Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Philip H. Karp"'
Autor:
Lei Lei, Soumba Traore, Guillermo S. Romano Ibarra, Philip H. Karp, Tayyab Rehman, David K. Meyerholz, Joseph Zabner, David A. Stoltz, Patrick L. Sinn, Michael J. Welsh, Paul B. McCray Jr., Ian M. Thornell
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 20 (2023)
The volume and composition of a thin layer of liquid covering the airway surface defend the lung from inhaled pathogens and debris. Airway epithelia secrete Cl– into the airway surface liquid through cystic fibrosis transmembrane conductance regula
Externí odkaz:
https://doaj.org/article/2cd2777105f44a3382766c3e36dc6f28
Autor:
Miguel E. Ortiz, Andrew Thurman, Alejandro A. Pezzulo, Mariah R. Leidinger, Julia A. Klesney-Tait, Philip H. Karp, Ping Tan, Christine Wohlford-Lenane, Paul B. McCray, Jr., David K. Meyerholz
Publikováno v:
EBioMedicine, Vol 60, Iss , Pp 102976- (2020)
Background: Zoonotically transmitted coronaviruses are responsible for three disease outbreaks since 2002, including the current COVID-19 pandemic, caused by SARS-CoV-2. Its efficient transmission and range of disease severity raise questions regardi
Externí odkaz:
https://doaj.org/article/aca39e31195e472f99e4e21970a117e7
Autor:
Tayyab Rehman, Philip H. Karp, Andrew L. Thurman, Steven E. Mather, Akansha Jain, Ashley L. Cooney, Patrick L. Sinn, Alejandro A. Pezzulo, Michael E. Duffey, Michael J. Welsh
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 67:491-502
In cystic fibrosis (CF), reduced HCOsub3/subsup-/supsecretion acidifies the airway surface liquid (ASL), and the acidic pH disrupts host defenses. Thus, understanding the control of ASL pH (pHsubASL/sub) in CF may help identify novel targets and faci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d8b1f9bffca58e51ad561baf9bb5a3b
https://doi.org/10.1165/rcmb.2022-0172oc
https://doi.org/10.1165/rcmb.2022-0172oc
Autor:
Michael J. Welsh, Janice L. Launspach, Martin D. Burke, Rajeev S. Chorghade, Philip H. Karp, Bo Ram Kim
Publikováno v:
J Cyst Fibros
Background Approximately 10% of people with cystic fibrosis (CF) have mutations that result in little to no CFTR production and thus cannot benefit from CFTR modulators. We previously found that Amphotericin B (AmB), a small molecule that forms anion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70b946f93a70763d56f9255377861308
https://doi.org/10.1016/j.jcf.2020.11.018
https://doi.org/10.1016/j.jcf.2020.11.018
Autor:
Ian M. Thornell, Ping Tan, Tayyab Rehman, Michael E. Duffey, Guillermo S Romano Ibarra, Alejandro A. Pezzulo, Philip H. Karp, Andrew L Thurman, Michael J. Welsh
Publikováno v:
American Journal of Physiology-Cell Physiology
The pH of airway surface liquid (ASL) is a key factor that determines respiratory host defense; ASL acidification impairs and alkalinization enhances key defense mechanisms. Under healthy conditions, airway epithelia secrete base ([Formula: see text]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b8dce1ac5ddec6cb310439104be1963
https://doi.org/10.1152/ajpcell.00112.2020
https://doi.org/10.1152/ajpcell.00112.2020
Autor:
Bo Ram Kim, Alexander G. Cioffi, Michael J. Welsh, Katrina A. Muraglia, Martin D. Burke, Lingyang Zhu, Viral Shah, Page N. Daniels, Philip H. Karp, Rajeev S. Chorghade, Xiao Xiao Tang, Anthony S. Grillo
Publikováno v:
Nature
Loss-of-function mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) compromise epithelial HCO3− and Cl− secretion, reduce airway surface liquid pH, and impair respiratory host defences in people with cystic fibrosis1–3.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::892ef4792b26cec12d9fad96b01e121e
http://europepmc.org/articles/PMC6492938
http://europepmc.org/articles/PMC6492938
Autor:
Ping Tan, Alejandro A. Pezzulo, Tayyab Rehman, Ian M. Thornell, Michael J. Welsh, S.L. Durfey, Andrew L Thurman, Brian J Goodell, Edward F. McKone, David A. Stoltz, Michael E. Duffey, Philip H. Karp, Pradeep K. Singh
Publikováno v:
J Clin Invest
Without cystic fibrosis transmembrane conductance regulator–mediated (CFTR-mediated) HCO(3)(–) secretion, airway epithelia of newborns with cystic fibrosis (CF) produce an abnormally acidic airway surface liquid (ASL), and the decreased pH impair
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b1d348bde61d18690e24e69181bf01a
https://pubmed.ncbi.nlm.nih.gov/34166230
https://pubmed.ncbi.nlm.nih.gov/34166230
Autor:
Erica N. LeClair, David A. Stoltz, Nicholas D. Gansemer, Katherine N. Gibson-Corley, Paul B. McCray, Michael J. Welsh, Mariah R. Leidinger, Sarah E. Ernst, Carrie K. Barker, Matthew D. Strub, Ryan J. Adam, Daniel P. Cook, Philip H. Karp, David K. Meyerholz
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology
Loss of cystic fibrosis transmembrane conductance regulator (CFTR) function causes cystic fibrosis (CF), predisposing the lungs to chronic infection and inflammation. In young infants with CF, structural airway defects are increasingly recognized bef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd7b924e768383966392ca32bdd8d29
https://doi.org/10.1038/s41374-018-0026-7
https://doi.org/10.1038/s41374-018-0026-7
Autor:
Joseph Zabner, Xiaopeng Li, Christian M Brommel, R. Villacreses Rada, Annie Ehler, Steven E Mather, Michael J. Welsh, Ian M. Thornell, Lin Lu, Philip H. Karp
Publikováno v:
A108. PATHOPHYSIOLOGY IN DIFFUSE PARENCHYMAL LUNG DISEASES.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4cc30e6a2733210128670fd905c737c
https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2573
https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2573
Autor:
Viral Shah, Michael J. Welsh, Lynda S. Ostedgaard, Philip H. Karp, Xiao Xiao Tang, Sarah E. Ernst, Connor P. Parker
Publikováno v:
Proceedings of the National Academy of Sciences. 113:5382-5387
Cystic fibrosis (CF) is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel. Airway disease is the major source of morbidity and mortality. Successful implementation of gene- and cell-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46213af8c5fe2a7f6617c60eb19d591d
https://doi.org/10.1073/pnas.1604905113
https://doi.org/10.1073/pnas.1604905113