Výsledky vyhledávání - "Philip G. Szekeres"

Short Fibrils Constitute the Major Species of Seed-Competent Tau in the Brains of Mice Transgenic for Human P301S Tau

Autor: Samuel J. Jackson, Philip G. Szekeres, Caroline Kerridge, Claire V. Cella, Michel Goedert, Benjamin Falcon, Michael J. O'Neill, Zeshan Ahmed, Michael Hutton, Jane Cooper, Suchira Bose, Annalisa Cavallini, Alessia Landi, Tracey K. Murray

Publikováno v: The Journal of Neuroscience. 36:762-772

The interneuronal propagation of aggregated tau is believed to play an important role in the pathogenesis of human tauopathies. It requires the uptake of seed-competent tau into cells, seeding of soluble tau in recipient neurons and release of seeded

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bba8fa79f1a60acfb23635c4b745e525
https://doi.org/10.1523/jneurosci.3542-15.2016

Zobrazit plný text záznamu

An Unbiased Approach to Identifying Tau Kinases That Phosphorylate Tau at Sites Associated with Alzheimer Disease

Autor: Peter Davies, John N. Calley, Sarah Glover, Roger Moore, Amanda J. Bell, Suzanne C. Brewerton, Eric Karran, Annalisa Cavallini, Philip G. Szekeres, Michael Poidinger, Devaki Ramachandran, Clare Hardy, Michael Hutton, Suchira Bose, Samantha Sargent

Publikováno v: Journal of Biological Chemistry. 288:23331-23347

Neurofibrillary tangles, one of the hallmarks of Alzheimer disease (AD), are composed of paired helical filaments of abnormally hyperphosphorylated tau. The accumulation of these proteinaceous aggregates in AD correlates with synaptic loss and severi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4328d38f19e34dc88a7b7d6a434d84f9
https://doi.org/10.1074/jbc.m113.463984

Zobrazit plný text záznamu

Halting of caspase activity protects tau from MC1-conformational change and aggregation

Autor: Sarah Eversden, Lucy Hamilton, Dimitra Kestoras, Peter Davies, Sophie Jones, Philip G. Szekeres, Mike Hutton, Michael J. O'Neill, Ross Goodson, Emma Mead, Yolanda Gibson, Joanna Wolak

Publikováno v: Journal of Alzheimer's Disease

Intracellular neurofibrillary tangles (NFTs) are the hallmark of Alzheimer’s disease and other tauopathies in which tau, a microtubule-associated protein, loses its ability to stabilize microtubules. Several post-translational modifications includi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::519b966c85a0890934ac8cc732cb98c0
http://ora.ox.ac.uk/objects/uuid:

Zobrazit plný text záznamu

The Discovery of a Selective, Small Molecule Agonist for the Mas-Related Gene X1 Receptor

Autor: Alison I. Muir, William J. Coates, Adrian Hall, Stephen L. Garland, Neville Hubert Nicholson, Graham D Smith, Mark Wigglesworth, Shahzad Sharooq Rahman, Philip G. Szekeres, Berthold Wroblowski, Jag Paul Heer

Publikováno v: Journal of Medicinal Chemistry. 52:818-825

The novel 7-transmembrane receptor MrgX1 is located predominantly in the dorsal root ganglion and has consequently been implicated in the perception of pain. Here we describe the discovery and optimization of a small molecule agonist and initial dock

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db9be92b3706555ea9dc7c317d831fed
https://doi.org/10.1021/jm800962k

Zobrazit plný text záznamu

Development of Homogeneous 384-Well High-Throughput Screening Assays for Aβ1-40 and Aβ1-42 Using AlphaScreen™ Technology

Autor: Ann E. Kingston, Kaitlin Leong, Philip G. Szekeres, Theresa A. Day, Eric Karran

