Zobrazeno 1 - 10
of 299
pro vyhledávání: '"Philip G Board"'
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162415 (2016)
The cardiac ryanodine receptor (RyR2) is an intracellular ion channel that regulates Ca2+ release from the sarcoplasmic reticulum (SR) during excitation-contraction coupling in the heart. The glutathione transferases (GSTs) are a family of phase II d
Externí odkaz:
https://doaj.org/article/6ed2d91727c74af68a1447490b4726f5
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60324 (2013)
Glutathione transferases (GSTs) are dimeric enzymes containing one active-site per monomer. The omega-class GSTs (hGSTO1-1 and hGSTO2-2 in humans) are homodimeric and carry out a range of reactions including the glutathione-dependant reduction of a r
Externí odkaz:
https://doaj.org/article/1e81778efc344752af6c13c8ddd1ebd2
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17864 (2011)
It has recently emerged that glutathione transferase enzymes (GSTs) and other structurally related molecules can be translocated from the external medium into many different cell types. In this study we aim to explore in detail, the structural featur
Externí odkaz:
https://doaj.org/article/059762a195524142b4550b254e947e8f
Autor:
Alex Perálvarez-Marín, Hanshen Tae, Philip G Board, Marco G Casarotto, Angela F Dulhunty, Montserrat Samsó
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25813 (2011)
The type 1 skeletal muscle ryanodine receptor (RyR1) is principally responsible for Ca(2+) release from the sarcoplasmic reticulum and for the subsequent muscle contraction. The RyR1 contains three SPRY domains. SPRY domains are generally known to me
Externí odkaz:
https://doaj.org/article/104ae59be1d54bedb1b53b418169fa2a
Autor:
Mark M. Hughes, Nilisha Fernando, Shuhei Takahashi, Padmaja Tummala, Melissa Rooke, Marco G. Casarotto, Jane E. Dahlstrom, Philip G. Board, Luke A. J. O'Neill
Publikováno v:
Carcinogenesis. 42:853-863
Inflammatory bowel disease (IBD) is characterized by multiple alterations in cytokine expression and is a risk factor for colon cancer. The Omega class glutathione transferase GSTO1-1 regulates the release of the pro-inflammatory cytokines interleuki
Autor:
Danny Rangasamy, P.-T. Chiou, Stephen J. Ohms, Marco G. Casarotto, Jane E. Dahlstrom, Philip G. Board
Publikováno v:
Clinical and Translational Oncology. 23:353-363
In contrast to hormone receptor driven breast cancer, patients presenting with triple-negative breast cancer (TNBC) often have limited drug treatment options. Efavirenz, a non-nucleoside reverse transcriptase (RT) inhibitor targets abnormally overexp
Autor:
Takeshi Yuasa, Kosuke Takemura, Gulanbar Amori, Philip G. Board, Kentaro Inamura, Junji Yonese, Fumitaka Koga
Publikováno v:
Targeted Oncology. 15:347-356
γ-Glutamyltransferase (GGT) is a marker of oxidative stress. Elevated serum GGT is linked to poor survival in various malignancies; however, there are no data on metastatic renal cell carcinoma (mRCC). Additionally, GGT expression in cancer tissues
Autor:
Leon A. Sokulsky, Simon Keely, Philip G. Board, Paul S. Foster, Ming Yang, Simonne Sherwin, Gerard E. Kaiko, Fiona Eyers, Bridie J. Goggins
Publikováno v:
Clinical & Experimental Allergy. 50:609-624
BACKGROUND Glutathione S-transferases omega class 1 (GSTO1-1) is a unique member of the GST family regulating cellular redox metabolism and innate immunity through the promotion of LPS/TLR4/NLRP3 signalling in macrophages. House dust mite (HDM) trigg
Autor:
Girdhar Singh Deora, Aaron J. Oakley, Philip G. Board, Yuji Nakano, Jayme L. Dahlin, Padmaja Tummala, Jonathan B. Baell, Jessica M. Strasser, Yiyue Xie, Michael A. Walters, Melissa Rooke, Matthew E. Cuellar, Marco G. Casarotto
Publikováno v:
Journal of Medicinal Chemistry. 63:2894-2914
Glutathione transferase omega-1 (GSTO1-1) is an enzyme whose function supports the activation of interleukin (IL)-1β and IL-18 that are implicated in a variety of inflammatory disease states for which small-molecule inhibitors are sought. The potent
Autor:
Pey-Tsyr Chiou, Stephen Ohms, Philip G. Board, Jane E. Dahlstrom, Danny Rangasamy, Marco G. Casarotto
Publikováno v:
Cancers; Volume 13; Issue 24; Pages: 6232
Cancers, Vol 13, Iss 6232, p 6232 (2021)
Cancers
Cancers, Vol 13, Iss 6232, p 6232 (2021)
Cancers
Simple Summary Cancer stem cells (CSCs) are responsible for tumour initiation, chemo- and radiotherapy resistance and cancer recurrence. CSCs display plasticity that enables them to alter their phenotype and function making them challenging to elimin