikováno v:
Nature. 608:803-807
Stimulator of interferon genes (STING) is an antiviral signalling protein that is broadly conserved in both innate immunity in animals and phage defence in prokaryotes1–4. Activation of STING requires its assembly into an oligomeric filament struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d5db8aeda8c8d0270180f1b4fe1f6a3
https://doi.org/10.1038/s41586-022-04999-1
https://doi.org/10.1038/s41586-022-04999-1
Autor:
Desmond Richmond-Buccola, Samuel J. Hobbs, Jasmine M. Garcia, Hunter Toyoda, Jingjing Gao, Sichen Shao, Amy S. Y. Lee, Philip J. Kranzusch
Publikováno v:
bioRxiv
SUMMARYCBASS is an anti-phage defense system that protects bacteria from phage infection and is evolutionarily related to human cGAS-STING immunity. cGAS-STING signaling is initiated by viral DNA but the stage of phage replication which activates bac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d195f8e344297289a731e60abc79f44
https://doi.org/10.1101/2023.05.21.541620
https://doi.org/10.1101/2023.05.21.541620
Autor:
Erez Yirmiya, Azita Leavitt, Allen Lu, Carmel Avraham, Ilya Osterman, Jeremy Garb, Sadie P. Antine, Sarah E. Mooney, Sam J. Hobbs, Philip J. Kranzusch, Gil Amitai, Rotem Sorek
It was recently shown that bacteria employ, apart from CRISPR-Cas and restriction systems, a considerable diversity of phage resistance systems, but it is largely unknown how phages cope with this multilayered bacterial immunity. Here, we analyzed gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e80b9f023d7e4b2355907961fae8ec73
https://doi.org/10.1101/2023.05.01.538930
https://doi.org/10.1101/2023.05.01.538930
Autor:
Alex G. Johnson, Megan L. Mayer, Stefan L. Schaefer, Nora K. McNamara-Bordewick, Gerhard Hummer, Philip J. Kranzusch
Publikováno v:
bioRxiv
In response to pathogen infection, gasdermin (GSDM) proteins form membrane pores that induce a host cell death process called pyroptosis1–3. Studies of human and mouse GSDM pores reveal the functions and architectures of 24–33 protomers assemblie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d34391f06c99d839908fcbc6517307eb
https://doi.org/10.1101/2023.04.20.537723
https://doi.org/10.1101/2023.04.20.537723