Výsledky vyhledávání - "Philip J, Sherratt"

A Chemoproteomics Approach to Determine the Mechanism of Testicular Toxicity for the Bruton’s Tyrosine Kinase Inhibitor CC-292

Autor: Matt Labenski, Alan F Corin, Aravind Prasad Medikonda, Philip J. Sherratt, Lukas Voortman

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 379:166-174

During drug development, potential safety issues can occur at any time. Understanding the cause of a toxicity can help with deciding on how to advance the drug development program. Chemoproteomics provides a way to help understand the cause of a toxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba0195acff67bf19e6b680b01ab1b6ca
https://doi.org/10.1124/jpet.121.000614

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Next‐Generation DILI Biomarkers: Prioritization of Biomarkers for Qualification and Best Practices for Biospecimen Collection in Drug Development

Autor: Lila Ramaiah, Douglas A. Keller, Michael Merz, David Brott, Silvia Lentini, Lucas Westcott‐Baker, Paul B. Watkins, Shashi K. Ramaiah, David L. Bourdet, Ann Marie Stanley, Rachel J. Church, Sharin E. Roth, Ajit Dash, Philip J. Sherratt, Mark I. Avigan, John Marcinak

Publikováno v: Clinical Pharmacology and Therapeutics

The diagnosis and management of drug-induced liver injury (DILI) remains a challenge in clinical trials in drug development. The qualification of emerging biomarkers capable of predicting DILI soon after the initiation of treatment, differentiating D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b75b21112abd059a7095cf1e95b7259e
http://europepmc.org/articles/PMC7006882

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Erratum to 'Prediction of non-genotoxic carcinogenesis in rats using changes in gene expression following acute dosing'

Autor: Paul, Nioi, Ingrid D R, Pardo, Philip J, Sherratt, Mark R, Fielden, Jeremy, Gollub, Alex, Nie, Ronald D, Snyder

Publikováno v: Chemico-Biological Interactions. 176:252-260

Carcinogenicity of chemicals can currently only be evaluated in 2-year rodent bioassays. Therefore, the development of early biomarkers for carcinogenesis would result in substantial savings in time and expense. The current study investigates whether

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f671fe5f83f41b08e40cefd4152aa261
https://doi.org/10.1016/j.cbi.2008.09.005

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The Carboxy-Terminal Neh3 Domain of Nrf2 Is Required for Transcriptional Activation

Autor: Paul Nioi, Cecil B. Pickett, Philip J. Sherratt, Truyen Nguyen

Publikováno v: Molecular and Cellular Biology. 25:10895-10906

Nrf2 is a transcription factor critical for the maintenance of cellular redox homeostasis. We have previously found that Nrf2 is a labile protein, and its activation in cells under stress involves mechanisms leading to its stabilization. As a modular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef222cadf6cdda2f1079520730138e27
https://doi.org/10.1128/mcb.25.24.10895-10906.2005

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Nrf2 Controls Constitutive and Inducible Expression of ARE-driven Genes through a Dynamic Pathway Involving Nucleocytoplasmic Shuttling by Keap1

Autor: Philip J. Sherratt, Chung S. Yang, Paul Nioi, Truyen Nguyen, Cecil B. Pickett

Publikováno v: Journal of Biological Chemistry. 280:32485-32492

Nrf2 regulates the expression of genes encoding antioxidant proteins involved in cellular redox homeostasis. Previous studies have suggested that activation of Nrf2 is mediated by mechanisms promoting its dissociation from Keap1, a cytosolic represso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7635df680dcbfd82b6546538ed602028
https://doi.org/10.1074/jbc.m503074200

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Regulatory Mechanisms Controlling Gene Expression Mediated by the Antioxidant Response Element

Autor: Truyen Nguyen, Cecil B. Pickett, Philip J. Sherratt

Publikováno v: Annual Review of Pharmacology and Toxicology. 43:233-260

The expression of genes encoding antioxidative and Phase II detoxification enzymes is induced in cells exposed to electrophilic compounds and phenolic antioxidants. Induction of these enzymes is regulated at the transcriptional level and is mediated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42c9b5de0a9e37bc7c775470550c0442
https://doi.org/10.1146/annurev.pharmtox.43.100901.140229

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Increased Protein Stability as a Mechanism That Enhances Nrf2-mediated Transcriptional Activation of the Antioxidant Response Element

Autor: H.-C. Huang, Chung S. Yang, Truyen Nguyen, Cecil B. Pickett, Philip J. Sherratt

Publikováno v: Journal of Biological Chemistry. 278:4536-4541

Nrf2 (NF-E2-related factor 2) is a central transcription factor involved in the transcriptional activation of many genes encoding phase II drug-metabolizing enzymes via the antioxidant response element. Nrf2 has previously been found to undergo nucle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a21298ce194ee0f2859febb4fd754303
https://doi.org/10.1074/jbc.m207293200

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