Publikováno v: SLAS Discovery. 13:101-111

Amyloid beta (Abeta) peptides are the major constituent of amyloid plaques, one of the hallmark pathologies of Alzheimer's disease. Accurate and precise quantitation of these peptides in biological fluids is a critical component of Alzheimer's diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94cafae4ddee2cd21f48a0ccd45f16ee
https://doi.org/10.1177/1087057107312778

Zobrazit plný text záznamu

Ligands selective for α4β2 but not α3β4 or α7 nicotinic receptors generalise to the nicotine discriminative stimulus in the rat

Autor: Adrian J. Mogg, Philip G. Szekeres, Elisiana Tafi, Ian A. Pullar, Mark D. Tricklebank, Janice W. Smith, Eleanor Peacey

Publikováno v: Psychopharmacology. 190:157-170

Nicotine produces behavioural effects that are potentially related to its interaction with diverse nicotinic acetylcholine receptor populations. Evidence from gene deletion studies suggests that the interoceptive stimulus properties of nicotine are m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::af5622737df89ff417c0aee9c750601b
https://doi.org/10.1007/s00213-006-0596-8

Zobrazit plný text záznamu

Signaling and Ligand Binding by Recombinant Neuromedin U Receptors: Evidence for Dual Coupling to Gαq/11 and Gαi and an Irreversible Ligand-Receptor Interaction

Autor: Philip G. Szekeres, Alan Wise, Paul J. Brighton, Gary B. Willars

Publikováno v: Molecular Pharmacology. 66:1544-1556

The neuropeptide neuromedin U (NmU) shows considerable structural conservation across species. Within the body, it is widely distributed and in mammals has been implicated in physiological roles, including the regulation of feeding, anxiety, pain, bl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed436f4545c8c571c31d7ed63512d73d
https://doi.org/10.1124/mol.104.002337

Zobrazit plný text záznamu

GPR105, a novel Gi/o-coupled UDP-glucose receptor expressed on brain glia and peripheral immune cells, is regulated by immunologic challenge: possible role in neuroimmune function

Autor: Shelagh Wilson, Richard L.M. Faull, Philip G. Szekeres, Jeannette M. Watson, Paul R. Murdock, Henry J. Waldvogel, Darren J. Moore, Katie Freeman, Piers C. Emson

Publikováno v: Molecular Brain Research. 118:10-23

We have recently shown that UDP-glucose, and some related UDP-sugars, are potent agonists of the novel G protein-coupled receptor GPR105 (recently re-named P2Y(14)). GPR105 is widely expressed throughout many brain regions and peripheral tissues of h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c596109aa1da06ae59085ff7a8e7bf83
https://doi.org/10.1016/s0169-328x(03)00330-9

Zobrazit plný text záznamu

Involvement of Receptor Cycling and Receptor Reserve in Resensitization of Muscarinic Responses in SH-SY5Y Human Neuroblastoma Cells

Autor: Philip G. Szekeres, J. M. Edwardson, Jennifer A. Koenig

Publikováno v: Journal of Neurochemistry. 70:1694-1703

Preexposure of SH-SY5Y cells to the muscarinic agonist carbachol caused a rapid desensitization of subsequent carbachol-stimulated intracellular Ca2+ responses and a slower decrease in the number of receptors at the plasma membrane. Desensitization (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7e4cc9dbbac3974f14ea376d72069e5
https://doi.org/10.1046/j.1471-4159.1998.70041694.x

Zobrazit plný text záznamu

Functional Assays for Identifying Ligands at Orphan G Protein-Coupled Receptors

Autor: Philip G. Szekeres

Publikováno v: Receptors and Channels. 8:297-308

The superfamily of G protein-coupled receptors (GPCRs; 7TMs) is one of the largest families of genes identified in humans, and has a proven history of being an excellent source of drug targets. The near completion of the human genome sequencing proje

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a6e41c5ba5d6a19100912ce7054e1dcb
https://doi.org/10.3109/10606820214642

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání