Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Philip J, Day"'
Publikováno v:
Pharmaceutics, Vol 16, Iss 7, p 928 (2024)
The clinical management of malignant tumours is challenging, often leading to severe adverse effects and death. Drug resistance (DR) antagonises the effectiveness of treatments, and increasing drug dosage can worsen the therapeutic index (TI). Curren
Externí odkaz:
https://doaj.org/article/fe7c9fbb04af41b2abdb06f234e1e7c3
Autor:
Joanna E. Parkes, Anastasia Thoma, Adam P. Lightfoot, Philip J. Day, Hector Chinoy, Janine A. Lamb
Publikováno v:
BMC Rheumatology, Vol 4, Iss 1, Pp 1-9 (2020)
Abstract Background The idiopathic inflammatory myopathies (IIMs) are heterogeneous autoimmune conditions of skeletal muscle inflammation and weakness. MicroRNAs (miRNAs) are short, non-coding RNA which regulate gene expression of target mRNAs. The a
Externí odkaz:
https://doaj.org/article/7cb5bf7ea5c144f1989403fe92887ded
Publikováno v:
BMC Microbiology, Vol 19, Iss 1, Pp 1-16 (2019)
Abstract Background It is widely believed that most xenobiotics cross biomembranes by diffusing through the phospholipid bilayer, and that the use of protein transporters is an occasional adjunct. According to an alternative view, phospholipid bilaye
Externí odkaz:
https://doaj.org/article/92b40ba41ef84a2284ff87153d34d5dc
Publikováno v:
PeerJ Computer Science, Vol 3, p e120 (2017)
CodonGenie, freely available from http://codon.synbiochem.co.uk, is a simple web application for designing ambiguous codons to support protein mutagenesis applications. Ambiguous codons are derived from specific heterogeneous nucleotide mixtures, whi
Externí odkaz:
https://doaj.org/article/3f96b511f2b24658acc379ae710a1ca8
Autor:
Anne Cleasby, Jeff Yon, Philip J Day, Caroline Richardson, Ian J Tickle, Pamela A Williams, James F Callahan, Robin Carr, Nestor Concha, Jeffrey K Kerns, Hongwei Qi, Thomas Sweitzer, Paris Ward, Thomas G Davies
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98896 (2014)
The protein Keap1 is central to the regulation of the Nrf2-mediated cytoprotective response, and is increasingly recognized as an important target for therapeutic intervention in a range of diseases involving excessive oxidative stress and inflammati
Externí odkaz:
https://doaj.org/article/e0c4767540824921bd96b680725f39ab
Autor:
Ivayla Roberts, Steve O'Hagan, Philip J. Day, Marina Wright Muelas, Farah Mughal, Douglas B. Kell
Publikováno v:
Wright Muelas, M, Roberts, I, Mughal, F, O’Hagan, S, Day, P J & Kell, D B 2020, ' An untargeted metabolomics strategy to measure differences in metabolite uptake and excretion by mammalian cell lines ', Metabolomics, vol. 16, no. 10, 107 . https://doi.org/10.1007/s11306-020-01725-8
METABOLOMICS
Metabolomics
METABOLOMICS
Metabolomics
Introduction It is widely but erroneously believed that drugs get into cells by passing through the phospholipid bilayer portion of the plasma and other membranes. Much evidence shows, however, that this is not the case, and that drugs cross biomembr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3626df71aff4433dbe754c5f17304dd4
https://doi.org/10.1101/2020.06.02.129239
https://doi.org/10.1101/2020.06.02.129239
Autor:
