Výsledky vyhledávání - "Philip Gerrard"

Autor: Renzo Carletti, Stefano Tacconi, Manolo Mugnaini, Philip Gerrard

Publikováno v: Current opinion in pharmacology. 35

Receptor distribution studies have played a key role in the characterization of receptor systems (e.g. GABAB, NMDA (GluNRs), and Neurokinin 1) and in generating hypotheses to exploit these systems as potential therapeutic targets. Distribution studie

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https://pubmed.ncbi.nlm.nih.gov/28803835

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Identification, biological characterization and pharmacophoric analysis of a new potent and selective NK1 receptor antagonist clinical candidate

Autor: Alessandro Poffe, Simone Spada, Carla Marchioro, Mauro Corsi, Romano Di Fabio, Michael Trower, Philip Gerrard, Giuseppe Alvaro, Simone Braggio, Cristiana Griffante, Laura Piccoli, Elvira Tranquillini, Sergio Melotto, Alfonso Pozzan, Emiliangelo Ratti, Renzo Carletti

Publikováno v: Bioorganic & Medicinal Chemistry. 21:6264-6273

The last two decades have provided a large weight of preclinical data implicating the neurokinin-1 receptor (NK1) and its cognate ligand substance P (SP) in a broad range of both central and peripheral disease conditions. However, to date, only the N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0fd9c1bc1f4b01e93ee46681247a383
https://doi.org/10.1016/j.bmc.2013.09.001

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Discovery and Biological Characterization of (2R,4S)-1′-Acetyl-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4,4′-bipiperidine-1-carboxamide as a New Potent and Selective Neurokinin 1 (NK1) Receptor Antagonist Clinical Candidate

Autor: Romano Di Fabio, Emiliangelo Ratti, Sergio Melotto, Mauro Corsi, Laura Zonzini, Giuseppe Alvaro, Daniele Donati, Cristiana Griffante, Domenica Antonia Pizzi, Zadeo Cimarosti, Stefano Provera, Philip Gerrard, David G. Trist, Giuseppe Guercio, Carla Marchioro, Dino Montanari, Mario Mattioli

Publikováno v: Journal of Medicinal Chemistry. 54:1071-1079

A large body of compelling preclinical evidence supports the clinical use of neurokinin (NK) receptor antagonists in a plethora of CNS and non-CNS therapeutic areas. The significant investment made in this area over the past 2 decades culminated with

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https://doi.org/10.1021/jm1013264

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Discovery Process and Pharmacological Characterization of 2-(S)-(4-Fluoro-2-methylphenyl)piperazine-1-carboxylic Acid [1-(R)-(3,5-Bis-trifluoromethylphenyl)ethyl]methylamide (Vestipitant) as a Potent, Selective, and Orally Active NK1 Receptor Antagonist

Autor: Laura Zonzini, Giuseppe Alvaro, Stefano Provera, Giorgio Pentassuglia, Daniele Donati, Cristiana Griffante, Zadeo Cimarosti, Giuseppe Guercio, Carla Marchioro, Romano Di Fabio, Mario Mattioli, David G. Trist, Dino Montanari, Mauro Corsi, Philip Gerrard, Domenica Antonia Pizzi, Emiliangelo Ratti, Tino Rossi, Sergio Melotto

Publikováno v: Journal of Medicinal Chemistry. 52:3238-3247

In an effort to discover novel druglike NK1 receptor antagonists a new series of suitably substituted C-phenylpiperazine derivatives was identified by an appropriate chemical exploration of related N-phenylpiperazine analogues, with the specific aim

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https://doi.org/10.1021/jm900023b

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An analysis of main and subsidiary credit card holding and spending

Autor: James F. Devlin, Steve Worthington, Philip Gerrard

Publikováno v: International Journal of Bank Marketing. 25:89-101

PurposeThis study seeks to examine why most multiple credit cardholders have a “main” card (i.e. a card used more often than others) and “subsidiary” cards (i.e. cards used less often or only in an emergency) and the spending patterns associa

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https://doi.org/10.1108/02652320710728429

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Correlation between serum ghrelin levels and cocaine-seeking behaviour triggered by cocaine-associated conditioned stimuli in rats

Autor: Francesca Marini, Christian Heidbreder, Michela Tessari, Antonio Catalano, Sergio Melotto, Carla Di Francesco, Philip Gerrard, Michele Pellitteri

Publikováno v: Addiction Biology. 12:22-29

Ghrelin is a brain-gut peptide with growth hormone-releasing and appetite-inducing activities. A growing body of evidence suggests that ghrelin may affect the central reward system and modulate the activity of the mesolimbic system. Recent clinical s

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https://doi.org/10.1111/j.1369-1600.2007.00052.x

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The NK1 receptor antagonist aprepitant attenuates NK1 agonist-induced scratching behaviour in the gerbil after intra-dermal, topical or oral administration

Autor: Vivian J A Costantini, Laura Zonzini, Letizia Bettelini, Mauro Corsi, Philip Gerrard, Georg Dünstl

Publikováno v: Experimental dermatology. 24(4)

Experiments were conducted to develop a model to study the effect of oral and topical administration of the NK1 receptor antagonist aprepitant, on scratching behaviour in gerbils. The gerbil was selected due to its relevance for human NK1 receptor ph

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https://pubmed.ncbi.nlm.nih.gov/25650546

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Why consumers are not using internet banking: a qualitative study

Autor: Philip Gerrard, J. Barton Cunningham, James F. Devlin

Publikováno v: Journal of Services Marketing. 20:160-168

PurposeThis paper illustrates why consumers are resistant to using internet banking.Design/methodology/approachA survey was used to acquire data from 127 consumers who were not internet bank users.FindingsUsing a content analysis procedure, eight fac

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https://doi.org/10.1108/08876040610665616

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Moneychangers: an appraisal of their service

Autor: Philip Gerrard, J. Barton Cunningham

Publikováno v: International Journal of Retail & Distribution Management. 33:749-765

PurposeThis study aims to develop a set of dimensions for measuring the service of moneychangers.Design/methodology/approachAttributes for measuring the moneychanger service were created from exit interviews and a review of the literature, and then a

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https://doi.org/10.1108/09590550510622290

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