Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Philip Hartz"'
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102504- (2023)
Summary: tRNA-bound amino acids often need to be identified, for instance, in cases where different amino acids compete for binding to the same tRNA. Here, we present a mass-spectrometry-based protocol to determine the amino acids bound to tRNA by am
Externí odkaz:
https://doaj.org/article/bb2329d923ec450bbcd8f1f04fee2b63
Autor:
Polina Petkova-Kirova, Stephan Baas, Gudrun Wagenpfeil, Philip Hartz, Marcus Michael Unger, Rita Bernhardt
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Parkinson’s disease (PD) is one of the most frequent neurological diseases affecting millions of people worldwide. While the majority of PD cases are of unknown origin (idiopathic), about 5%–10% are familial and linked to mutations in different k
Externí odkaz:
https://doaj.org/article/a7bd44d9ad094420bffb69c4132d6fa4
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2023)
Genetic and environmental factors lead to the manifestation of Parkinson’s disease (PD) but related mechanisms are only rudimentarily understood. Cytochromes P450 (P450s) are involved in the biotransformation of toxic compounds and in many physiolo
Externí odkaz:
https://doaj.org/article/edb2071e2e584ffdb6c8816e3d847289
The canonical set of amino acids leads to an exceptionally wide range of protein functionality, nevertheless, this set still exhibits limitations. The incorporation of noncanonical amino acids into proteins can enlarge its functional scope. Although
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d30d4f85fc2890ea026def8c8c6b98e
Publikováno v:
Journal of Biotechnology. 294:38-48
Over the past decades, Bacillus megaterium has gained significant interest in the biotechnological industry due to its high capacity for protein production. Although many proteins have been expressed efficiently using the optimized xylose inducible s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52c924b6970ea4672939081b75da4b71
https://doi.org/10.1016/j.jbiotec.2019.01.018
https://doi.org/10.1016/j.jbiotec.2019.01.018
Autor:
Frank Hannemann, Rita Bernhardt, Michael C. Hutter, Ammar Abdulmughni, Basma M. EL‐Gayar, Elizabeth M. J. Gillam, Silja J. Strohmaier, Philip Hartz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a1179c712517eb26792ca920aa23df0
https://doi.org/10.1111/febs.16054/v2/response1
https://doi.org/10.1111/febs.16054/v2/response1
Autor:
Philip Hartz, Basma M. EL‐Gayar, Rita Bernhardt, Ammar Abdulmughni, Michael C. Hutter, Silja J. Strohmaier, Elizabeth M. J. Gillam, Frank Hannemann
Publikováno v:
The FEBS journalReferences. 288(22)
Mitochondrial cytochromes P450 presumably originated from a common microsomal P450 ancestor. However, it is still unknown how ancient mitochondrial P450s were able to retain their oxygenase function following relocation to the mitochondrial matrix an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cfbf2fafe1366dfae1b170e0880805c
https://pubmed.ncbi.nlm.nih.gov/34092040
https://pubmed.ncbi.nlm.nih.gov/34092040
Autor:
Rita Bernhardt, Philip Hartz, Natalia Putkaradze, Michael C. Hutter, Mario Thevis, Josef Zapp
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 212
The human microsomal cytochrome P450 enzyme CYP46A1 plays a crucial role in cholesterol elimination from the brain. It performs a 24-hydroxylation of cholesterol and is of outstanding significance for memory and cognition. This study demonstrates the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acb9edd6142c34adcb895c50b7650dc8
https://pubmed.ncbi.nlm.nih.gov/34089835
https://pubmed.ncbi.nlm.nih.gov/34089835
Publikováno v:
Journal of biotechnology. 329
Bacillus megaterium has become increasingly important for the biotechnological production of valuable compounds of industrial and pharmaceutical importance. Despite recent advances in rational strain design of B. megaterium, these studies have been l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a237f82429b3c205382e3764294ca2df
https://pubmed.ncbi.nlm.nih.gov/33600891
https://pubmed.ncbi.nlm.nih.gov/33600891
Autor:
Fredy Kern, Philip Hartz, Rita Bernhardt, Mohammed Milhim, Ammar Abdulmughni, Natalia Putkaradze
Publikováno v:
Journal of Biotechnology. 240:68-75
In the current work, we describe the identification and characterization of the first plasmid-encoded P450 (CYP107DY1) from a Bacillus species. The recombinant CYP107DY1 exhibits characteristic P450 absolute and reduced CO-bound difference spectra. R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab55c625f65798678f75a652b9bf3237
https://doi.org/10.1016/j.jbiotec.2016.11.002
https://doi.org/10.1016/j.jbiotec.2016.11.002