Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis

Autor: John A. Lees, Bart Ferwerda, Philip H. C. Kremer, Nicole E. Wheeler, Mercedes Valls Serón, Nicholas J. Croucher, Rebecca A. Gladstone, Hester J. Bootsma, Nynke Y. Rots, Alienke J. Wijmega-Monsuur, Elisabeth A. M. Sanders, Krzysztof Trzciński, Anne L. Wyllie, Aeilko H. Zwinderman, Leonard H. van den Berg, Wouter van Rheenen, Jan H. Veldink, Zitta B. Harboe, Lene F. Lundbo, Lisette C. P. G. M. de Groot, Natasja M. van Schoor, Nathalie van der Velde, Lars H. Ängquist, Thorkild I. A. Sørensen, Ellen A. Nohr, Alexander J. Mentzer, Tara C. Mills, Julian C. Knight, Mignon du Plessis, Susan Nzenze, Jeffrey N. Weiser, Julian Parkhill, Shabir Madhi, Thomas Benfield, Anne von Gottberg, Arie van der Ende, Matthijs C. Brouwer, Jeffrey C. Barrett, Stephen D. Bentley, Diederik van de Beek

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

Streptococcus pneumoniae is a causative agent of meningitis and bacteremia. In a combined pathogen and host GWAS, Lees et al. find that host genetic variation is associated with both susceptibility and severity of pneumococcal meningitis, and specifi

Externí odkaz: https://doaj.org/article/676c4fca20864aaa9d086a45a85f61c3

Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis

Autor: Anne von Gottberg, Jan H. Veldink, Wouter van Rheenen, Nynke Y. Rots, Lars Ängquist, Anne L. Wyllie, Lisette C. P. G. M. de Groot, Hester J. Bootsma, Ellen A. Nohr, Lene Fogt Lundbo, Rebecca A. Gladstone, Susan A. Nzenze, Thomas Benfield, Aeilko H. Zwinderman, Julian C. Knight, Jeffrey N. Weiser, Krzysztof Trzciński, Nicholas J. Croucher, Shabir Madhi, Mignon du Plessis, Thorkild I. A. Sørensen, Tara C. Mills, Bart Ferwerda, Elisabeth A. M. Sanders, Nicole E. Wheeler, Diederik van de Beek, Philip H. C. Kremer, Jeffrey C. Barrett, Alexander J. Mentzer, Stephen D. Bentley, Matthijs C. Brouwer, Mercedes Valls Serón, Nathalie van der Velde, Alienke J. Wijmega-Monsuur, Leonard H. van den Berg, Arie van der Ende, Zitta Barrella Harboe, Natasja M. van Schoor, Julian Parkhill, John A. Lees

