Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Philip E. Hass"'
Autor:
Nadia Martinez-Martin, Sree R. Ramani, Jason A. Hackney, Irene Tom, Bernd J. Wranik, Michelle Chan, Johnny Wu, Maciej T. Paluch, Kentaro Takeda, Philip E. Hass, Hilary Clark, Lino C. Gonzalez
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Viruses interact with their hosts via secreted and membrane-bound proteins to affect host immune responses and virulence. Here the authors contribute to our understanding of this relationship with an extracellular interaction map of human and adenovi
Externí odkaz:
https://doaj.org/article/1b4ecb9936424c34966440c431fc385a
Autor:
Nadia Martinez-Martin, Sree R. Ramani, Jason A. Hackney, Irene Tom, Bernd J. Wranik, Michelle Chan, Johnny Wu, Maciej T. Paluch, Kentaro Takeda, Philip E. Hass, Hilary Clark, Lino C. Gonzalez
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-3 (2017)
Nature Communications 7: Article number: 11473 (2016); Published: 5 May 2016; Updated: 21 August 2017 In Supplementary Fig. 3 of this Article, the sequence given for CR1B_HAdV-D19a in the alignment shown is incorrect, and should have been identical t
Externí odkaz:
https://doaj.org/article/2d3d3dc9d58a457a8a3707bac95a3833
Autor:
Minhong Yan, Jayme Franklin, Philip E. Hass, Maciej Paluch, John Brady Ridgway, Jane Ruppel, Siao Ping Tsai, Ryan Cook, Sarajane Ross, Sharon Yee, Gary Cain, Krishna P. Allamneni, Jacqueline Tarrant, Nicholas Lewin-Koh, Amrita V. Kamath, Priyanka Gupta, Christina L. Zuch de Zafra, Joseph C. Beyer, Gu Zhang, Jessica A. Couch
Supplemental Methods: including HUVEC fibrin gel bead assay, Production of anti-DLL4 F(ab')2, Mouse neonatal retina assay, Xenograft tumor models, Histological analysis of mouse liver, PK assay methods, and Anti-therapeutic antibody assay method. Tab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e3f0590c39fca49455db48a58b8d59b
https://doi.org/10.1158/1078-0432.22459589
https://doi.org/10.1158/1078-0432.22459589
Autor:
Minhong Yan, Jayme Franklin, Philip E. Hass, Maciej Paluch, John Brady Ridgway, Jane Ruppel, Siao Ping Tsai, Ryan Cook, Sarajane Ross, Sharon Yee, Gary Cain, Krishna P. Allamneni, Jacqueline Tarrant, Nicholas Lewin-Koh, Amrita V. Kamath, Priyanka Gupta, Christina L. Zuch de Zafra, Joseph C. Beyer, Gu Zhang, Jessica A. Couch
Purpose: Although agents targeting Delta-like ligand 4 (DLL4) have shown great promise for angiogenesis-based cancer therapy, findings in recent studies have raised serious safety concerns. To further evaluate the potential for therapeutic targeting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::285f74cb4d522ad9230ef5f64f69dc9d
https://doi.org/10.1158/1078-0432.c.6524255.v1
https://doi.org/10.1158/1078-0432.c.6524255.v1
Autor:
Margaret Kenrick, Kelly M. Loyet, Peter Liu, Ashley Morando, Jeremy Good, Robert F. Kelley, Justin Scheer, Leslie J. Dickmann, Whitney Shatz, Wendy Sandoval, Teresa Davancaze, Philip E. Hass, Alyssa Morimoto
Publikováno v:
Molecular Pharmaceutics. 16:86-95
The collection of aqueous humor (phase 1 b/2 Mahalo study) from patients dosed intravitreally with anti-factor D (AFD; FCFD4514S, lampalizumab), a humanized antibody fragment previously under investigation to treat geographic atrophy (GA) secondary t
Autor:
Nan Chiang, Athena W. Wong, Joe Kansopon, Sophia Lee, Maciej Paluch, Philip E. Hass, Greg A. Lazar, Zahira Begum, Tia A. Arena, Sharon Viajar, Avinash Gill, Peng Luan, Gerald R. Nakamura
Publikováno v:
mAbs
To rapidly find “best-in-class” antibody therapeutics, it has become essential to develop high throughput (HTP) processes that allow rapid assessment of antibodies for functional and molecular properties. Consequently, it is critical to have acce
Autor:
Devin Tesar, Jacob Luoma, Kelly M. Loyet, Robert F. Kelley, Leslie J. Dickmann, Catherine Shi, Li Yi, Jacob E. Corn, Philip E. Hass, Menno van Lookeren Campagne, Nisana Andersen, Michelle Z. Dion, Katie F. Maass, Emily A. Wyatt, Whitney Shatz, Karthikan Rajagopal, Justin Scheer, Kathryn Wang, Mary Mathieu
Publikováno v:
mAbs
To date, ocular antibody therapies for the treatment of retinal diseases rely on injection of the drug into the vitreous chamber of the eye. Given the burden for patients undergoing this procedure, less frequent dosing through the use of long-acting
Autor:
Daniel Kirchhofer, Randall J. Brezski, Andrew S. Peterson, Nidhi Gupta, Xinhua Wang, Paul Moran, Benjamin Haley, Xiaohui Wen, Philip E. Hass, Amy Heidersbach, Suzie J. Scales, Maciej Paluch
Publikováno v:
J Am Soc Nephrol
Background Circulating APOL1 lyses trypanosomes, protecting against human sleeping sickness. Two common African gene variants of APOL1, G1 and G2, protect against infection by species of trypanosomes that resist wild-type APOL1. At the same time, the
Autor:
Bernd Wranik, Hilary Clark, Jason A. Hackney, Philip E. Hass, Kentaro Takeda, Maciej Paluch, Sree R. Ramani, Michelle Chan, Johnny Wu, Lino C. Gonzalez, Nadia Martinez-Martin, Irene Tom
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-3 (2017)
Nature Communications
Nature Communications
Viruses encode secreted and cell-surface expressed proteins essential to modulate host immune defenses and establish productive infections. However, to date there has been no systematic study of the extracellular interactome of any human virus. Here
Autor:
Jarrod Tremayne, Wei-Ching Liang, Nicola J. Stagg, Byoung-Chul Lee, Simon Williams, Cecile Chalouni, Steven R. Leong, Melissa Schutten, Paul Polakis, Rachana Ohri, Yan Wu, Deepak Sampath, Ivan Peng, Dongwei Li, Thinh Pham, Lisa Crocker, Eric Cheng, Ron Firestein, Philip E. Hass, Neelima Koppada, Annie Ogasawara, Andrew Polson, Helga Raab, Leslie Roth, Jason DeVoss
Publikováno v:
Molecular Pharmaceutics. 12:1717-1729
B7-H4 has been implicated in cancers of the female reproductive system and investigated for its possible use as a biomarker for cancer, but there are no preclinical studies to demonstrate that B7-H4 is a molecular target for therapeutic intervention