Zobrazeno 1 - 10
of 210
pro vyhledávání: '"Philip J Hogg"'
Autor:
Freda Passam, Joyce Chiu, Lining Ju, Aster Pijning, Zeenat Jahan, Ronit Mor-Cohen, Adva Yeheskel, Katra Kolšek, Lena Thärichen, Camilo Aponte-Santamaría, Frauke Gräter, Philip J Hogg
Publikováno v:
eLife, Vol 7 (2018)
How proteins harness mechanical force to control function is a significant biological question. Here we describe a human cell surface receptor that couples ligand binding and force to trigger a chemical event which controls the adhesive properties of
Externí odkaz:
https://doaj.org/article/cb9308714c6048dea975537d7c8c7c92
Autor:
Keyu Lv, Shuai Chen, Xulin Xu, Joyce Chiu, Haoqing J. Wang, Yunyun Han, Xiaodan Yang, Sheryl R. Bowley, Hao Wang, Zhaoming Tang, Ning Tang, Aizhen Yang, Shuofei Yang, Jinyu Wang, Si Jin, Yi Wu, Alvin H. Schmaier, Lining A. Ju, Philip J. Hogg, Chao Fang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract The essence of difference between hemostasis and thrombosis is that the clotting reaction is a highly fine-tuned process. Vascular protein disulfide isomerase (PDI) represents a critical mechanism regulating the functions of hemostatic prote
Externí odkaz:
https://doaj.org/article/0c086c6b87a448a69a22678f0a155a5d
Autor:
Diego Butera, Philip J. Hogg
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Disulfide bonds play critical roles in determining protein structure and function. Here, the authors show that fibrinogen exists in multiple disulfide-bonded states in human blood, and that these states change during fibrin polymerization and in resp
Externí odkaz:
https://doaj.org/article/b08a8ba494e34f3294f59b0d5edbc4d5
Autor:
ZuFu Lu, Joyce Chiu, Lucinda R. Lee, Aaron Schindeler, Miriam Jackson, Yogambha Ramaswamy, Colin R. Dunstan, Philip J. Hogg, Hala Zreiqat
Publikováno v:
Stem Cells Translational Medicine, Vol 9, Iss 3, Pp 403-415 (2020)
Abstract The induced pluripotent stem cell (iPSC) is a promising cell source for tissue regeneration. However, the therapeutic value of iPSC technology is limited due to the complexity of induction protocols and potential risks of teratoma formation.
Externí odkaz:
https://doaj.org/article/ff418ee490bc4af1b5bac26799d9701b
Autor:
Ivan Ho Shon, Divesh Kumar, Chithradevi Sathiakumar, Paula Berghofer, Khang Van, Andrew Chicco, Philip J. Hogg
Publikováno v:
EJNMMI Research, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract Background 4-(N-(S-glutathionylacetyl)amino) phenylarsonous acid (GSAO) when conjugated at the γ-glutamyl residue with fluorophores and radio-isotopes is able to image dead and dying cells in vitro and in vivo by binding to intracellular 90
Externí odkaz:
https://doaj.org/article/2990945884f94eff9ed7380329beaa1e
Autor:
Zhiduan Su, James G. Burchfield, Pengyi Yang, Sean J. Humphrey, Guang Yang, Deanne Francis, Sabina Yasmin, Sung-Young Shin, Dougall M. Norris, Alison L. Kearney, Miro A. Astore, Jonathan Scavuzzo, Kelsey H. Fisher-Wellman, Qiao-Ping Wang, Benjamin L. Parker, G. Gregory Neely, Fatemeh Vafaee, Joyce Chiu, Reichelle Yeo, Philip J. Hogg, Daniel J. Fazakerley, Lan K. Nguyen, Serdar Kuyucak, David E. James
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Crosstalk between protein oxidation and other post-translational modifications remains unexplored. Here, the authors map the phosphoproteome, cysteine redox proteome and total proteome of adipocytes under acute oxidative stress and reveal crosstalk b
Externí odkaz:
https://doaj.org/article/100de65dcd654d9fbe6eaea348b3c57b
Autor:
Diego Butera, Haoqing Jerry Wang, Heng-Giap Woon, Yunduo Charles Zhao, Lining Arnold Ju, Philip J. Hogg
Publikováno v:
Blood Advances. 7:2117-2128
von Willebrand factor (VWF) is the protective carrier of procoagulant factor VIII (FVIII) in the shear forces of the circulation, prolonging its half-life and delivering it to the developing thrombus. Using force spectroscopy, VWF-FVIII complex forma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd955f3fd3cf5464004afb1aadcf7f64
https://doi.org/10.1182/bloodadvances.2022008650
https://doi.org/10.1182/bloodadvances.2022008650
Autor:
Janith A. Seneviratne, Daniel R. Carter, Rituparna Mittra, Andrew Gifford, Patrick Y. Kim, Jie‐Si Luo, Chelsea Mayoh, Alice Salib, Aldwin S. Rahmanto, Jayne Murray, Ngan C. Cheng, Zsuzsanna Nagy, Qian Wang, Ane Kleynhans, Owen Tan, Selina K. Sutton, Chengyuan Xue, Sylvia A. Chung, Yizhuo Zhang, Chengtao Sun, Li Zhang, Michelle Haber, Murray D. Norris, Jamie I. Fletcher, Tao Liu, Pierre J. Dilda, Philip J. Hogg, Belamy B. Cheung, Glenn M. Marshall
Publikováno v:
International Journal of Cancer. 152:1399-1413
The mitochondrion is a gatekeeper of apoptotic processes, and mediates drug resistance to several chemotherapy agents used to treat cancer. Neuroblastoma is a common solid cancer in young children with poor clinical outcomes following conventional ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6875b17457424eddd73450cdce82a623
https://doi.org/10.1002/ijc.34349
https://doi.org/10.1002/ijc.34349
Autor:
Divesh Kumar, John Doan, Philip J. Hogg, Chithra Sathikumar, Khang Van, Ivan Ho Shon, Jennifer Guille, Andrew Chicco, Mark Schreuder
Publikováno v:
Current Radiopharmaceuticals. 15:184-193
Background: 4-(N-(S-glutathionylacetyl)amino) phenylarsonous acid (GSAO) when conjugated with a bifunctional chelator 2,2'-(7-(1-carboxy-4-((2,5-dioxopyrrolidin-1-yl)oxy)-4- oxobutyl)-1,4,7-triazonane-1,4-diyl)diacetic acid (NODAGA) (hereafter referr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69f86ebbd3b900415d88dce55534c08d
https://doi.org/10.2174/1874471014666211122100646
https://doi.org/10.2174/1874471014666211122100646
Autor:
Scott A. Read, Kate S. O’Connor, Vijay Suppiah, Chantelle L. E. Ahlenstiel, Stephanie Obeid, Kristina M. Cook, Anthony Cunningham, Mark W. Douglas, Philip J. Hogg, David Booth, Jacob George, Golo Ahlenstiel
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Lambda interferons (IFNL) are involved in the immune response to viral infection. Here the authors show that zinc can interfere with IFNL signalling, and that in HCV patients the rs12979860 polymorphism regulates blood zinc levels and, subsequently,
Externí odkaz:
https://doaj.org/article/448cc0a156b540329808e92d9913726d