Výsledky vyhledávání - "Philip E. Mirkes"

The roles of p53 and p21 in normal development and hyperthermia-induced malformations

Autor: Gail S. Martin, Liezl E. Francisco, Hiromi Hosako, Philip E. Mirkes

Publikováno v: Birth Defects Research Part B: Developmental and Reproductive Toxicology. 86:40-47

BACKGROUND: Hyperthermia (HS) is a well-studied teratogen that induces serious malformations, including neural tube defects. Our previous studies have shown that HS induces apoptosis by activating the mitochondrial apoptotic pathway. Prior to activat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beca84064014a9882134944ca1411df2
https://doi.org/10.1002/bdrb.20180

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Cell death in normal and abnormal development

Autor: Philip E. Mirkes

Publikováno v: Congenital Anomalies. 48:7-17

Research over the past 50 years has consistently documented that cell death is an integral part of both normal development and the etiology of birth defects; however, the significance of this cell death has been, until recently, unclear. Research pub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::04b8daa983a1b3a991025a6834a7761d
https://doi.org/10.1111/j.1741-4520.2007.00175.x

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Teratogen-Induced Activation of p53 in Early Postimplantation Mouse Embryos

Autor: Sally A. Little, Marianne Barrier, Hiromi Hosako, Philip E. Mirkes

Publikováno v: Toxicological Sciences. 95:257-269

Hyperthermia (HS) and 4-hydroperoxycyclophosphamide (4CP) activate the mitochondrial apoptotic pathway in day 9 mouse embryos. Previous microarray analyses Microarray analyses revealed that several p53 target genes are upregulated after exposure to H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caaa3fcd12a22aa85512fb14d154b8bb
https://doi.org/10.1093/toxsci/kfl143

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Proteomics in developmental toxicology

Autor: Philip E. Mirkes, Marianne Barrier

Publikováno v: Reproductive Toxicology. 19:291-304

The objective of this presentation is to review the major proteomic technologies available to developmental toxicologists and, when possible, to provide examples of how various proteomic technologies have been used in developmental toxicology or toxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beb73f4c2d46f3e0305fd48fb2305e1f
https://doi.org/10.1016/j.reprotox.2004.09.001

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Teratogen-induced activation of the mitochondrial apoptotic pathway in the yolk sac of day 9 mouse embryos

Autor: Donna Soleman, Philip E. Mirkes, Sally A. Little, Leanne Cornel

Publikováno v: Birth Defects Research Part A: Clinical and Molecular Teratology. 67:98-107

BACKGROUND Using vital dyes, we have previously shown that while hyperthermia (HS), 4-hydroperoxycyclophosphamide (4CP), and staurosporine (ST) induce cell death within specific tissues (e.g., neuroepithelium) of day 9 mouse embryos, cells of the hea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4d90849a3241c0bb93f3d07a2d407a
https://doi.org/10.1002/bdra.10005

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Developmental toxicology in the 21st century: Multidisciplinary approaches using model organisms and genomics

Autor: Miriam Sander, Jerrold J. Heindel, Michael E. McClure, Philip E. Mirkes

Publikováno v: Birth Defects Research Part A: Clinical and Molecular Teratology. 67:21-34

Keywords: developmental toxicology; developmental biology; signal transduction pathways; genomics; proteomics; model organisms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97785a03f7b6b783aed32a550b75f93c
https://doi.org/10.1002/bdra.10024

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Teratogen-Induced Activation of Caspase-9 and the Mitochondrial Apoptotic Pathway in Early Postimplantation Mouse Embryos

Autor: Philip E. Mirkes, Sally A. Little

Publikováno v: Toxicology and Applied Pharmacology. 181:142-151

Previously we showed that teratogen-induced cell death in mouse embryos is apoptotic in nature, i.e., involves the release of cytochrome c from mitochondria and the subsequent activation of caspase-3, cleavage of poly (ADP-ribose) polymerase (PARP),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::253e59014841bf805db197d761449755
https://doi.org/10.1006/taap.2002.9414

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2001 Warkany lecture: To die or not to die, the role of apoptosis in normal and abnormal mammalian development

Autor: Philip E. Mirkes

Publikováno v: Teratology. 65:228-239

Cell death is a common and reproducible feature of the development of many mammalian tissues/organs. Two well-known examples of programmed cell death (PCD) are the cell deaths associated with fusion of the neural folds and removal of interdigital mes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::173850628a8dc4b925ce87e596614aa6
https://doi.org/10.1002/tera.10049

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Cytochrome c Release from Mitochondria of Early Postimplantation Murine Embryos Exposed to 4-Hydroperoxycyclophosphamide, Heat Shock, and Staurosporine

Autor: Sally A. Little, Philip E. Mirkes

Publikováno v: Toxicology and Applied Pharmacology. 162:197-206

Cell death is an early and common event in the pathogenesis associated with the abnormal development induced by a variety of teratogens. Previously, we showed that the cell death induced in day 9 mouse embryos by three teratogens, hyperthermia (HS),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9baafa9704fce04cab85ed9e978f6aa0
https://doi.org/10.1006/taap.1999.8849

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