Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Philip E. Stuart"'
Autor:
Philip E. Stuart, Lam C. Tsoi, Rajan P. Nair, Manju Ghosh, Madhulika Kabra, Pakeeza A. Shaiq, Ghazala K. Raja, Raheel Qamar, B.K. Thelma, Matthew T. Patrick, Anita Parihar, Sonam Singh, Sujay Khandpur, Uma Kumar, Michael Wittig, Frauke Degenhardt, Trilokraj Tejasvi, John J. Voorhees, Stephan Weidinger, Andre Franke, Goncalo R. Abecasis, Vinod K. Sharma, James T. Elder
Publikováno v:
HGG Advances, Vol 3, Iss 1, Pp 100069- (2022)
Summary: Because transethnic analysis may facilitate prioritization of causal genetic variants, we performed a genome-wide association study (GWAS) of psoriasis in South Asians (SAS), consisting of 2,590 cases and 1,720 controls. Comparison with our
Externí odkaz:
https://doaj.org/article/5428a1ebeaa24b259fb5e47d9912fd38
Autor:
Matthew T. Patrick, Philip E. Stuart, Kalpana Raja, Johann E. Gudjonsson, Trilokraj Tejasvi, Jingjing Yang, Vinod Chandran, Sayantan Das, Kristina Callis-Duffin, Eva Ellinghaus, Charlotta Enerbäck, Tõnu Esko, Andre Franke, Hyun M. Kang, Gerald G. Krueger, Henry W. Lim, Proton Rahman, Cheryl F. Rosen, Stephan Weidinger, Michael Weichenthal, Xiaoquan Wen, John J. Voorhees, Gonçalo R. Abecasis, Dafna D. Gladman, Rajan P. Nair, James T. Elder, Lam C. Tsoi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Approximately 30% of psoriasis patients develop psoriatic arthritis (PsA) and early diagnosis is crucial for the management of PsA. Here, Patrick et al. develop a computational pipeline involving statistical and machine-learning methods that can asse
Externí odkaz:
https://doaj.org/article/f67954f1b8fa41a1be488a5ddddc158b
Autor:
Nehal N. Mehta, Heather L. Teague, William R. Swindell, Yvonne Baumer, Nicole L. Ward, Xianying Xing, Brooke Baugous, Andrew Johnston, Aditya A. Joshi, Joanna Silverman, Drew H. Barnes, Liza Wolterink, Rajan P. Nair, Philip E. Stuart, Martin Playford, John J. Voorhees, Mrinal K. Sarkar, James T. Elder, Katherine Gallagher, Santhi K. Ganesh, Johann E. Gudjonsson
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Chronic inflammation is a critical component of atherogenesis, however, reliable human translational models aimed at characterizing these mechanisms are lacking. Psoriasis, a chronic inflammatory skin disease associated with increased suscep
Externí odkaz:
https://doaj.org/article/2fc891577ed8496cab73a2b9d95b1c7b
Autor:
Lam C. Tsoi, Philip E. Stuart, Chao Tian, Johann E. Gudjonsson, Sayantan Das, Matthew Zawistowski, Eva Ellinghaus, Jonathan N. Barker, Vinod Chandran, Nick Dand, Kristina Callis Duffin, Charlotta Enerbäck, Tõnu Esko, Andre Franke, Dafna D. Gladman, Per Hoffmann, Külli Kingo, Sulev Kõks, Gerald G. Krueger, Henry W. Lim, Andres Metspalu, Ulrich Mrowietz, Sören Mucha, Proton Rahman, Andre Reis, Trilokraj Tejasvi, Richard Trembath, John J. Voorhees, Stephan Weidinger, Michael Weichenthal, Xiaoquan Wen, Nicholas Eriksson, Hyun M. Kang, David A. Hinds, Rajan P. Nair, Gonçalo R. Abecasis, James T Elder
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Psoriasis is an immune-mediated skin disease with a complex genetic architecture. Here, Elder and colleagues identify 16 novel psoriasis susceptibility loci using GWAS meta-analysis with a combined effective sample size of over 39,000 individuals.
