Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Philip J, Troilo"'
Autor:
Stephen Pacchione, Amy B. Barnum, Jayanthi J. Wolf, Philip J. Troilo, Thomas G. Griffiths, Cindy Pauley, B J Ledwith, Laural B. Harper, Zhibin Wang, José A. Lebrón
Publikováno v:
Gene Therapy. 29:322-332
While generally referred to as "non-integrating" vectors, adenovirus vectors have the potential to integrate into host DNA via random, illegitimate (nonhomologous) recombination. The present study provides a quantitative assessment of the potential i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34e6e97f82b874b015ce241a18e64ef3
https://doi.org/10.1038/s41434-021-00278-2
https://doi.org/10.1038/s41434-021-00278-2
Autor:
Zhibin, Wang, Philip J, Troilo, Thomas G, Griffiths, Laural B, Harper, Amy B, Barnum, Stephen J, Pacchione, Cindy J, Pauley, Jose A, Lebron, Jayanthi, Wolf, Brian J, Ledwith
Publikováno v:
Gene therapy. 29(6)
While generally referred to as "non-integrating" vectors, adenovirus vectors have the potential to integrate into host DNA via random, illegitimate (nonhomologous) recombination. The present study provides a quantitative assessment of the potential i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e5ccc71c22ad494506ad0ada50fa9db1
https://pubmed.ncbi.nlm.nih.gov/34404916
https://pubmed.ncbi.nlm.nih.gov/34404916
Autor:
Zhutian Niu, Thomas G. Griffiths, Krista L. Striano, Zhibin Wang, Stephen Pacchione, José A. Lebrón, Jayanthi J. Wolf, Philip J. Troilo
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 63:174-179
Introduction Various animal models are routinely used to evaluate the efficacy and toxicity of small interfering RNA (siRNA) therapeutics. Given that the most common measure of efficacy with siRNA therapeutics is mRNA knockdown, the development of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25382661c13a005445e1f5f9b8ec8147
https://doi.org/10.1016/j.vascn.2010.09.006
https://doi.org/10.1016/j.vascn.2010.09.006
Autor:
Izhack Hemo, Eithan Galun, Zhutian Niu, Gideon Zamir, Orit Papo, Ofer Nussbaum, Dana F. Roden, Philip J. Troilo, Zakharia Manevitch, Michal Gropp, Evelyne Zeira, Rimma Barsuk, Nili Daudi, Stephen Pacchione, Alexandra Manevitch, Thomas G. Griffiths, Aaron Lewis, Hagit Yotvat, Menahem Harati, Eli Kedar
Publikováno v:
The FASEB Journal. 21:3522-3533
A femtosecond laser beam gene transduction (SG-LBGT) system is described as a novel and efficient method of intradermal (i.d.) nonviral gene delivery in mice by permeabilizing cells utilizing femtosecond laser pulses. Using this approach, significant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17643100f400b9ab417529bb188d435e
https://doi.org/10.1096/fj.06-7528com
https://doi.org/10.1096/fj.06-7528com
Autor:
Cindy J. Pauley, Warren W. Nichols, Carolann M. Beare, Amy B. Barnum, Sujata Manam, Walter J. Bagdon, Philip J. Troilo, Brian J. Ledwith, Laural B. Harper, Thomas G. Griffiths
Publikováno v:
Intervirology. 43:258-272
The primary safety concern for DNA vaccines is their potential to integrate into the host cell genome. We describe an integration assay based on purification of high-molecular-weight genomic DNA away from free plasmid using gel electrophoresis, such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e69a9a146e0bf5dbd4a9662a6afe7cfe
https://doi.org/10.1159/000053993
https://doi.org/10.1159/000053993
Autor:
Zhibin Wang, Warren W. Nichols, Laural B. Harper, Walter J. Bagdon, Thomas G. Griffiths, B J Ledwith, Lyudmila Denisova, Philip J. Troilo, Zhutian Niu, Thy T. Follmer, Amy B. Barnum, Sujata Manam, Carolann M. Beare, Stephen Pacchione, Cindy J. Pauley
Publikováno v:
Intervirology. 43:273-281
A variety of factors could affect the frequency of integration of plasmid DNA vaccines into host cellular DNA, including DNA sequences within the plasmid, the expressed gene product (antigen), the formulation, delivery method, route of administration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52d4d55e7fcb83c9a68c4ac8db5a1c6a
https://doi.org/10.1159/000053994
https://doi.org/10.1159/000053994
Publikováno v:
Mutation Research Letters. 283:237-242
Chromosomal aberration (CA) and sister-chromatid exchange (SCE) frequencies have been assessed in 9 patients with von Recklinghausen's neurofibromatosis (NF1) and 8 apparently healthy controls. In separate experiments over a 5-year period, blood lymp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e07c890b14fd5665a6fed4552920cab7
https://doi.org/10.1016/0165-7992(92)90054-l
https://doi.org/10.1016/0165-7992(92)90054-l
Autor:
James H. Clair, Matthew J. van Zwieten, Dennis J. Joslyn, Karen R. Leander, Sujata Manam, Philip J. Troilo, Warren W. Nichols, Brian J. Ledwith, Keith A. Soper, Srinivasa Prahalada
Publikováno v:
Carcinogenesis. 16(5)
We investigated whether somatic rearrangements in minisatellite DNA are more frequent in chemically induced mouse liver tumors than they are in spontaneous tumors. CD-1 mouse liver tumors were induced by either a single dose or 15 consecutive daily d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81d873d9b028d151da1abc015a5e7d39
https://pubmed.ncbi.nlm.nih.gov/7767981
https://pubmed.ncbi.nlm.nih.gov/7767981
Autor:
Amy B. Barnum, Sergey N. Kochetkov, N. Tordo, Gösta Winberg, H.P. Hefti, Natalia N. Petrakova, Minchao Chen, Zhibin Wang, Sujata Manam, Maria G. Isaguliants, J. Schultz, Jeffrey B. Ulmer, Dan H. Barouch, B. Hejdeman, Jeong-Im Sin, Stephen J. Pacchione, Fengfeng Xu, Mei Hong, P. Perrin, Karin Mölling, R. Z. Gizatullin, Thomas G. Griffiths, Carolann M. Beare, Katja Pokrovskaya, Mark J. Selby, Anne Kjerrström, Cindy J. Pauley, E. Operschall, Laural B. Harper, Zhutian Niu, Bartek Zuber, Warren W. Nichols, D. A. Kostyuk, Mary Schaefer, Gillis R. Otten, B. Wahren, Tong Wu, Cheryl Goldbeck, T. Schuh, David B. Weiner, Britta Wahren, Y. Jacob, Thy T. Follmer, Klaus Cichutek, K. Mölling, Walter J. Bagdon, A.L. Hultström, Brian J. Ledwith, Michael J. McCluskie, Jorma Hinkula, Lyudmila Denisova, G. Bratt, Günter Dollenmaier, Barbara Doe, Lacrimiora Comanita, Philip J. Troilo, Jan Schultz, J. Pavlovic, Norman L. Letvin, Risini D. Weeratna, Kenneth Lundstrom, M. Nawrath, E. Carbone, Heather L. Davis, A.C. Leandersson
Publikováno v:
Intervirology. 43:343-344
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::faf95d40fcf01e52298ae711f27ec3e2
https://doi.org/10.1159/000054005
https://doi.org/10.1159/000054005