Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Philip E. Sanderson"'
Autor:
Eleanor Williams, Jana Bagarova, Georgina Kerr, Dong-Dong Xia, Elsie S. Place, Devaveena Dey, Yue Shen, Geoffrey A. Bocobo, Agustin H. Mohedas, Xiuli Huang, Philip E. Sanderson, Arthur Lee, Wei Zheng, Aris N. Economides, James C. Smith, Paul B. Yu, Alex N. Bullock
Publikováno v:
JCI Insight, Vol 6, Iss 8 (2021)
Currently, no effective therapies exist for fibrodysplasia ossificans progressiva (FOP), a rare congenital syndrome in which heterotopic bone is formed in soft tissues owing to dysregulated activity of the bone morphogenetic protein (BMP) receptor ki
Externí odkaz:
https://doaj.org/article/7588ba5cc1df479b9057715913b8a478
Autor:
Jonathan H. Shrimp, John Janiszewski, Catherine Z. Chen, Miao Xu, Kelli M. Wilson, Stephen C. Kales, Philip E. Sanderson, Paul Shinn, Rick Schneider, Zina Itkin, Hui Guo, Min Shen, Carleen Klumpp-Thomas, Samuel G. Michael, Wei Zheng, Anton Simeonov, Matthew D. Hall
Publikováno v:
ACS Infectious Diseases. 8:1191-1203
SARS-CoV-2 is the causative viral pathogen driving the COVID-19 pandemic that prompted an immediate global response to the development of vaccines and antiviral therapeutics. For antiviral therapeutics, drug repurposing allows for rapid movement of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a8a90490d5fba8e9777010836233a0
https://doi.org/10.1021/acsinfecdis.2c00172
https://doi.org/10.1021/acsinfecdis.2c00172
Autor:
Wei Sun, Rebecca A Weingarten, Miao Xu, Noel Southall, Sheng Dai, Paul Shinn, Philip E Sanderson, Peter R Williamson, Karen M Frank, Wei Zheng
Publikováno v:
Emerging Microbes and Infections, Vol 5, Iss 1, Pp 1-11 (2016)
Current antimicrobial susceptibility testing has limited screening capability for identifying empirical antibiotic combinations to treat severe bacterial infections with multidrug-resistant (MDR) organisms. We developed a new antimicrobial susceptibi
Externí odkaz:
https://doaj.org/article/5f0e5adc85714331a24883cfd820e076
Autor:
Wei Zheng, Richard J. Sciotti, Thoai Dotrang, Diana Caridha, Peter D. Ziniel, Kim C. Williamson, Xiao Lu, Emma Hughes, Hao Li, Xin Xu, Sandra Mendoza Guerrero, Gregory J. Tawa, Nita Gombakomba, Paul D. Roepe, Matthew D. Wilkerson, Anna R. Sternberg, Clifton L. Dalgard, Daniel Y. Bargieri, Daniel Hupalo, Karthik Krishnan, Xiuli Huang, Philip E. Sanderson, Wenwei Huang, Amy Wang, Wei Sun
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Drug resistance is a constant threat to malaria control efforts making it important to maintain a good pipeline of new drug candidates. Of particular need are compounds that also block transmission...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::817cce11babf696cecf28d09aa804a9e
https://doi.org/10.1021/acsptsci.0c00078
https://doi.org/10.1021/acsptsci.0c00078
Autor:
Jonathan H. Shrimp, John Janiszewski, Catherine Z. Chen, Miao Xu, Kelli M. Wilson, Stephen C. Kales, Philip E. Sanderson, Paul Shinn, Zina Itkin, Hui Guo, Min Shen, Carleen Klumpp-Thomas, Samuel G. Michael, Wei Zheng, Anton Simeonov, Matthew D. Hall
Publikováno v:
bioRxiv : the preprint server for biology.
