Zobrazeno 1 - 10
of 221
pro vyhledávání: '"Philip J Coates"'
Autor:
Yajing Liu, Marta Nekulova, Rudolf Nenutil, Iva Horakova, M Virginia Appleyard, Karen Murray, Jitka Holcakova, Michaela Galoczova, Philip Quinlan, Lee B Jordan, Colin A Purdie, Borivoj Vojtesek, Alastair M Thompson, Philip J Coates
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 6, Iss 1, Pp 83-93 (2020)
Abstract ΔNp63, also known as p40, regulates stemness of normal mammary gland epithelium and provides stem cell characteristics in basal and HER2‐driven murine breast cancer models. Whilst ΔNp63/p40 is a characteristic feature of normal basal cel
Externí odkaz:
https://doaj.org/article/3cd8cd98aa5044f882f47e3842a4e081
Autor:
Xiaolian Gu, Linda Boldrup, Philip J Coates, Robin Fahraeus, Lixiao Wang, Torben Wilms, Lena Norberg‐Spaak, Nicola Sgaramella, Karin Nylander
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 5, Iss 4, Pp 240-247 (2019)
Abstract Immune cells and cytolytic activity within the tumor microenvironment are being intensively studied. Through transcriptome profiling, immune cell enumeration using the xCell tool and cytolytic activity quantification according to granzyme A
Externí odkaz:
https://doaj.org/article/665c6e99d71e40f0964646992cb9be99
Autor:
Torben Wilms, Gulfaraz Khan, Philip J Coates, Nicola Sgaramella, Robin Fåhraeus, Asma Hassani, Pretty S Philip, Lena Norberg Spaak, Luigi Califano, Giuseppe Colella, Katarina Olofsson, Christos Loizou, Renato Franco, Karin Nylander
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184201 (2017)
Squamous cell carcinoma of the head and neck (SCCHN) comprises a large group of cancers in the oral cavity and nasopharyngeal area that typically arise in older males in association with alcohol/tobacco usage. Within the oral cavity, the mobile tongu
Externí odkaz:
https://doaj.org/article/6eb89198070f4046a934a58d19ba5366
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract TGFβ has roles in inflammation, wound healing, epithelial to mesenchymal transition (EMT), and cancer stem cell states, and acts as a tumor suppressor gene for squamous cell carcinoma (SCC). SCCs are also characterized by high levels of ΔN
Externí odkaz:
https://doaj.org/article/0197c56705854f87a3cdf3de7cd7f3b9
Autor:
Janice E Drew, Andrew J Farquharson, Claus Dieter Mayer, Hollie F Vase, Philip J Coates, Robert J Steele, Francis A Carey
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e113071 (2014)
Cancers exhibit abnormal molecular signatures associated with disease initiation and progression. Molecular signatures could improve cancer screening, detection, drug development and selection of appropriate drug therapies for individual patients. Ty
Externí odkaz:
https://doaj.org/article/1f28f952dd364e30a62c62c89068f786
Publikováno v:
Pathology and Oncology Research, Vol 28 (2022)
Signal transducer and activator of transcription 3 (Stat3) is responsible for many aspects of normal development and contributes to the development and progression of cancer through regulating epithelial cell identity and cancer stem cells. In breast
Externí odkaz:
https://doaj.org/article/8d7cd23200ef4d5293bbb154d32f90cb
Autor:
Xiaolian Gu, Lixiao Wang, Philip J Coates, Sivakumar Vadivel Gnanasundram, Nicola Sgaramella, Jonas Sörlin, Baris Erdogan, Mustafa Magan, Karin Nylander
Publikováno v:
The Journal of Pathology. 259:93-102
Oral cancer is a paradigm of Slaughter's concept of field cancerization, where tumors are thought to originate within an area of cells containing genetic alterations that predispose to cancer development. The field size is unclear but may represent a
Autor:
Torben Wilms, Linda Boldrup, Xiaolian Gu, Philip J. Coates, Nicola Sgaramella, Karin Nylander
Publikováno v:
Biomedicines, Vol 9, Iss 5, p 506 (2021)
Circulating lipoproteins as risk factors or prognostic indicators for various cancers have been investigated previously; however, no clear consensus has been reached. In this study, we aimed at evaluating the impact of serum lipoproteins on the progn
Externí odkaz:
https://doaj.org/article/70753600330b4d558289600343c447ad
Supplementary Table 1 from Indirect Macrophage Responses to Ionizing Radiation: Implications for Genotype-Dependent Bystander Signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d475ca46db25a9312f8520e8bf2e73a
https://doi.org/10.1158/0008-5472.22375238.v1
https://doi.org/10.1158/0008-5472.22375238.v1
Autor:
Alastair M. Thompson, John A. Dewar, Eric G. Wright, Alastair J. Munro, Colin A. Purdie, Lee B. Jordan, Dougal J.A. Adamson, Douglas C. Brown, June Gardner, Caroline Ackland, Karen Murray, C.L. Appleyard, M. Virginia, Philip J. Coates
Supplementary Figure 1 from Differential Contextual Responses of Normal Human Breast Epithelium to Ionizing Radiation in a Mouse Xenograft Model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2101f2040e61805424933120e6ff85f2
https://doi.org/10.1158/0008-5472.22386350
https://doi.org/10.1158/0008-5472.22386350