Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Philip G. Dunbar"'
1
Synthesis and Biological Characterization of 1,4,5,6-Tetrahydropyrimidine and 2-Amino-3,4,5,6-tetrahydropyridine Derivatives as Selective m1 Agonists
Autor: Sumudra Periyasamy, Sbeih S, Scott Roknich, Huzl Jj rd, Z. Fang, H. Zhang, M.A.N. Edgar, Y. Liu, Taikyun Rho, Peter I. Nagy, Dan O. Ngur, Y.F. Abuh, B. Ojo, Afif A. El-Assadi, Philip G. Dunbar, William S. Messer
Publikováno v: Journal of Medicinal Chemistry. 40:1230-1246
Previous studies identified several novel tetrahydropyrimidine derivatives exhibiting muscarinic agonist activity in rat brain. Such compounds might be useful in treating cognitive and memory deficits associated with low acetylcholine levels, as foun
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af5f2487172f847af283768e518fc847
https://doi.org/10.1021/jm960467d
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2
Design, synthesis, and neurochemical evaluation of 5-(3-alkyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists
Autor: Afif A. El-Assadi, Wayne Hoss, Dan O. Ngur, Philip G. Dunbar, Graham J. Durant, William S. Messer, Zheng Fang, Sumudra Periyasamy, Y.F. Abuh
Publikováno v: Journal of Medicinal Chemistry. 36:842-847
A series of 5-(3-alkyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines+ ++ (7a-h) was synthesized for biological evaluation as selective agonists for M1 receptors coupled to phosphoinositide (PI) metabolism in the central nervous system. Each lig
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02f67683c1b203cc094a90e8e8f2625c
https://doi.org/10.1021/jm00059a008
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3
Synthesis, biochemical activity and behavioral effects of a series of 1,4,5,6-tetrahydropyrimidines as novel ligands for M1 receptors
Autor: Sumudra Periyasamy, Wayne Hoss, William S. Messer, Dan O. Ngur, Brenda R. Ellerbrock, Taikyun Rho, Mark Bohnett, Kevin Ryan, Philip G. Dunbar, Graham J. Durant
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 2:781-786
A series of novel tetrahydropyrimidines was synthesized and examined for M 1 muscarinic receptor activity. 1,4,5,6-Tetrahydro-5-methoxycarbonyl-pyrimidine hydrobromide ( 1a ; CDD-0034-C) displayed a high affinity for muscarinic receptors in rat brain
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c70c17c526e9f8235867df4252fe2b1
https://doi.org/10.1016/s0960-894x(00)80531-4
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4
Stereoselective binding and activity of oxotremorine analogs at muscarinic receptors in rat brain
Autor: Philip G. Dunbar, Uli Hacksell, Shu-mei Ting, Björn Nilsson, Y.F. Abuh, Wayne Hoss, Dan O. Ngur, William S. Messer, Linda A. Dokas
Publikováno v: Chirality. 4:463-468
The activities of the enantiomers of BM-5 were examined to measure muscarinic cholinergic selectivity in the central nervous system. Autoradiographic studies assessed the ability of each enantiomer to inhibit the binding of [3H]-(R)-quinuclidinyl ben
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb502fc1546c7987cb6d9786ea703dac
https://doi.org/10.1002/chir.530040802
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