SARS-CoV-2 is the causative viral pathogen driving the COVID-19 pandemic that prompted an immediate global response to the development of vaccines and antiviral therapeutics. For antiviral therapeutics, drug repurposing allowed for rapid movement of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3a3496a8bf0ee4283d868c2808c8157
https://pubmed.ncbi.nlm.nih.gov/35648838
https://pubmed.ncbi.nlm.nih.gov/35648838
Autor:
Karthik, Krishnan, Peter, Ziniel, Hao, Li, Xiuli, Huang, Daniel, Hupalo, Nita, Gombakomba, Sandra Mendoza, Guerrero, Thoai, Dotrang, Xiao, Lu, Diana, Caridha, Anna R, Sternberg, Emma, Hughes, Wei, Sun, Daniel Y, Bargieri, Paul D, Roepe, Richard J, Sciotti, Matthew D, Wilkerson, Clifton L, Dalgard, Gregory J, Tawa, Amy Q, Wang, Xin, Xu, Wei, Zheng, Philip E, Sanderson, Wenwei, Huang, Kim C, Williamson
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Drug resistance is a constant threat to malaria control efforts making it important to maintain a good pipeline of new drug candidates. Of particular need are compounds that also block transmission by targeting sexual stage parasite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c49bfb55c8f09de5ed3a3786b2ab8e30
https://pubmed.ncbi.nlm.nih.gov/33073193
https://pubmed.ncbi.nlm.nih.gov/33073193
Autor:
Philip E. Sanderson, Anton Simeonov, Jonathan H. Shrimp, Matthew D. Hall, Stephen C. Kales, Min Shen
Publikováno v:
ACS Pharmacology & Translational Science
bioRxiv
article-version (status) pre
article-version (number) 1
bioRxiv
article-version (status) pre
article-version (number) 1
SARS-CoV-2 is the viral pathogen causing the COVID19 global pandemic. Consequently, much research has gone into the development of pre-clinical assays for the discovery of new or repurposing of FDA-approved therapies. Preventing viral entry into a ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8565595fab250a7e416f44960174da4d
https://pubmed.ncbi.nlm.nih.gov/33062952
https://pubmed.ncbi.nlm.nih.gov/33062952
Autor:
Wei Zheng, Xiuli Huang, Philip E. Sanderson, Gregory J. Tawa, Gregory D. Cuny, Wenwei Huang, Khalida Shamim, Arthur Lee, Paul B. Yu, Xin Xu, Amy Wang, Kimloan Nguyen, Paresma R. Patel, Jian-kang Jiang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3356-3362
The pyrazolo[1,5-a]pyrimidine LDN-193189 is a potent inhibitor of activin receptor-like kinase 2 (ALK2) but is nonselective for highly homologous ALK3 and shows only modest kinome selectivity. Herein, we describe the discovery of a novel series of po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::595e481cd15da6decf8d72951652091b
https://doi.org/10.1016/j.bmcl.2018.09.006
https://doi.org/10.1016/j.bmcl.2018.09.006
Autor:
John C. McKew, Anton Simeonov, Myunghoon Kim, Wei Zheng, Kim C. Williamson, Takeshi Tanaka, Hao Li, Xiao Lu, Wenwei Huang, Richard M. Fisher, Xiuli Huang, Meghan J. Orr, Philip E. Sanderson, Wei Sun, Paresma R. Patel
Publikováno v:
ACS Combinatorial Science. 19:748-754
A novel three-component, two-step, one-pot nucleophilic aromatic substitution (SNAr)–intramolecular cyclization–Suzuki coupling reaction was developed for the synthesis of benzo[h][1,6]naphthyridin-2(1H)-ones (Torins). On the basis of the new eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b358308f0c9ee96efdda54b40709ba
https://doi.org/10.1021/acscombsci.7b00119
https://doi.org/10.1021/acscombsci.7b00119
Autor:
Paul Shinn, Wei Sun, Miao Xu, Xiangguo Qiu, Gregory J. Tawa, Carles Martínez-Romero, Shu Yang, Ethan G. Fisher, Philip E. Sanderson, Omid Motabar, Yan Long, Wei Zheng, Shihua He, Jennifer Kouznetsova, Peter R. Williamson, Adolfo García-Sastre
Publikováno v:
Antiviral Research. 137:165-172
Although a group of FDA-approved drugs were previously identified with activity against Ebola virus (EBOV), most of them are not clinically useful because their human blood concentrations are not high enough to inhibit EBOV infection. We screened 795
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91829f4a9b36e64831c01d150d9e1d2d
https://doi.org/10.1016/j.antiviral.2016.11.017
https://doi.org/10.1016/j.antiviral.2016.11.017