Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Philip H. Milliken"'
Voiding behavior in awake unrestrained untethered spontaneously hypertensive and Wistar control rats
Publikováno v:
American Journal of Physiology-Renal Physiology. 321:F195-F206
The spontaneously hypertensive rat (SHR), a genetic model of high blood pressure, has also been studied as a potential model of overactive bladder. In vivo studies have confirmed the presence of surrogate markers of overactive bladder, including detr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8be71d4c43b181c51073abd8ebbd7c84
https://doi.org/10.1152/ajprenal.00564.2020
https://doi.org/10.1152/ajprenal.00564.2020
Publikováno v:
American Journal of Physiology-Renal Physiology. 320:F212-F223
Prostaglandin E2 (PGE2) instilled into the bladder generates symptoms of urinary urgency in healthy women and reduces bladder capacity and urethral pressure in both humans and female rats. Systemic capsaicin desensitization, which causes degeneration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3dc947b5dfdb9334708072a98a125e0
https://doi.org/10.1152/ajprenal.00302.2020
https://doi.org/10.1152/ajprenal.00302.2020
Publikováno v:
American Journal of Physiology-Renal Physiology. 318:F1357-F1368
Selective electrical stimulation of the pudendal nerve exhibits promise as a potential therapy for treating overactive bladder (OAB) across species (rats, cats, and humans). More recently, pelvic nerve (PelN) stimulation was demonstrated to improve c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c15f4a09e71cb8e1f60e24fa7d0aab0
https://doi.org/10.1152/ajprenal.00068.2020
https://doi.org/10.1152/ajprenal.00068.2020
Autor:
Adam Hargreaves, Rob Wallis, Derek J. Leishman, Louise Leong, Steven Engle, Lorna Ewart, David E. Watson, Kathleen M. Heinz-Taheny, Philip H. Milliken, Nick McMahon, Sarah Kirk, Peter Clements, Mike Aylott, Jean-Pierre Valentin, Magali Guffroy, Renaud Fleurance, Nick Edmunds
Publikováno v:
Toxicological Sciences. 176:224-235
Integrating nonclinical in vitro, in silico, and in vivo datasets holistically can improve hazard characterization and risk assessment. In pharmaceutical development, cardiovascular liabilities are a leading cause of compound attrition. Prior to clin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2764b1583d31e2aea76a3e12dabc3e8
https://doi.org/10.1093/toxsci/kfaa051
https://doi.org/10.1093/toxsci/kfaa051
Autor:
James A, Hokanson, Christopher L, Langdale, Philip H, Milliken, Arun, Sridhar, Warren M, Grill
Publikováno v:
Am J Physiol Renal Physiol
Prostaglandin E(2) (PGE(2)) instilled into the bladder generates symptoms of urinary urgency in healthy women and reduces bladder capacity and urethral pressure in both humans and female rats. Systemic capsaicin desensitization, which causes degenera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b994c247e2326a482ab4f24c236e9098
https://pubmed.ncbi.nlm.nih.gov/33283648
https://pubmed.ncbi.nlm.nih.gov/33283648
Autor:
Philip H Milliken, Nobuhiro Watanabe, Stephen J. Lewis, Arun Sridhar, Yee-Hsee Hsieh, Kaori Iimura, Harumi Hotta
Publikováno v:
Biomedicines
Volume 8
Issue 9
Biomedicines, Vol 8, Iss 369, p 369 (2020)
Volume 8
Issue 9
Biomedicines, Vol 8, Iss 369, p 369 (2020)
Electrical stimulation of myelinated afferent fibers of the superior laryngeal nerve (SLN) facilitates calcitonin secretion from the thyroid gland in anesthetized rats. In this study, we aimed to quantify the electrical SLN stimulation-induced system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f4df1734659a03183b7af82880cef7d
http://europepmc.org/articles/PMC7555126
http://europepmc.org/articles/PMC7555126
Autor:
Christopher L, Langdale, James A, Hokanson, Philip H, Milliken, Arun, Sridhar, Warren M, Grill
Publikováno v:
Am J Physiol Renal Physiol
Selective electrical stimulation of the pudendal nerve exhibits promise as a potential therapy for treating overactive bladder (OAB) across species (rats, cats, and humans). More recently, pelvic nerve (PelN) stimulation was demonstrated to improve c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e76771a170d54a00ea927012944d980c
https://pubmed.ncbi.nlm.nih.gov/32308021
https://pubmed.ncbi.nlm.nih.gov/32308021
Autor:
Elisabeth Mortimer-Cassen, Kathryn Costelloe, Robert M. Owen, R. Ian Storer, Philip H. Milliken, Magda Bictash, Gianna Toschi, Andrew Pike, Hannah J. Pearce, Emma Impey, Benjamin A. Pibworth, Caroline L. Benn, Emma Armstrong, David C. Blakemore
Publikováno v:
MedChemComm. 7:1587-1595
Elevated serum uric acid levels can lead to gout which remains an area of unmet medical need. Following an unexpected clinical uricosuric effect observed with a sulfonamide compound, PF-05089771 (9), subsequently attributed to weak URAT1 inhibition,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3b504efc1e2494b2c9703a3bd2ca6da
https://doi.org/10.1039/c6md00190d
https://doi.org/10.1039/c6md00190d
Publikováno v:
Frontiers in Neuroscience
Frontiers in Neuroscience, Vol 11 (2017)
Frontiers in Neuroscience, Vol 11 (2017)
The thyroid and parathyroid glands are dually innervated by sympathetic (cervical sympathetic trunk [CST]) and parasympathetic (superior laryngeal nerve [SLN]) nerve fibers. We examined the effects of electrical stimulation of efferent or afferent ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::415dfa0dbe899ab8c7420ae2f857980f
Reduced NO levels due to the deficiency of tetrahydrobiopterin (BH(4)) contribute to impaired vasodilation in pulmonary hypertension. Due to the chemically unstable nature of BH(4), it was hypothesised that oxidatively stable analogues of BH(4) would
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3a7da4f573c8de29484c5ff5d9a1fef
https://strathprints.strath.ac.uk/31258/1/Tetrahydrobiopterin_analogues_with_NO_dependent.pdf
https://strathprints.strath.ac.uk/31258/1/Tetrahydrobiopterin_analogues_with_NO_dependent.pdf
