Chronic peptide-based GIP receptor inhibition exhibits modest glucose metabolic changes in mice when administered either alone or combined with GLP-1 agonism.

Autor: Jason A West, Anastasia Tsakmaki, Soumitra S Ghosh, David G Parkes, Rikke V Grønlund, Philip J Pedersen, David Maggs, Harith Rajagopalan, Gavin A Bewick

Publikováno v: PLoS ONE, Vol 16, Iss 3, p e0249239 (2021)

Combinatorial gut hormone therapy is one of the more promising strategies for identifying improved treatments for metabolic disease. Many approaches combine the established benefits of glucagon-like peptide-1 (GLP-1) agonism with one or more addition

Externí odkaz: https://doaj.org/article/0d79c9bba3884a64acb17d2b7e8c1e7b

Evaluation of electrocardiographic repolarization parameters after administration of trimethoprim-sulfadiazine, detomidine, or their combination in horses

Autor: Christine Scott Lunddahl, Philip J. Pedersen, Rikke Buhl, Dagmar S Trachsel, Elin J Rgensen, Dan A. Klaerke, Kirstine Calloe, J Rgen K Kanters

Publikováno v: American Journal of Veterinary Research. 82:207-217

OBJECTIVE To determine whether administration of trimethoprim-sulfadiazine (TMS), detomidine (DET), or TMS plus DET would be associated with changes in ECG repolarization parameters in horses. ANIMALS 9 healthy adult horses. PROCEDURES Each horse rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db41c663d5934d1f02741603d298794d
https://doi.org/10.2460/ajvr.82.3.207

A Hamster Model of Diet-Induced Obesity for Preclinical Evaluation of Anti-Obesity, Anti-Diabetic and Lipid Modulating Agents.

Autor: Louise S Dalbøge, Philip J Pedersen, Gitte Hansen, Katrine Fabricius, Henrik B Hansen, Jacob Jelsing, Niels Vrang

Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0135634 (2015)

Unlike rats and mice, hamsters develop hypercholesterolemia, and hypertriglyceridemia when fed a cholesterol-rich diet. Because hyperlipidemia is a hallmark of human obesity, we aimed to develop and characterize a novel diet-induced obesity (DIO) and

Externí odkaz: https://doaj.org/article/c71f9205a59d47268432a13b2c285b66

Rat pancreatectomy combined with isoprenaline or uninephrectomy as models of diabetic cardiomyopathy or nephropathy

Autor: Thomas Secher, Philip J. Pedersen, Jacob Jelsing, Lisbeth Nielsen Fink, Louise Thisted, Andrew J. Murray, Sebastian T. Thrane, Nora E. Zois, Tanja X. Pedersen, Torben Skarsfeldt, Morten B. Thomsen, Thea T. Johansen, Ross T. Lindsay, Mette V. Østergaard, Annemarie A. Pedersen

Publikováno v: Thisted, D L A, Østergaard, M V, Pedersen, A A, Pedersen, P J, Lindsay, R T, Murray, A J, Fink, L N, Pedersen, T X, Secher, T, Johansen, T T, Thrane, S T, Skarsfeldt, T, Jelsing, J, Thomsen, M B & Zois, N E 2020, ' Rat pancreatectomy combined with isoprenaline or uninephrectomy as models of diabetic cardiomyopathy or nephropathy ', Scientific Reports, vol. 10, 16130 . https://doi.org/10.1038/s41598-020-73046-8
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Thisted, L, Ostergaard, M, Pedersen, A A, Pedersen, P J, Lindsay, R T, Murray, A J, Fink, L N, Pedersen, T X, Secher, T, Johansen, T T, Thrane, S T, Skarsfeldt, T, Jelsing, J, Thomsen, M B & Zois, N E 2020, ' Rat pancreatectomy combined with isoprenaline or uninephrectomy as models of diabetic cardiomyopathy or nephropathy ', Scientific Reports, vol. 10, no. 1, 16130 . https://doi.org/10.1038/s41598-020-73046-8

Cardiovascular and renal complications are the predominant causes of morbidity and mortality amongst patients with diabetes. Development of novel treatments have been hampered by the lack of available animal models recapitulating the human disease. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::001006a66b6924921a628f8bcb796c90
https://doi.org/10.1038/s41598-020-73046-8

Rat pancreatectomy combined with isoprenaline or uninephrectomy as models of diabetic cardiomyopathy or nephropathy

Autor: Louise, Thisted, Mette V, Østergaard, Annemarie A, Pedersen, Philip J, Pedersen, Ross T, Lindsay, Andrew J, Murray, Lisbeth N, Fink, Tanja X, Pedersen, Thomas, Secher, Thea T, Johansen, Sebastian T, Thrane, Torben, Skarsfeldt, Jacob, Jelsing, Morten B, Thomsen, Nora E, Zois

Publikováno v: Scientific reports. 10(1)

Cardiovascular and renal complications are the predominant causes of morbidity and mortality amongst patients with diabetes. Development of novel treatments have been hampered by the lack of available animal models recapitulating the human disease. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::19a14997f37a198e08186b4e440a0bbf
https://pubmed.ncbi.nlm.nih.gov/32999377