Publikováno v: Nature Communications, 10:2176. Nature Publishing Group
Nature Communications 10 (2019) 1
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Lees, J A, Ferwerda, B, Kremer, P H C, Wheeler, N E, Serón, M V, Croucher, N J, Gladstone, R A, Bootsma, H J, Rots, N Y, Wijmega-Monsuur, A J, Sanders, E A M, Trzciński, K, Wyllie, A L, Zwinderman, A H, van den Berg, L H, van Rheenen, W, Veldink, J H, Harboe, Z B, Lundbo, L F, de Groot, L C P G M, van Schoor, N M, van der Velde, N, Ängquist, L H, Sørensen, T I A, Nohr, E A, Mentzer, A J, Mills, T C, Knight, J C, du Plessis, M, Nzenze, S, Weiser, J N, Parkhill, J, Madhi, S, Benfield, T, von Gottberg, A, van der Ende, A, Brouwer, M C, Barrett, J C, Bentley, S D & van de Beek, D 2019, ' Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis ', Nature Communications, vol. 10, 2176 . https://doi.org/10.1038/s41467-019-09976-3
Lees, J A, Ferwerda, B, Kremer, P H C, Wheeler, N E, Seron, M V, Croucher, N J, Gladstone, R A, Bootsma, H J, Rots, N Y, Wijmega-Monsuur, A J, Sanders, E A M, Trzcinski, K, Wyllie, A L, Zwinderman, A H, van den Berg, L H, van Rheenen, W, Veldink, J H, Harboe, Z B, Lundbo, L F, de Groot, L C P G M, van Schoor, N M, van der Velde, N, Angquist, L H, Sørensen, T I A, Nohr, E A, Mentzer, A J, Mills, T C, Knight, J C, du Plessis, M, Nzenze, S, Weiser, J N, Parkhill, J, Madhi, S, Benfield, T, von Gottberg, A, van der Ende, A, Brouwer, M C, Barrett, J C, Bentley, S D & van de Beek, D 2019, ' Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis ', Nature Communications, vol. 10, 2176 . https://doi.org/10.1038/s41467-019-09976-3
Nature Communications, 10(1):2176. Nature Publishing Group UK
Nature Communications
Nature communications, 10(1):2176. Nature Publishing Group
Lees, J A, Ferwerda, B, Kremer, P H C, Wheeler, N E, Serón, M V, Croucher, N J, Gladstone, R A, Bootsma, H J, Rots, N Y, Wijmega-Monsuur, A J, Sanders, E A M, Trzciński, K, Wyllie, A L, Zwinderman, A H, van den Berg, L H, van Rheenen, W, Veldink, J H, Harboe, Z B, Lundbo, L F, de Groot, L C P G M, van Schoor, N M, van der Velde, N, Ängquist, L H, Sørensen, T I A, Nohr, E A, Mentzer, A J, Mills, T C, Knight, J C, du Plessis, M, Nzenze, S, Weiser, J N, Parkhill, J, Madhi, S, Benfield, T, von Gottberg, A, van der Ende, A, Brouwer, M C, Barrett, J C, Bentley, S D & van de Beek, D 2019, ' Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis ', Nature Communications, vol. 10, no. 1, 2176 . https://doi.org/10.1038/s41467-019-09976-3
Nature Communications, 10(1)

Streptococcus pneumoniae is a common nasopharyngeal colonizer, but can also cause life-threatening invasive diseases such as empyema, bacteremia and meningitis. Genetic variation of host and pathogen is known to play a role in invasive pneumococcal d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ee6d7584fa83d9ebe796545bc02603c
https://www.repository.cam.ac.uk/handle/1810/294917

Large scale genomic analysis shows no evidence for pathogen adaptation between the blood and cerebrospinal fluid niches during bacterial meningitis

Autor: John A. Lees, Marco R. Oggioni, Bart Ferwerda, Diederik van de Beek, Stephen D. Bentley, Nicholas J. Croucher, Matthijs C. Brouwer, Ana Sousa Manso, Mercedes Valls Serón, Philip H. C. Kremer, Julian Parkhill, Arie van der Ende

Publikováno v: Microbial genomics, 3(1). Microbiology Society
Microbial Genomics

Recent studies have provided evidence for rapid pathogen genome diversification, some of which could potentially affect the course of disease. We have previously described such variation seen between isolates infecting the blood and cerebrospinal flu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::957ebb4fbefd75c6cfb7d1eaa3e2a95e
https://doi.org/10.1099/mgen.0.000103

Large scale genomic analysis shows no evidence for repeated pathogen adaptation during the invasive phase of bacterial meningitis in humans

Autor: Philip H. C. Kremer, Marco R. Oggioni, Diederik van de Beek, Ana Sousa Manso, Nicholas J. Croucher, Julian Parkhill, Mercedes Valls Serón, Arie van der Ende, John A. Lees, Matthijs C. Brouwer, Bart Ferwerda, Stephen D. Bentley

Recent studies have provided evidence for rapid pathogen genome variation, some of which could potentially affect the course of disease. We have previously detected such variation by comparing isolates infecting the blood and cerebrospinal fluid (CSF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e609acf27dfe0f1737613542fbedb5

Therapeutic hypothermia and the risk of infection: a systematic review and meta-analysis

Autor: H. Bart van der Worp, Rainer Kollmar, Philip H C Kremer, Malcolm R. Macleod, Marjolein Geurts

Publikováno v: Critical care medicine. 42(2)

Observational studies suggest that infections are a common complication of therapeutic hypothermia. We performed a systematic review and meta-analysis of randomized trials to examine the risk of infections in patients treated with hypothermia.PubMed,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b16dfb90a75100b7c4e9d5b04f12c18
https://pubmed.ncbi.nlm.nih.gov/24434441