Výsledky vyhledávání - "Philip G. Woodman"

Akademický článek

Membrane trafficking in health and disease

Autor: Rebecca Yarwood, John Hellicar, Philip G. Woodman, Martin Lowe

Publikováno v: Disease Models & Mechanisms, Vol 13, Iss 4 (2020)

Membrane trafficking pathways are essential for the viability and growth of cells, and play a major role in the interaction of cells with their environment. In this At a Glance article and accompanying poster, we outline the major cellular traffickin

Externí odkaz: https://doaj.org/article/50a7587631234ec19630dd7735debfac

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Akademický článek

The flexibility and dynamics of the tubules in the endoplasmic reticulum

Autor: Pantelis Georgiades, Victoria J. Allan, Graham D. Wright, Philip G. Woodman, Parinya Udommai, Manloeng A. Chung, Thomas A. Waigh

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)

Abstract The endoplasmic reticulum (ER) is a single organelle in eukaryotic cells that extends throughout the cell and is involved in a large number of cellular functions. Using a combination of fixed and live cells (human MRC5 lung cells) in diffrac

Externí odkaz: https://doaj.org/article/bc9000eb178b46f8b13849ab3ee4c145

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The meiotic LINC complex component KASH5 is an activating adaptor for cytoplasmic dynein

Autor: Kirsten E.L. Garner, Anna Salter, Clinton K. Lau, Manickam Gurusaran, Cécile M. Villemant, Elizabeth P. Granger, Gavin McNee, Philip G. Woodman, Owen R. Davies, Brian E. Burke, Victoria J. Allan

Publikováno v: Garner, K E L, Salter, A, Lau, C K, Gurusaran, M, Villemant, C M, Granger, E P, McNee, G, Woodman, P G, Davies, O R, Burke, B E & Allan, V J 2023, ' The meiotic LINC complex component KASH5 is an activating adaptor for cytoplasmic dynein ', The Journal of cell biology, vol. 222, no. 5, e202204042 . https://doi.org/10.1083/jcb.202204042

Cytoplasmic dynein-driven movement of chromosomes during prophase I of mammalian meiosis is essential for synapsis and genetic exchange. Dynein connects to chromosome telomeres via KASH5 and SUN1 or SUN2, which together span the nuclear envelope. Her

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5fcf27c3c178a3e452b9a8c139176f6
https://doi.org/10.1101/2022.04.13.488131

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His domain protein tyrosine phosphatase and Rabaptin-5 couple endo-lysosomal sorting of EGFR with endosomal maturation

Autor: Ling Zhang, Peristera Roboti, Sandra Taylor, Philip G. Woodman, Gabrielle Parkinson

Publikováno v: Journal of Cell Science
article-version (VoR) Version of Record

His domain protein tyrosine phosphatase (HD-PTP; also known as PTPN23) collaborates with endosomal sorting complexes required for transport (ESCRTs) to sort endosomal cargo into intralumenal vesicles, forming the multivesicular body (MVB). Completion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::336dcb915d8e70bf5a268abcf47334e2
https://doi.org/10.1242/jcs.259192

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Endosomal recycling tubule scission and integrin recycling involve the membrane curvature-supporting protein LITAF

Autor: Martin Lowe, Wenxia Qin, Rebecca Yarwood, Philip G. Woodman, Lydia Wunderley, Ling Zhang

Publikováno v: Journal of Cell Science
article-version (VoR) Version of Record

Recycling to the cell surface requires the scission of tubular membrane intermediates emanating from endosomes. Here, we identify the monotopic membrane protein LPS-induced TNF-activating factor (LITAF) and the related protein cell death involved p53

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e4fe6a65faabce1cbcba1f86b8facef
https://doi.org/10.1242/jcs.258549

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Environmental control of Pub1 (NEDD4 family E3 ligase) in S. pombe is regulated by TORC2 and Gsk3

Autor: Janni Petersen, Philip G. Woodman, Tingting Wang, Sean J. Humphrey

Cells respond to changing nutrient environments by adjusting the abundance of surface nutrient transporters and receptors. This can be achieved by modulating ubiquitin-dependent endocytosis, which in part is regulated by the NEDD4 family of E3 ligase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68c12b2648e4e4eb09ccf116c97f9e1f
https://doi.org/10.1101/2021.02.21.432158

