Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Philip G, Kasprzyk"'
Autor:
Neil A. Schwarz, Matthew T. Stratton, Ryan J. Colquhoun, Alexia M. Manganti, Margaux Sherbourne, Florian Mourey, Caitlyn C. White, Heather Day, Micaela C. Dusseault, Geoffrey M. Hudson, Christopher R. Vickery, Holly C. Schachner, Philip G. Kasprzyk, Jing-Ke Weng
Publikováno v:
Journal of the International Society of Sports Nutrition, Vol 21, Iss 1 (2024)
Background Rhodiola rosea extract is purported to improve physical performance and support resilience to stress. Salidroside is considered to be one of the main constituents responsible for the ergogenic actions of R. rosea. However, R. rosea extract
Externí odkaz:
https://doaj.org/article/d2823e133d26493caef30f6c949c442a
Autor:
Philip G. Kasprzyk, Christopher Vickery, Mingli Ye, Magdalena Sewastianik, Wei Gong, Sheng Ding, Margitta Dziwenka, Amy Mozingo, Kaiti Valm, Holly Schachner, Jing-Ke Weng
Publikováno v:
Nutrients; Volume 14; Issue 11; Pages: 2330
Bioactive phytochemicals such as salidroside have been studied to understand the beneficial effects of Rhodiola rosea, an herbaceous plant used in traditional medicine to increase energy and treat a variety of health issues. However, Rhodiola plants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5e01044804da4fca2feb1635594ff8e
https://pubmed.ncbi.nlm.nih.gov/35684130
https://pubmed.ncbi.nlm.nih.gov/35684130
Autor:
Florence Meyer-Losic, Simon P Newman, Joanna M Day, Michael J Reed, Philip G Kasprzyk, Atul Purohit, Paul A Foster
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e80305 (2013)
Despite paclitxael's clinical success, treating hormone-refractory breast cancer remains challenging. Paclitaxel has a poor pharmacological profile, characterized by a low therapeutic index (TIX) caused by severe dose limiting toxicities, such as neu
Externí odkaz:
https://doaj.org/article/72fc20d8905647e1aed52f755a02a4f3
Autor:
Ernest Hamel, Pascoe Mannion, Grégory Menchon, Mathew P. Leese, Michel O. Steinmetz, Philip G. Kasprzyk, Mark P. Thomas, Eric Ferrandis, Barry V. L. Potter, Fabrice Jourdan, Paul A. Foster, Andrea E. Prota, Wolfgang Dohle
Publikováno v:
Journal of Medicinal Chemistry. 61:1031-1044
Quinazolinone-based anti-cancer agents were designed, decorated with functional groups from a 2-methoxyestradiol-based microtubule disruptor series, incorporating the aryl sulfamate motif of steroid sulfatase (STS) inhibitors. The steroidal AB-ring s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66a2cfd9fa7b18e19c31a4bfb1e2c49f
https://doi.org/10.1021/acs.jmedchem.7b01474
https://doi.org/10.1021/acs.jmedchem.7b01474
Autor:
Ernest Hamel, Ann Fiore, Simon P. Newman, Ruoli Bai, Mathew P. Leese, Meriel R. Major, Fabrice Jourdan, Philip G. Kasprzyk, Wolfgang Dohle, Eric Ferrandis, Atul Purohit, Barry V. L. Potter
Publikováno v:
ChemMedChem. 9:350-370
The syntheses and antiproliferative activities of novel substituted tetrahydroisoquinoline derivatives and their sulfamates are discussed. Biasing of conformational populations through substitution on the tetrahydroisoquinoline core at C1 and C3 has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4704a75c99b657f197a8b9002766f84c
https://doi.org/10.1002/cmdc.201300412
https://doi.org/10.1002/cmdc.201300412
Autor:
Dennis Bigg, Simon P. Newman, Chloe Stengel, Sonia Bernetiere, Raphael Dellile, Mark Carlson, José Camara, Eric Ferrandis, Mélissa Le Moing, Nadine Narboux, Vincent Hesry, Delphine Morlais, Olivier Dutruel, Dominique Pons, Pierrick Auvray, Anne-Marie Liberatore, Philip G. Kasprzyk, Hélène Coulomb, Ann Savola Nelson, Béatrice Foll, Gregoire Prevost
Publikováno v:
Molecular Cancer Therapeutics. 7:2426-2434
Tubulin is a validated target for antitumor drugs. However, the effectiveness of these microtubule-interacting agents is limited by the fact that they are substrates for drug efflux pumps (P-glycoprotein) and/or by the acquisition of point mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1e8e70f3246309738f21d393b63bf5b
https://doi.org/10.1158/1535-7163.mct-08-0208
https://doi.org/10.1158/1535-7163.mct-08-0208
Autor:
Paul A. Foster, Simon P. Newman, Joanna M. Day, Bindumalini Raobaikady, Michael J. Reed, Y T Ho, Barry V. L. Potter, M P Leese, Philip G. Kasprzyk, A. Purohit
Publikováno v:
British Journal of Cancer
Therapies for hormone-independent prostate and breast cancer are limited, with the effectiveness of the taxanes compromised by toxicity, lack of oral bioavailability and drug resistance. This study aims to identify and characterise new microtubule di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb17d58f914856b2c9f6aa8749bec6e9
http://europepmc.org/articles/PMC2360283
http://europepmc.org/articles/PMC2360283
Autor:
Atul Purohit, Paul A. Foster, Simon P. Newman, Y T Ho, Mathew P. Leese, Philip G. Kasprzyk, Barry V. L. Potter, Michael J. Reed
Publikováno v:
Breast Cancer Research and Treatment. 111:251-260
Breast cancer is the leading cause of cancer deaths among women worldwide. The theory of targeting both cancer cells directly and their blood supply has significant therapeutic potential. However, to date, there are few clinically successful single a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::437da25a3d735adcb00e42a90dc5b2bb
https://doi.org/10.1007/s10549-007-9791-5
https://doi.org/10.1007/s10549-007-9791-5
Autor:
Gregoire Prevost, Pierre Roubert, Daniel W. Zaharevitz, Marie Odile Lonchampt, Samir Attoub, Sophie Chaumeron, Mike Alley, Erik Bruyneel, Hélène Coulomb, Ann Savola, Philip G. Kasprzyk, Susan Holbeck, John Wright, Quang-Dé Nguyen, Patricia Forgez, Christian Gespach, Marie C. Brezak, Mark Bracke, Eric Ferrandis, Marion Huchet, Danièle Demarquay
Publikováno v:
Cancer Research. 66:9227-9234
A large number of hormones and local agonists activating guanine-binding protein-coupled receptors (GPCR) play a major role in cancer progression. Here, we characterize the new imidazo-pyrazine derivative BIM-46174, which acts as a selective inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e35e09855de720491c38a3f5fd371a5
https://doi.org/10.1158/0008-5472.can-05-4205
https://doi.org/10.1158/0008-5472.can-05-4205
Autor:
Dennis Bigg, José Camara, Laurence Lesueur-Ginot, Hélène Coulomb, Philip G. Kasprzyk, Danièle Demarquay, Marion Huchet, Olivier Lavergne, Gregoire Prevost
Publikováno v:
Cancer Research. 64:4942-4949
BN80927 belongs to a novel family of camptothecin analogs, the homocamptothecins, developed on the concept of topoisomerase I (Topo I) inhibition and characterized by a stable seven-membered β-hydroxylactone ring. Preclinical data reported here show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::503adab5a27c3987410b3a0e91a21700
https://doi.org/10.1158/0008-5472.can-03-3872
https://doi.org/10.1158/0008-5472.can-03-3872