Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Philip Eckert"'
Autor:
Michael G. Organ, Philip Eckert
Publikováno v:
Chemistry – A European Journal. 26:4861-4865
The role that LiBr plays in the lifetime of Pd-NHC complexes has been investigated. A bromide ion is proposed to coordinate to Pd thereby preventing beta hydride elimination (BHE) (to form NHC-H+ ) of the reductive elimination (RE) intermediate that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b5e3d95d9e61737e8d602204fea8d3
https://doi.org/10.1002/chem.202000288
https://doi.org/10.1002/chem.202000288
Autor:
Philip Eckert, Michael G. Organ
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 28(35)
Bulky Pd-N-heterocyclic carbene (NHC) catalysts (e. g., N-(di-2,6-(3-pentyl)phenyl), IPent) have been shown to have significantly higher reactivity in a wide variety of cross-coupling applications (i. e., C-C, C-S, C-N) than less hindered variants (e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de3aea18d52c97ab2b0adf6c3119311
https://pubmed.ncbi.nlm.nih.gov/35470486
https://pubmed.ncbi.nlm.nih.gov/35470486
Autor:
Philip Eckert, Martin J. McGavin, José Carlos Bozelli, Robert C. Kuiack, Ronald S. Flannagan, Tomasz L. Czarny, Omar M. El-Halfawy, David E. Heinrichs, Eric D. Brown, Richard M. Epand, Michael G. Organ, Ahmed Salim, Jonathan Day
Publikováno v:
Nature Chemical Biology. 16:143-149
Staphylococcus aureus is the leading cause of infections worldwide, and methicillin-resistant strains (MRSA) are emerging. New strategies are urgently needed to overcome this threat. Using a cell-based screen of ~45,000 diverse synthetic compounds, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::559cb3807263b9482940202ade9c2120
https://doi.org/10.1038/s41589-019-0401-8
https://doi.org/10.1038/s41589-019-0401-8
Autor:
Philip Eckert, Michael G. Organ
Publikováno v:
Chemistry – A European Journal. 25:15751-15754
The impact of LiBr and ZnBr2 salts on the Negishi coupling of alkylZnBr and dialkylzinc nucleophiles with both electron-rich and -poor aryl electrophiles has been examined. Focusing only on the more difficult coupling of deactivated (electron-rich) o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fefae0174e7ede313c5da62ad7c05979
https://doi.org/10.1002/chem.201903931
https://doi.org/10.1002/chem.201903931
Publikováno v:
Angewandte Chemie (International ed. in English). 60(22)
The first cross-coupling of organozinc nucleophiles with aryl halides was reported in 1977 by Negishi. Unknown to all at the time was the importance of salt additives that were often present as a byproduct from the organozinc preparation. For decades
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25962ffd26dbcc06b44897f08b62e9bf
https://pubmed.ncbi.nlm.nih.gov/32986262
https://pubmed.ncbi.nlm.nih.gov/32986262
Autor:
Philip, Eckert, Michael G, Organ
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 25(69)
The impact of LiBr and ZnBr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d957c1ff3deb8b98e3878b667f65e2c6
https://pubmed.ncbi.nlm.nih.gov/31544269
https://pubmed.ncbi.nlm.nih.gov/31544269
Autor:
Omar M, El-Halfawy, Tomasz L, Czarny, Ronald S, Flannagan, Jonathan, Day, José Carlos, Bozelli, Robert C, Kuiack, Ahmed, Salim, Philip, Eckert, Richard M, Epand, Martin J, McGavin, Michael G, Organ, David E, Heinrichs, Eric D, Brown
Publikováno v:
Nature chemical biology. 16(2)
Staphylococcus aureus is the leading cause of infections worldwide, and methicillin-resistant strains (MRSA) are emerging. New strategies are urgently needed to overcome this threat. Using a cell-based screen of ~45,000 diverse synthetic compounds, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c12d97bee01941c750267164956e52ae
https://pubmed.ncbi.nlm.nih.gov/31797908
https://pubmed.ncbi.nlm.nih.gov/31797908