Multiscale analysis reveals that diet-dependent midgut plasticity emerges from alterations in both stem cell niche coupling and enterocyte size

Autor: Alessandro Bonfini, Adam J Dobson, David Duneau, Jonathan Revah, Xi Liu, Philip Houtz, Nicolas Buchon

Publikováno v: eLife, Vol 10 (2021)

The gut is the primary interface between an animal and food, but how it adapts to qualitative dietary variation is poorly defined. We find that the Drosophila midgut plastically resizes following changes in dietary composition. A panel of nutrients c

Externí odkaz: https://doaj.org/article/e3a13cacf234480291f8284122088071

Multiscale analysis reveals that diet-dependent midgut plasticity emerges from alterations in both stem cell niche coupling and enterocyte size

Autor: Xi Liu, David Duneau, Adam J. Dobson, Philip Houtz, Nicolas Buchon, Alessandro Bonfini, Jonathan Revah

Publikováno v: eLife
eLife, Vol 10 (2021)

The gut is the primary interface between an animal and food, but how it adapts to qualitative dietary variation is poorly defined. We find that the Drosophila midgut plastically resizes following changes in dietary composition. A panel of nutrients c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b012f170c622ce7fdc892a2c80dd8141
http://europepmc.org/articles/PMC8528489

Microbes affect gut epithelial cell composition through immune-dependent regulation of intestinal stem cell differentiation

Autor: Peter Nagy, Philip Houtz, Xiaowei Yang, Nicolas Buchon, Xiao-Li Bing, Xi Liu, Alessandro Bonfini

Publikováno v: Cell Reports. 38:110572

Gut microbes play important roles in host physiology; however, the mechanisms underlying their impact remain poorly characterized. Here, we demonstrate that microbes not only influence gut physiology but also alter its epithelial composition. The mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e28af6f364b97ee57943b983040dc28
https://doi.org/10.1016/j.celrep.2022.110572

Hippo, TGF-β, and Src-MAPK pathways regulate transcription of the upd3 cytokine in Drosophila enterocytes upon bacterial infection

Autor: Mickael Poidevin, Korneel Hens, Jonathan Revah, Xi Liu, Hsin-Yi Huang, Alessandro Bonfini, Nicolas Buchon, Bart Deplancke, Philip Houtz, Yu-Chen Tsai, Aurélien Guillou

Publikováno v: PLoS Genetics
PLoS Genetics, 2017, 13, pp.e1007091. ⟨10.1371/journal.pgen.1007091⟩
PLoS Genetics, Public Library of Science, 2017, 13, pp.e1007091. ⟨10.1371/journal.pgen.1007091⟩
PLoS Genetics, Vol 13, Iss 11, p e1007091 (2017)

Cytokine signaling is responsible for coordinating conserved epithelial regeneration and immune responses in the digestive tract. In the Drosophila midgut, Upd3 is a major cytokine, which is induced in enterocytes (EC) and enteroblasts (EB) upon oral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ea203ee1107fa9df9fb0e531df50cdb
https://doi.org/10.1371/journal.pgen.1007091

Regional Cell-Specific Transcriptome Mapping Reveals Regulatory Complexity in the Adult Drosophila Midgut

Autor: Jonathan Revah, Christine Gläßer, Adam J. Dobson, Jerome Korzelius, Philip Houtz, Devanjali Dutta, Parthive H. Patel, Bruce A. Edgar, Nicolas Buchon

Publikováno v: Dutta, D, Dobson, A, Houtz, P, Gläßer, C, Revah, J, Korzelius, J, Patel, P H, Edgar, B A & Buchon, N 2015, ' Regional Cell-Specific Transcriptome Mapping Reveals Regulatory Complexity in the Adult Drosophila Midgut ', Cell Reports, vol. 12, no. 2, pp. 346-358 . https://doi.org/10.1016/j.celrep.2015.06.009
Cell Reports, Vol 12, Iss 2, Pp 346-358 (2015)

Deciphering contributions of specific cell types to organ function is experimentally challenging. The Drosophila midgut is a dynamic organ with five morphologically and functionally distinct regions (R1–R5), each composed of multipotent intestinal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2e9d65cbc97964f15a6df99296cc02