Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Philip J, Smaldino"'
Autor:
Joseph M. Gumina, Adam E. Richardson, Mahmudul Hasan Shojiv, Antonio E. Chambers, Siara N. Sandwith, Michael A. Reisinger, Taylor J. Karns, Tyler L. Osborne, Hasna N. Alashi, Quinn T. Anderson, Meredith E. Sharlow, Dylan C. Seiler, Evan M. Rogers, Anna R. Bartosik, Melissa A. Smaldino, James P. Vaughn, Yuh-Hwa Wang, Philip J. Smaldino, Robert A. Haney
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1753 (2024)
G-quadruplexes (G4s) are secondary DNA and RNA structures stabilized by positive cations in a central channel formed by stacked tetrads of Hoogsteen base-paired guanines. G4s form from G-rich sequences across the genome, whose biased distribution in
Externí odkaz:
https://doaj.org/article/5ce20ac284214326b4661fa852e80435
Autor:
Adam. E. Richardson, Zachary. A. Zentz, Antonio E. Chambers, Siara N. Sandwith, Michael A. Reisinger, Destinee W. Saunders, Joshua D. Tompkins, Arthur D. Riggs, Eric D. Routh, Eric M. Rubenstein, Melissa A. Smaldino, James P. Vaughn, Robert A. Haney, Philip J. Smaldino
Publikováno v:
ACS Omega, Vol 5, Iss 38, Pp 24916-24926 (2020)
Externí odkaz:
https://doaj.org/article/3e864a15bddf436ab2a010b8f3d9be8d
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 3, Pp 573-578 (2016)
Isolation of endogenous proteins from Saccharomyces cerevisiae has been facilitated by inserting encoding polypeptide affinity tags at the C-termini of chromosomal open reading frames (ORFs) using homologous recombination of DNA fragments. Tagged pro
Externí odkaz:
https://doaj.org/article/19556289a8fb4969aa02ccfc30b69b2a
Autor:
Samantha M. Turk, Christopher J. Indovina, Danielle L. Overton, Avery M. Runnebohm, Cade J. Orchard, Ellen M. Doss, Kyle A. Richards, Courtney Broshar Irelan, Mahmoud M. Daraghmi, Connor G. Bailey, Jacob M. Miller, Julia M. Niekamp, Samantha K. Gosser, Mary E. Tragesser-Tiña, Kieran P. Claypool, Sarah M. Engle, Bryce W. Buchanan, Kelsey A. Woodruff, James B. Olesen, Philip J. Smaldino, Eric M. Rubenstein
The relationship between lipid homeostasis and protein homeostasis (proteostasis) is complex and remains incompletely understood. We conducted a screen for genes required for efficient degradation ofDeg1-Sec62, a model aberrant translocon-associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe8ef0bf08f1938422e157064af703a0
https://doi.org/10.1101/2022.12.09.519544
https://doi.org/10.1101/2022.12.09.519544
Publikováno v:
Journal of Teaching and Learning, Vol 11, Iss 2 (2018)
It would be safe to say that nearly every student enrolled in college knows someone who has been impacted by cancer. After all, cancer killed nearly 8.2 million people worldwide in 2012 (World Cancer Report, 2014). Using this fact as the impetus for
Externí odkaz:
https://doaj.org/article/080c9f86a5ae4c2093afa767bb73f938
Autor:
Melissa A. Smaldino, Adam E. Richardson, Siara N. Sandwith, Emily S. Schmidt, Philip J. Smaldino, Antonio E. Chambers, Destinee W. Saunders, Michael A. Reisinger
Publikováno v:
The American Biology Teacher. 82:624-627
We present a novel adaptation of a typical science laboratory protocol, which we have termed multi-view protocols (MVPs). The purpose of MVPs is to answer and link three common questions asked by students when first learning a laboratory technique: (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c373873157c9478798fa7bf71a5dfeb5
https://doi.org/10.1525/abt.2020.82.9.624
https://doi.org/10.1525/abt.2020.82.9.624
Autor:
James B. Olesen, Avery M. Runnebohm, Adam E. Richardson, Philip J. Smaldino, Samantha M. Turk, Melissa D Evans, Eric M. Rubenstein
Publikováno v:
Fine Focus
Ubr1 is a conserved ubiquitin ligase involved in the degradation of aberrant proteins in eukaryotic cells. The human enzyme is found mutated in patients with Johanson-Blizzard syndrome. We hypothesized that Ubr1 is necessary for optimal cellular fitn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d008930e3bc8f627eaa7c94eeaf3fe7
https://doi.org/10.33043/ff.6.1.76-83
https://doi.org/10.33043/ff.6.1.76-83
Autor:
Ellen M, Doss, Mary E, Tragesser-Tiña, Yanru, Huang, Philip J, Smaldino, Jason D, True, Ashley L, Kalinski, Eric M, Rubenstein
Publikováno v:
microPublication biology. 2022
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8d5ad40abedbfedc74c9f77a484d4893
https://pubmed.ncbi.nlm.nih.gov/35622489
https://pubmed.ncbi.nlm.nih.gov/35622489
Autor:
Philip J Smaldino, Eric D Routh, Jung H Kim, Banabihari Giri, Steven D Creacy, Roy R Hantgan, Steven A Akman, James P Vaughn
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132668 (2015)
Ends of human chromosomes consist of the six nucleotide repeat d[pTTAGGG]n known as telomeric DNA, which protects chromosomes. We have previously shown that the DHX36 gene product, G4 Resolvase 1 (G4R1), binds parallel G-quadruplex (G4) DNA with an u
Externí odkaz:
https://doaj.org/article/a197ea1e19fe44bc874be96b8aff12ca
Autor:
Kelsey A, Woodruff, Kyle A, Richards, Melissa D, Evans, Abigail R, Scott, Brian M, Voas, Courtney Broshar, Irelan, James B, Olesen, Philip J, Smaldino, Eric M, Rubenstein
Publikováno v:
microPublication Biology
The heterotrimeric Asi ubiquitin ligase (encoded by ASI1, ASI2, and ASI3) mediates protein degradation in the inner nuclear membrane in Saccharomyces cerevisiae. Asi1p and Asi3p possess catalytic domains, while Asi2p functions as an adaptor for a sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9536e4658b32b8501e50aefe2384e495
https://pubmed.ncbi.nlm.nih.gov/34095778
https://pubmed.ncbi.nlm.nih.gov/34095778