Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Philip Hewitt"'
Autor:
Luise A. Roser, Christina Sakellariou, Malin Lindstedt, Vanessa Neuhaus, Susann Dehmel, Charline Sommer, Martin Raasch, Thierry Flandre, Sigrid Roesener, Philip Hewitt, Michael J. Parnham, Katherina Sewald, Susanne Schiffmann
Publikováno v:
Journal of Immunotoxicology, Vol 21, Iss sup1 (2024)
AbstractDrug-induced hepatotoxicity constitutes a major reason for non-approval and post-marketing withdrawal of pharmaceuticals. In many cases, preclinical models lack predictive capacity for hepatic damage in humans. A vital concern is the integrat
Externí odkaz:
https://doaj.org/article/a931852d8d8840f494aa1daaaca9c913
Autor:
Luise A. Roser, Sonja Luckhardt, Nicole Ziegler, Dominique Thomas, Pia Viktoria Wagner, Georg Damm, Andrea Scheffschick, Philip Hewitt, Michael J. Parnham, Susanne Schiffmann
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionHepatotoxicity induced by immunotherapeutics is an appearing cause for immune-mediated drug-induced liver injury. Such immuno-toxic mechanisms are difficult to assess using current preclinical models and the incidence is too low to detect
Externí odkaz:
https://doaj.org/article/d8986d43e74648aabbcdae2dbf5bc4f8
Autor:
Alicia Y. Lim, Yuki Kato, Courtney Sakolish, Alan Valdiviezo, Gang Han, Piyush Bajaj, Jason Stanko, Stephen S. Ferguson, Remi Villenave, Philip Hewitt, Rhiannon N. Hardwick, Ivan Rusyn
Publikováno v:
Bioengineering, Vol 10, Iss 10, p 1195 (2023)
The liver is one of the key organs for exogenous and endogenous metabolism and is often a target for drug- and chemical-driven toxicity. A wide range of experimental approaches has been established to model and characterize the mechanisms of drug- an
Externí odkaz:
https://doaj.org/article/a18304e2256b45029ba33d462bd66feb
Autor:
Valeria Chichagova, Maria Georgiou, Madeleine Carter, Birthe Dorgau, Gerrit Hilgen, Joseph Collin, Rachel Queen, Git Chung, Jila Ajeian, Marina Moya‐Molina, Stefan Kustermann, Francois Pognan, Philip Hewitt, Michael Schmitt, Evelyne Sernagor, Lyle Armstrong, Majlinda Lako
Publikováno v:
Journal of Cellular and Molecular Medicine. 27:435-445
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e355d2946cbd046ef929311d3cdfb0b9
https://doi.org/10.1111/jcmm.17670
https://doi.org/10.1111/jcmm.17670
Autor:
Ivan Rusyn, Courtney Sakolish, Yuki Kato, Clifford Stephan, Leoncio Vergara, Philip Hewitt, Vasanthi Bhaskaran, Myrtle Davis, Rhiannon N Hardwick, Stephen S Ferguson, Jason P Stanko, Piyush Bajaj, Karissa Adkins, Nisha S Sipes, E Sidney Hunter, Maria T Baltazar, Paul L Carmichael, Kritika Sadh, Richard A Becker
Publikováno v:
Toxicol Sci
Much has been written and said about the promise and excitement of microphysiological systems, miniature devices that aim to recreate aspects of human physiology on a chip. The rapid explosion of the offerings and persistent publicity placed high exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5fe00b5247331ff1b276233e30fd420
https://pubmed.ncbi.nlm.nih.gov/35689632
https://pubmed.ncbi.nlm.nih.gov/35689632
Publikováno v:
Applied In Vitro Toxicology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d391e7f6758631ab0356a744ae81cab9
https://doi.org/10.1089/aivt.2023.0004
https://doi.org/10.1089/aivt.2023.0004
Autor:
Felix Rohdich, Stefano Crosignani, Michael Busch, Christina Esdar, Manja Friese-Hamim, Markus Klein, Thomas Fuchss, Oliver Schadt, Djordje Musil, Ugo Zanelli, Michael P. Sanderson, Gina Walter-Bausch, Philip Hewitt, Jeyaprakashnarayanan Seenisamy
Publikováno v:
Journal of Medicinal Chemistry. 64:10230-10245
Proteasomes are broadly expressed key components of the ubiquitin-dependent protein degradation pathway containing catalytically active subunits (β1, β2, and β5). LMP7 (β5i) is a subunit of the immunoproteasome, an inducible isoform that is predo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a3d051fc60306aef1b64a7ba1b3e7b
https://doi.org/10.1021/acs.jmedchem.1c00604
https://doi.org/10.1021/acs.jmedchem.1c00604
Autor:
Yvonne Will, Philip Hewitt, Hartmut Jaeschke, Hilmi Orhan, Mathieu Vinken, Kendall B. Wallace
Publikováno v:
Applied In Vitro Toxicology. 5:167-172
Mitochondria play critical roles in all cell types. They are involved in processes such as calcium storage and signaling, cell proliferation, apoptosis, steroid synthesis, immunity, energy balance, and heat production. Inherent to these vital functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d56f70206754245ddb12c0b59630062f
https://doi.org/10.1089/aivt.2019.29022.rtl
https://doi.org/10.1089/aivt.2019.29022.rtl
Autor:
Philip Hewitt, Nada Abla, Floriane Lignet, Claude Oeuvray, Wilhelmina Bagchus, Lidiya Bebrevska
Publikováno v:
Toxicology and applied pharmacology. 443
M5717 is a novel drug inhibiting synthesis of elongation factor 2 (PeEF2) in Plasmodium species, showing potent anti-malarial activity in preclinical studies. Traditional daily-dosing animal experiments estimating maximum safe starting dose for a fir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45f65d8383d14e151dc7cfc2ee0787f1
https://pubmed.ncbi.nlm.nih.gov/35367236
https://pubmed.ncbi.nlm.nih.gov/35367236
Autor:
Yuki, Kato, Alicia Y, Lim, Courtney, Sakolish, Alan, Valdiviezo, Haley L, Moyer, Philip, Hewitt, Piyush, Bajaj, Gang, Han, Ivan, Rusyn
Publikováno v:
Toxicology in Vitro. 85:105464
Establishing the functionality, reproducibility, robustness, and reliability of microphysiological systems is a critical need for adoption of these technologies. A high throughput microphysiological system for liver studies was recently proposed in w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55bfa095fa212bdcd71f7cb7c781c2fa
https://doi.org/10.1016/j.tiv.2022.105464
https://doi.org/10.1016/j.tiv.2022.105464