Externí odkaz:
https://doaj.org/article/f7c9d14db1d44c6a865877ade1d17933
Autor:
Matthew T. Patrick, Philip E. Stuart, Kalpana Raja, Sunyi Chi, Zhi He, John J. Voorhees, Trilokraj Tejasvi, Johann E. Gudjonsson, J. Michelle Kahlenberg, Vinod Chandran, Proton Rahman, Dafna D. Gladman, Rajan P. Nair, James T. Elder, Lam C. Tsoi
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
We recently conducted a large association analysis to compare the genetic profiles between patients with psoriatic arthritis (PsA) and cutaneous-only psoriasis (PsC). Despite including over 7,000 genotyped patients, only the MHC achieved genome-wide
Externí odkaz:
https://doaj.org/article/80b4cbc08a6c4994af9ada4abecb3beb
Autor:
Susan Martin, Jessica Tyrrell, E Louise Thomas, Matthew J Bown, Andrew R Wood, Robin N Beaumont, Lam C Tsoi, Philip E Stuart, James T Elder, Philip Law, Richard Houlston, Christopher Kabrhel, Nikos Papadimitriou, Marc Gunter, Caroline Bull, Joshua A Bell, Emma E Vincent, Naveed Sattar, Malcolm G Dunlop, Ian PM Tomlinson, Sara Lindström, INVENT consortium, Jimmy D Bell, Timothy Frayling, Hanieh Yaghootkar
Publikováno v:
eLife, Vol 11 (2022)
Externí odkaz:
https://doaj.org/article/40b858df13344706935722cd933d8d45
Autor:
Susan Martin, Jessica Tyrrell, E Louise Thomas, Matthew J Bown, Andrew R Wood, Robin N Beaumont, Lam C Tsoi, Philip E Stuart, James T Elder, Philip Law, Richard Houlston, Christopher Kabrhel, Nikos Papadimitriou, Marc J Gunter, Caroline J Bull, Joshua A Bell, Emma E Vincent, Naveed Sattar, Malcolm G Dunlop, Ian PM Tomlinson, Sara Lindström, INVENT consortium, Jimmy D Bell, Timothy M Frayling, Hanieh Yaghootkar
Publikováno v:
eLife, Vol 11 (2022)
Background: Some individuals living with obesity may be relatively metabolically healthy, whilst others suffer from multiple conditions that may be linked to adverse metabolic effects or other factors. The extent to which the adverse metabolic compon
Externí odkaz:
https://doaj.org/article/6ad55c6d14b64beb84bf87baac62a5be
Autor:
Matthew T. Patrick, Rajan P. Nair, Kevin He, Philip E. Stuart, Allison C. Billi, Xiang Zhou, Johann E. Gudjonsson, Jorge R. Oksenberg, James T. Elder, Lam C. Tsoi
Publikováno v:
Annals of Neurology.
Autor:
Kotaro Ogawa, Lam C. Tsoi, Hiroaki Tanaka, Masahiro Kanai, Philip E. Stuart, Rajan P. Nair, Yoshiya Tanaka, Hideki Mochizuki, James T. Elder, Yukinori Okada
Publikováno v:
Journal of Investigative Dermatology.
Autor:
Nehal N. Mehta, Philip E. Stuart, Johann E. Gudjonsson, Qingyuan Zhao, H. Zhang, Rajan P. Nair, James T. Elder, Kevin He, Xu-jie Zhou, Dajiang J. Liu, Samuel K. Handelman, John J. Voorhees, Lam C. Tsoi, Xianyong Yin, Matthew Patrick, Michael Boehnke
Publikováno v:
J Invest Dermatol
Psoriasis and type 2 diabetes (T2D) are complex conditions with significant impact on health. Psoriasis patients have higher risk of type 2 diabetes (~1.5 Odds Ratio) and vice versa, controlling for body mass index (BMI), yet there has been limited s