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Membrane trafficking in health and disease

Autor: Philip G. Woodman, John Hellicar, Martin Lowe, Rebecca Yarwood

Publikováno v: Yarwood, R, Hellicar, J, Woodman, P G & Lowe, M 2020, ' Membrane trafficking in health and disease ', Disease Models & Mechanisms . https://doi.org/10.1242/dmm.043448
Disease Models & Mechanisms
article-version (VoR) Version of Record
Disease Models & Mechanisms, Vol 13, Iss 4 (2020)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3725303971d55e5c28174006c9faf772
https://doi.org/10.1242/dmm.043448

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Network Organisation and the Dynamics of Tubules in the Endoplasmic Reticulum

Autor: Hannah T. Perkins, Pierre Ducluzaux, Victoria J. Allan, Philip G. Woodman, Thomas A. Waigh

The endoplasmic reticulum (ER) is a eukaryotic subcellular organelle composed of tubules and sheet-like areas of membrane connected at junctions. The tubule network is highly dynamic and undergoes rapid and continual rearrangement. There are currentl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::554f9c6d29baa819ef862f804eff03ec
https://doi.org/10.1101/2020.03.11.987891

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Akademický článek

Roles of dynein and dynactin in early endosome dynamics revealed using automated tracking and global analysis.

Autor: Neftali Flores-Rodriguez, Salman S Rogers, David A Kenwright, Thomas A Waigh, Philip G Woodman, Victoria J Allan

Publikováno v: PLoS ONE, Vol 6, Iss 9, p e24479 (2011)

Microtubule-dependent movement is crucial for the spatial organization of endosomes in most eukaryotes, but as yet there has been no systematic analysis of how a particular microtubule motor contributes to early endosome dynamics. Here we tracked ear

Externí odkaz: https://doaj.org/article/d1a58c9827774e1aafa82d46a1f3c384

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ESCRT-III is necessary for the integrity of the nuclear envelope in micronuclei but is aberrant at ruptured micronuclear envelopes generating damage

Autor: Alexa J. Cleasby, Jessica Willan, Flavia Stefani, Helen E. Bryant, Cinzia Rinaldo, Philip G. Woodman, Barbara Ciani, Emma Grant, Alessandra Pisciottani, Neftali Flores-Rodriguez

Publikováno v: Oncogenesis
Oncogenesis, Vol 8, Iss 5, Pp 1-14 (2019)
Willan, J, Cleasby, A J, Flores-Rodriguez, N, Stefani, F, Rinaldo, C, Pisciottani, A, Grant, E, Woodman, P, Bryant, H E & Ciani, B 2019, ' ESCRT-III is necessary for the integrity of the nuclear envelope in micronuclei but is aberrant at ruptured micronuclear envelopes generating damage ', Oncogenesis, vol. 8, no. 5, 29 . https://doi.org/10.1038/s41389-019-0136-0
Oncogenesis 8 (2019). doi:10.1038/s41389-019-0136-0
info:cnr-pdr/source/autori:Willan, Jessica; Cleasby, Alexa J.; Flores-Rodriguez, Neftali; Stefani, Flavia; Rinaldo, Cinzia; Pisciottani, Alessandra; Grant, Emma; Woodman, Philip; Bryant, Helen E.; Ciani, Barbara/titolo:ESCRT-III is necessary for the integrity of the nuclear envelope in micronuclei but is aberrant at ruptured micronuclear envelopes generating damage/doi:10.1038%2Fs41389-019-0136-0/rivista:Oncogenesis/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume:8

Micronuclei represent the cellular attempt to compartmentalize DNA to maintain genomic integrity threatened by mitotic errors and genotoxic events. Some micronuclei show aberrant nuclear envelopes (NEs) that collapse, generating damaged DNA that can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8f2f1099dfc47ad7ead86b431fa4564
https://eprints.whiterose.ac.uk/145075/1/Willan_et_al-2019-Oncogenesis.pdf

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