Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Philip Heacock"'
Publikováno v:
Journal of Biological Chemistry. 286:15182-15194
The N-terminal six-transmembrane domain (TM) bundle of lactose permease of Escherichia coli is uniformly inverted when assembled in membranes lacking phosphatidylethanolamine (PE). Inversion is dependent on the net charge of cytoplasmically exposed p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51d2fc277fa3a5f7af63b8d9a3f85d16
https://doi.org/10.1074/jbc.m110.214387
https://doi.org/10.1074/jbc.m110.214387
Publikováno v:
Proceedings of the National Academy of Sciences. 107:15057-15062
Phosphatidylcholine (PC) has been widely used in place of naturally occurring phosphatidylethanolamine (PE) in reconstitution of bacterial membrane proteins. However, PC does not support native structure or function for several reconstituted transpor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4a2ed37df86f9ae885913beb1b515c5
https://doi.org/10.1073/pnas.1006286107
https://doi.org/10.1073/pnas.1006286107
Publikováno v:
Journal of Biological Chemistry. 281:19172-19178
To determine the specific role lipids play in membrane protein topogenesis in vivo, the orientation with respect to the membrane bilayer of Escherichia coli lactose permease (LacY) transmembrane (TM) domains and their flanking extramembrane domains w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a056be0948f9b29fd60442f685accd18
https://doi.org/10.1074/jbc.m602565200
https://doi.org/10.1074/jbc.m602565200
Publikováno v:
Journal of Biological Chemistry. 273:14933-14941
In eukaryotic cells, cardiolipin (CL) synthase catalyzes the final step in the synthesis of CL from phosphatidylglycerol and CDP-diacylglycerol. CL and its synthesis are localized predominantly to the mitochondrial inner membrane, and CL is generally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45b45a7b17f085b6ce38bd059d61965c
https://doi.org/10.1074/jbc.273.24.14933
https://doi.org/10.1074/jbc.273.24.14933
Publikováno v:
Journal of Biological Chemistry. 271:789-795
An open reading frame (CDS1) residing on chromosome II of Saccharomyces cerevisiae encodes a hydrophobic protein with a predicted molecular mass of 51,789 Da, which exhibits 29 and 37% amino acid sequence identities with CDP-diacylglycerol synthases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69662d2e2d5838ba919603f58bf08401
https://doi.org/10.1074/jbc.271.2.789
https://doi.org/10.1074/jbc.271.2.789
Autor:
Venkata K. P. S. Mallampalli, Genevieve C. Sparagna, William Dowhan, Soledad Bazán, Philip Heacock, Eugenia Mileykovskaya
Here, we report for the first time in vitro reconstitution of the respiratory supercomplexes from individual complexes III and IV. Complexes III and IV were purified from Saccharomyces cerevisiae mitochondria. Complex III contained eight molecules of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b218f831b94a1fd0f2a9017266c5467a
https://europepmc.org/articles/PMC3537037/
https://europepmc.org/articles/PMC3537037/
Autor:
Christian R. H. Raetz, Jonathan H. Wang, Philip Heacock, Anne N. Murphy, Ji Zhang, Ziqiang Guan, Guy Perkins, Oanh Kim Nguyen, Jack E. Dixon, Sandra E. Wiley, James L. Engel, William Dowhan, Carolyn A. Worby
Publikováno v:
Cell metabolism. 13(6)
SummaryPTPMT1 was the first protein tyrosine phosphatase found localized to the mitochondria, but its biological function was unknown. Herein, we demonstrate that whole body deletion of Ptpmt1 in mice leads to embryonic lethality, suggesting an indis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::889ea1324e8403e25bb12e41626c6231
https://pubmed.ncbi.nlm.nih.gov/21641541
https://pubmed.ncbi.nlm.nih.gov/21641541
Publikováno v:
Methods in Molecular Biology ISBN: 9781603271677
A protocol is described using lipid mutants and thiol-specific chemical reagents to study lipid-dependent and host-specific membrane protein topogenesis by the substituted-cysteine accessibility method as applied to transmembrane domains (SCAMTM). SC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::919a98e5487e0057b72dc11566c4cb90
https://doi.org/10.1007/978-1-60327-412-8_5
https://doi.org/10.1007/978-1-60327-412-8_5
Autor:
Xue Li Guan, Philip Heacock, William Dowhan, Stephan Kutik, Peter Rehling, Michael Rissler, Natalia Gebert, Nils Wiedemann, Bernard Guiard, Nikolaus Pfanner, Markus R. Wenk, Guanghou Shui
Publikováno v:
The Journal of Cell Biology
The mitochondrial inner membrane contains different translocator systems for the import of presequence-carrying proteins and carrier proteins. The translocator assembly and maintenance protein 41 (Tam41/mitochondrial matrix protein 37) was identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f5d0c072fec28fc673906a423fc1da2
https://pubmed.ncbi.nlm.nih.gov/19114592
https://pubmed.ncbi.nlm.nih.gov/19114592
Autor:
Philip Heacock, Jun Xie, M. Wikstrom, Mikhail Bogdanov, Eugenia Mileykovskaya, William Dowhan, Åke Wieslander
Publikováno v:
The Journal of biological chemistry. 279(11)
The mechanisms by which lipid bilayer properties govern or influence membrane protein functions are little understood, but a liquid-crystalline state and the presence of anionic and nonbilayer (NB)-prone lipids seem important. An Escherichia coli mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c66099fddba2a42246f015c5701c10dc
https://pubmed.ncbi.nlm.nih.gov/14688287
https://pubmed.ncbi.nlm.nih.gov/14688287