Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Philip E. Branton"'
Autor:
Frédéric Dallaire, Sabrina Schreiner, G. Eric Blair, Thomas Dobner, Philip E. Branton, Paola Blanchette
Publikováno v:
mSphere, Vol 1, Iss 1 (2016)
ABSTRACT Human adenovirus (Ad) E1A proteins have long been known as the central regulators of virus infection as well as the major source of adenovirus oncogenic potential. Not only do they activate expression of other early viral genes, they make vi
Externí odkaz:
https://doaj.org/article/3384865bcf664ed09b505b5af535d394
Autor:
Frédéric Dallaire, Sabrina Schreiner, G. Eric Blair, Thomas Dobner, Philip E. Branton, Paola Blanchette
Publikováno v:
mSphere, Vol 1, Iss 1 (2016)
ABSTRACT The human adenovirus E4orf6/E1B55K E3 ubiquitin ligase is well known to promote viral replication by degrading an increasing number of cellular proteins that inhibit the efficient production of viral progeny. We report here a new function of
Externí odkaz:
https://doaj.org/article/c01a38eed5be44cc8477ec767683e17f
Autor:
Timra Gilson, Philip E. Branton, Mária Benkő, Mónika Z. Ballmann, Tibor Papp, Paola Blanchette, Judit J. Pénzes, Balázs Harrach
Publikováno v:
Journal of Virology. 90:7350-7367
E4orf6 proteins from all human adenoviruses form Cullin-based ubiquitin ligase complexes that, in association with E1B55K, target cellular proteins for degradation. While most are assembled with Cul5, a few utilize Cul2. BC-box motifs enable all thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccd7936ceebc53b5ff2f1e6191fbfcee
https://doi.org/10.1128/jvi.00420-16
https://doi.org/10.1128/jvi.00420-16
Autor:
Paola Blanchette, Yiwang Zhou, Anne-Claude Gingras, Morag Park, Naila Chughtai, Tina Gruosso, Jennifer F. Knight, Sidong Huang, Andreas I. Papadakis, Philip E. Branton, Melissa Z. Mui
Publikováno v:
Journal of Virology. 89:8855-8870
When expressed alone at high levels, the human adenovirus E4orf4 protein exhibits tumor cell-specific p53-independent toxicity. A major E4orf4 target is the B55 class of PP2A regulatory subunits, and we have shown recently that binding of E4orf4 inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e694e8e6fa91dfac42061dcb3517db9
https://doi.org/10.1128/jvi.03710-14
https://doi.org/10.1128/jvi.03710-14
Autor:
YiQing Lu, Paola Blanchette, Philip E. Branton, Isabelle Gamache, Jose G. Teodoro, Thomas J. Kucharski
Publikováno v:
Journal of Virology. 88:13249-13259
Adenovirus type 5 E4orf4 is a multifunctional protein that regulates viral gene expression. The activities of E4orf4 are mainly mediated through binding to protein phosphatase 2A (PP2A). E4orf4 recruits target phosphoproteins into complexes with PP2A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::193b53a48a7dcd4e1a2ee17997e1bccd
https://doi.org/10.1128/jvi.00933-14
https://doi.org/10.1128/jvi.00933-14
Analysis of the Cullin Binding Sites of the E4orf6 Proteins of Human Adenovirus E3 Ubiquitin Ligases
Publikováno v:
Journal of Virology. 88:3885-3897
E4orf6 proteins of human adenoviruses form Cullin-based E3 ubiquitin ligase complexes that degrade cellular proteins, which impedes efficient viral replication. These complexes also include the viral E1B55K product, which is believed to recruit most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcba22e66d7c2a537bd5d3680f749956
https://doi.org/10.1128/jvi.03579-13
https://doi.org/10.1128/jvi.03579-13
Autor:
Jose G. Teodoro, Paola Blanchette, Melissa Z. Mui, Lauriane Cabon, Philip E. Branton, Neera Sriskandarajah
Publikováno v:
Journal of Virology. 87:13168-13178
The adenovirus E4orf4 protein selectively kills human cancer cells independently of p53 and thus represents a potentially promising tool for the development of novel antitumor therapies. Previous studies suggested that E4orf4 induces an arrest or a d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbea13347cc0fef9ae11b06700b79bdc
https://doi.org/10.1128/jvi.01242-13
https://doi.org/10.1128/jvi.01242-13
Autor:
Chi Ying Cheng, Paola Blanchette, Sabrina Schreiner, Thomas Dobner, Gary Ketner, Philip E. Branton, Peter Wimmer, Timra Gilson
Publikováno v:
Journal of Virology. 87:6232-6245
The E4orf6 protein of serotypes representing all human adenovirus species forms Cullin-based E3 ubiquitin ligase complexes that facilitate virus infection by inducing degradation of cellular proteins that impede efficient viral replication. This comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a6ee7dd5c42bc211b2c973660e25727
https://doi.org/10.1128/jvi.00384-13
https://doi.org/10.1128/jvi.00384-13
Publikováno v:
Journal of Virology. 87:4872-4881
Much of the work on the basic molecular biology of human adenoviruses has been carried out on a very limited number of the more than 60 serotypes, primarily the highly related species C viruses adenovirus type 5 (Ad5) and Ad2 and, to some extent, Ad1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::326bb5f328e1ab1c54640352a5b596b5
https://doi.org/10.1128/jvi.03272-12
https://doi.org/10.1128/jvi.03272-12
Autor:
Philip E. Branton, Sabrina Schreiner, Paola Blanchette, Thomas Dobner, G. Eric Blair, Frédéric Dallaire
Publikováno v:
mSphere 1:e00014-15 (2015)
mSphere, Vol 1, Iss 1 (2016)
mSphere
mSphere, Vol 1, Iss 1 (2016)
mSphere
During the course of work on the adenovirus E3 ubiquitin ligase formed by the viral E4orf6 and E1B55K proteins, we found, very surprisingly, that expression of these species was sufficient to permit low levels of replication of an adenovirus vector l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e8d228350b53d4bf71a450569ce6bd
https://doi.org/10.1128/msphere.00014-15
https://doi.org/10.1128/msphere.00014-15