Dietary Emulsifiers Directly Impact Adherent-Invasive E. coli Gene Expression to Drive Chronic Intestinal Inflammation

Autor: Emilie Viennois, Alexis Bretin, Philip E. Dubé, Alexander C. Maue, Charlène J.G. Dauriat, Nicolas Barnich, Andrew T. Gewirtz, Benoit Chassaing

Publikováno v: Cell Reports, Vol 33, Iss 1, Pp 108229- (2020)

Summary: Dietary emulsifiers carboxymethylcellulose (CMC) and polysorbate-80 (P80) disturb gut microbiota, promoting chronic inflammation. Mice with minimal microbiota are protected against emulsifiers’ effects, leading us to hypothesize that these

Externí odkaz: https://doaj.org/article/294e9d95f9a74e06b8f9a1f09677ed89

Transitional Anal Cells Mediate Colonic Re-epithelialization in Colitis

Autor: Cambrian Y. Liu, Nandini Girish, Marie L. Gomez, Philip E. Dubé, M. Kay Washington, Benjamin D. Simons, D. Brent Polk

Publikováno v: Gastroenterology

BACKGROUND AND AIMS: Epithelial wound healing is compromised and represents an unleveraged therapeutic target in inflammatory bowel disease (IBD). Intestinal epithelial cells exhibit plasticity that facilitates dedifferentiation and repair during the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dea7e2f16a489b2dbe25ec15f910454
https://pubmed.ncbi.nlm.nih.gov/35288703

Anal skin-like epithelium mediates colonic wound healing

Autor: Chengyu Liu, Philip E. Dubé, Nandini Girish, Mary Kay Washington, Benjamin D. Simons, D. Polk, Gomez Ml

SummaryIntestinal epithelial wound healing, which is essential for health, is compromised and represents a therapeutic target in inflammatory bowel disease (IBD). While studies have elucidated important subpopulations of intestinal epithelial cells i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::df8bacc0b81da46cafc36fe537120660
https://doi.org/10.1101/2021.06.02.446836

Dietary Emulsifiers Directly Impact Adherent-Invasive E. coli Gene Expression to Drive Chronic Intestinal Inflammation

Autor: Benoit Chassaing, Nicolas Barnich, Emilie Viennois, Philip E. Dubé, Alexis Bretin, Alexander C. Maue, Charlène J.G. Dauriat, Andrew T. Gewirtz

Publikováno v: Cell Reports, Vol 33, Iss 1, Pp 108229-(2020)
Cell Reports
Cell Reports, 2020, 33 (1), pp.108229. ⟨10.1016/j.celrep.2020.108229⟩
Cell Reports, Elsevier Inc, 2020, 33 (1), pp.108229. ⟨10.1016/j.celrep.2020.108229⟩

Summary Dietary emulsifiers carboxymethylcellulose (CMC) and polysorbate-80 (P80) disturb gut microbiota, promoting chronic inflammation. Mice with minimal microbiota are protected against emulsifiers’ effects, leading us to hypothesize that these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90fc74e4072b6850f3bb8ced611263cc
http://www.sciencedirect.com/science/article/pii/S2211124720312183

Ruxolitinib, a JAK1/2 Inhibitor, Is Efficacious in a Novel Humanized GvHD Model Characterized By Enhanced NK, NK-T and T-Cell Engraftment

Autor: Julian Oliver, Lynn Stephens, Eduardo Huarte, Brian Long, Michael Peel, Becky Stewart, Philip Czerniak, Philip E. Dubé, Paul Smith

Publikováno v: Blood. 136:21-22

Background: Graft-versus-host disease (GvHD) is defined as a syndrome in which cells originating from a donor recognize and mount a deleterious immune response against antigens found in the immunocompromised recipient. Most humanized pre-clinical stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::86977f7b9d37c02e476359c165959d38
https://doi.org/10.1182/blood-2020-139805