Yann Dudit, Zehong Wan, Don O. Somers, Yingxia Sang, Vipulkumar Kantibhai Patel, Pascal Grondin, Joseph E. Coyle, Veronique Beneton, Rachel McMenamin, Lee William Page, Philip J. Day, Alison Jo-Anne Woolford, Lionel Trottet, Valerio Berdini, Florent Potvain, Sharna J. Rich, Christopher William Murray, Pascal Huet, Lydia Y. W. Lee, Xiaomin Zhang, Eric S. Manas
Publikováno v:
Journal of Medicinal Chemistry. 59:10738-10749
Lp-PLA2 has been explored as a target for a number of inflammation associated diseases, including cardiovascular disease and dementia. This article describes the discovery of a new fragment derived chemotype that interacts with the active site of Lp-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e0ae2687867d1f42424c9a09ec700b8
https://doi.org/10.1021/acs.jmedchem.6b01427
https://doi.org/10.1021/acs.jmedchem.6b01427
Autor:
Kirsten V. Smith, Joseph E. Pero, Ralph A. Rivero, Donald O. Somers, Vipulkumar Kantibhai Patel, Agnes C. L. Martin, Rachel McMenamin, Sridhar Aravapalli, Finn P. Holding, Eric S. Manas, Lionel Trottet, Alison Jo-Anne Woolford, Neipp Christopher E, Lydia Y. W. Lee, Ranganadh Velagaleti, Sharna J. Rich, Ren Xie, Peng Li, Glyn Williams, Andrew M. Dodson, Brent W. Mccleland, Lee William Page, Joseph P. Marino, Pascal Grondin, Florent Potvain, Joseph E. Coyle, Christopher William Murray, Philip J. Day, Valerio Berdini
Publikováno v:
Journal of Medicinal Chemistry. 59:5356-5367
Elevated levels of human lipoprotein-associated phospholipase A2 (Lp-PLA2) are associated with cardiovascular disease and dementia. A fragment screen was conducted against Lp-PLA2 in order to identify novel inhibitors. Multiple fragment hits were obs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d7919286100bbcfc9e76bca6023c7c4
https://doi.org/10.1021/acs.jmedchem.6b00212
https://doi.org/10.1021/acs.jmedchem.6b00212
Autor:
Christopher Charles Frederick Hamlett, Shimamura Tadashi, Steve Hiscock, Keisha Hearn, Juan Castro, T.G. Davies, Philip J. Day, James Edward Harvey Day, Yasuo Kodama, Kenichi Matsuo, Nicola G. Wallis, Amanda J. Price, Rhian S. Holvey, Valerio Berdini, Nick Palmer, Christopher N. Johnson, Gianni Chessari, Jeffrey D. St. Denis, Yoko Nakatsuru, Glyn Williams, Satoshi Fukaya, Satoru Ito
Publikováno v:
Cancer Research. 80:1039-1039
The ubiquitously expressed protein tyrosine phosphatase SHP2 is required for signalling downstream of receptor tyrosine kinases (RTKs) and plays a role in regulating many cellular processes. Recent advances have shown that genetic knockdown and pharm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c05e51817378141de98efd04bfce5ba9
https://doi.org/10.1158/1538-7445.am2020-1039
https://doi.org/10.1158/1538-7445.am2020-1039
Autor:
Joe Coyle, Lee William Page, Dave Clapham, Karen Affleck, Paul N. Mortenson, Jonathan P. Hutchinson, Ashley Paul Hancock, Melanie Leveridge, Joelle Le, Heather Hobbs, David Norton, Rachel McMenamin, Simon Teague, Emma Sherriff, Linda J. Russell, Sorif Uddin, Caroline Richardson, Anne Cleasby, Simon Teanby Hodgson, Philip J. Day, Martyn Frederickson, Gordon Saxty
Publikováno v:
Med. Chem. Commun.. 5:134-141
Using X-ray crystallographic screening, fragments 4 and 6 were identified as inhibitors of hematopoietic prostaglandin D2 synthase (H-PGDS). Both fragments induced a small protein movement in the X-ray crystal structure relative to the apo structure,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f3850d001e5b02755bbbe21405c11b8
https://doi.org/10.1039/c3md00280b
https://doi.org/10.1039/c3md00280b