Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Philip E. D. Chung"'
Autor:
Yeri Lee, Donggeon Kim, Philip E. D. Chung, Minkyeong Lee, Nahmju Kim, Jihoon Chang, Byoung Chul Lee
Publikováno v:
Ophthalmology and Therapy, Vol 13, Iss 8, Pp 2227-2242 (2024)
Abstract Introduction KNP-301 is a bi-specific fragment crystallizable region (Fc) fusion protein, which inhibits both C3b and vascular endothelial growth factor (VEGF) simultaneously for patients with late-stage age-related macular degeneration (AMD
Externí odkaz:
https://doaj.org/article/96ffc668d5bb4881a96f90552c64a4d6
Autor:
Zhe Jiang, YoungJun Ju, Amjad Ali, Philip E. D. Chung, Patryk Skowron, Dong-Yu Wang, Mariusz Shrestha, Huiqin Li, Jeff C. Liu, Ioulia Vorobieva, Ronak Ghanbari-Azarnier, Ethel Mwewa, Marianne Koritzinsky, Yaacov Ben-David, James R. Woodgett, Charles M. Perou, Adam Dupuy, Gary D. Bader, Sean E. Egan, Michael D. Taylor, Eldad Zacksenhaus
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Metastatic breast-cancer is a major cause of death in women worldwide, yet the relationship between oncogenic drivers that promote metastatic versus primary cancer is still contentious. To elucidate this relationship in treatment-naive anima
Externí odkaz:
https://doaj.org/article/141fc3ada18346a59e6af3fd9ea5bbbb
Autor:
Philip E. D. Chung, Deena M. A. Gendoo, Ronak Ghanbari-Azarnier, Jeff C. Liu, Zhe Jiang, Jennifer Tsui, Dong-Yu Wang, Xiao Xiao, Bryan Li, Adrian Dubuc, David Shih, Marc Remke, Ben Ho, Livia Garzia, Yaacov Ben-David, Seok-Gu Kang, Sidney Croul, Benjamin Haibe-Kains, Annie Huang, Michael D. Taylor, Eldad Zacksenhaus
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Pineoblastoma is a rare pediatric cancer. Here, the authors present inactivation of Rb plus p53 via a WAP-Cre transgene induces metastatic pineoblastoma resembling human disease, and using this model, predict tricyclic antidepressants as a potential
Externí odkaz:
https://doaj.org/article/8d8533d286084918a97e2d6644e11fc1
Autor:
Zhe Jiang, Huiqin Li, Stephanie A Schroer, Veronique Voisin, YoungJun Ju, Marek Pacal, Natalie Erdmann, Wei Shi, Philip E D Chung, Tao Deng, Nien‐Jung Chen, Giovanni Ciavarra, Alessandro Datti, Tak W Mak, Lea Harrington, Frederick A Dick, Gary D Bader, Rod Bremner, Minna Woo, Eldad Zacksenhaus
Publikováno v:
Paediatrics Publications
Despite extensive analysis of pRB phosphorylation in vitro, how this modification influences development and homeostasis in vivo is unclear. Here, we show that homozygous Rb∆K4 and Rb∆K7 knock-in mice, in which either four or all seven phosphoryl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aae2e6214979e7db704b97c706134c0c
https://ir.lib.uwo.ca/paedpub/1150
https://ir.lib.uwo.ca/paedpub/1150
Publikováno v:
Oncoscience
HER2(+) breast cancer (BC) is a highly aggressive subtype, affecting ~20% of BC patients. Current treatments include adjuvant or neoadjuvant chemotherapy plus anti-HER2 agents such as trastuzumab, a monoclonal antibody directed against HER2. Despite