Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Philip G. Knight"'
Autor:
Nicholas Hatzirodos, Claire Glister, Katja Hummitzsch, Helen F Irving-Rodgers, Philip G Knight, Raymond J Rodgers
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173391 (2017)
In vitro culture of ovarian granulosa cells and theca cells has been very important for our understanding of their function and regulation. One of the most eagerly sought attributes of cell culture is the use of chemically-defined conditions. However
Externí odkaz:
https://doaj.org/article/7a81cf85a02d4fc08aea8b2d0da53155
Modulatory effects of TGF-β1 and BMP6 on thecal angiogenesis and steroidogenesis in the bovine ovary
Publikováno v:
Reproduction. 159:397-408
Angiogenesis plays an integral role in follicular and luteal development and is positively regulated by several intra-ovarian factors including vascular endothelial growth factor A (VEGFA) and fibroblast growth factor 2 (FGF2). Various transforming g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::076aec204f4dffaf9d1d597a4e458a05
https://doi.org/10.1530/rep-19-0311
https://doi.org/10.1530/rep-19-0311
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49553 (2012)
Valproic acid (VPA) is used widely to treat epilepsy and bipolar disorder. Women undergoing VPA treatment reportedly have an increased incidence of polycystic ovarian syndrome (PCOS)-like symptoms including hyperandrogenism and oligo- or amenorrhoea.
Externí odkaz:
https://doaj.org/article/74528fcdda264cd8b6d0176c1b01ef06
Publikováno v:
Reproduction.
Myostatin plays a negative role in skeletal muscle growth regulation but its potential role in the ovary has received little attention. Here, we first examined relative expression of myostatin (MSTN), myostatin receptors (ACVR1B, ACVR2B and TGFBR1) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8959b728aa2e544ab6c165343d89598a
https://doi.org/10.1530/rep-18-0114
https://doi.org/10.1530/rep-18-0114
Pro-inflammatory cytokines secreted by macrophages and other cell types are implicated as intraovarian factors affecting different aspects of ovarian function including follicle and corpus luteum ‘turnover’, steroidogenesis and angiogenesis. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcf3ae3a6d64989728506df78eabe10f
Autor:
Philip G. Knight, Kee Heng, M. Yoshida, Ravinder Anand-Ivell, G.E. Hale, Kelton Tremellen, Richard Ivell, Yanzhenzi Dai
Publikováno v:
Human Reproduction. 28:3093-3102
Study question: How does insulin-like factor 3 (INSL3) concentration in blood vary across the menstrual cycle in women? Summary answer: INSL3 is secreted by the theca interna cells of growing antral follicles and is phasic in its expression. What is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e01cfe246a38aeb62bc5720a030e8555
https://doi.org/10.1093/humrep/det349
https://doi.org/10.1093/humrep/det349
Autor:
Carol Herkimer, Wen Ye, Vasantha Padmanabhan, David James Phillips, Philip G. Knight, Almudena Veiga-Lopez
Publikováno v:
Biology of Reproduction. 78:636-647
Prenatal testosterone excess leads to neuroendocrine, ovarian, and metabolic disruptions, culminating in reproductive phenotypes mimicking that of women with polycystic ovary syndrome (PCOS). The objective of this study was to determine the consequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea48e18f7c3c5c908a0195067f8ee86a
https://doi.org/10.1095/biolreprod.107.065904
https://doi.org/10.1095/biolreprod.107.065904
Publikováno v:
Reproduction. 133:1159-1168
Ovarian follicle development is regulated through endocrine and local mechanisms. Increasing evidence indicates roles for transforming growth factor β superfamily members, including inhibins and activins. We recently identified divergent expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a53d36c0e4be5c798cde755122db4db
https://doi.org/10.1530/rep-06-0179
https://doi.org/10.1530/rep-06-0179
Publikováno v:
Reproduction (Cambridge, England). 150(2)
Five isoforms of follistatin (FST) (Mr31, 33, 35, 37, and 41 kDa) were purified from bovine follicular fluid (bFF). Comparison of their activin and heparan sulphate proteoglycan (HSP) binding properties and biopotencies in the neutralisation of activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d12f00f1de3ac590cb5769e2fcc77093
https://pubmed.ncbi.nlm.nih.gov/25964381
https://pubmed.ncbi.nlm.nih.gov/25964381
Publikováno v:
Journal of Endocrinology. 188:215-225
The aim was to determine whether follicle growth in cattle is accompanied by changes in levels of inhibin-A (inh-A), activin-A (act-A) and different Mr isoforms of follistatin (FS) in bovine follicular fluid (bFF), reflecting differential roles of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d217f4a549001fe40cb8b916e6695de8
https://doi.org/10.1677/joe.1.06485
https://doi.org/10.1677/joe.1.06485