Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Philip E Schaner"'
Autor:
Philip E. Schaner, Ly-Binh-An Tran, Bassem I. Zaki, Harold M. Swartz, Eugene Demidenko, Benjamin B. Williams, Alan Siegel, Periannan Kuppusamy, Ann Barry Flood, Bernard Gallez
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract During a first-in-humans clinical trial investigating electron paramagnetic resonance tumor oximetry, a patient injected with the particulate oxygen sensor Printex ink was found to have unexpected fluorodeoxyglucose (FDG) uptake in a dermal
Externí odkaz:
https://doaj.org/article/64f07c0a11434748a2d9a0bd74b7764a
Autor:
Philip E. Schaner, Benjamin B. Williams, Eunice Y. Chen, Jason R. Pettus, Wilson A. Schreiber, Maciej M. Kmiec, Lesley A. Jarvis, David A. Pastel, Rebecca A. Zuurbier, Roberta M. DiFlorio-Alexander, Joseph A. Paydarfar, Benoit J. Gosselin, Richard J. Barth, Kari M. Rosenkranz, Sergey V. Petryakov, Huagang Hou, Dan Tse, Alexandre Pletnev, Ann Barry Flood, Victoria A. Wood, Kendra A. Hebert, Robyn E. Mosher, Eugene Demidenko, Harold M. Swartz, Periannan Kuppusamy
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
ObjectiveThe overall objective of this clinical study was to validate an implantable oxygen sensor, called the ‘OxyChip’, as a clinically feasible technology that would allow individualized tumor-oxygen assessments in cancer patients prior to and
Externí odkaz:
https://doaj.org/article/2ffb9d447e744139bf8b14916833cd47
Autor:
Philip E. Schaner, Jason R. Pettus, Ann Barry Flood, Benjamin B. Williams, Lesley A. Jarvis, Eunice Y. Chen, David A. Pastel, Rebecca A. Zuurbier, Roberta M. diFlorio-Alexander, Harold M. Swartz, Periannan Kuppusamy
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Introduction: Tumor hypoxia confers both a poor prognosis and increased resistance to oncologic therapies, and therefore, hypoxia modification with reliable oxygen profiling during anticancer treatment is desirable. The OxyChip is an implantable oxyg
Externí odkaz:
https://doaj.org/article/9e88f8dc836d4c73b0b610ee7ca81ed8
Autor:
Harold M. Swartz, Ann Barry Flood, Philip E. Schaner, Howard Halpern, Benjamin B. Williams, Brian W. Pogue, Bernard Gallez, Peter Vaupel
Publikováno v:
Physiological Reports, Vol 8, Iss 15, Pp n/a-n/a (2020)
Abstract It is well understood that the level of molecular oxygen (O2) in tissue is a very important factor impacting both physiology and pathological processes as well as responsiveness to some treatments. Data on O2 in tissue could be effectively u
Externí odkaz:
https://doaj.org/article/6035f9f4fb374398905bf2125f7fe4df
Autor:
Benjamin B. Williams, Periannan Kuppusamy, Sassan Hodge, Kendra A. Hebert, Philip E. Schaner, Dan Tse, Maciej M. Kmiec
Publikováno v:
Magn Reson Med
PURPOSE Electron paramagnetic resonance oximetry using the OxyChip as an implantable oxygen sensor can directly and repeatedly measure tissue oxygen levels. A phase I, first-in-human clinical study has established the safety and feasibility of using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5719454b9ed0399e2ba6ab9b1c56b5ad
https://doi.org/10.1002/mrm.29039
https://doi.org/10.1002/mrm.29039
Autor:
Harold M. Swartz, Benjamin B. Williams, Maciej M. Kmiec, Periannan Kuppusamy, Philip E. Schaner, Wilson Schreiber, Sergey Petryakov
Publikováno v:
Applied Magnetic Resonance. 53:145-165
There is a strong need to enable accurate and convenient oxygen measurements in vivo for human subjects to improve treatments for cancer, peripheral vascular disease, and other diseases where tissue oxygen levels have a significant impact. While EPR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3623fff75097d4201a2c649e1f9b3e58
https://doi.org/10.1007/s00723-021-01408-0
https://doi.org/10.1007/s00723-021-01408-0
Autor:
Philip E. Schaner, Benjamin B. Williams, Ann Barry Flood, Sergey Petryakov, Maciej M. Kmiec, Wilson Schreiber, Harold M. Swartz
Publikováno v:
Applied Magnetic Resonance. 53:123-143
EPR spectrometers (and various sub-systems) have been designed and constructed to facilitate in vivo measurements with human subjects for dosimetry and oximetry. Most applications are primarily focused on surface tissue measurements; however, oximetr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6c245e8be193767d7e92fde3efa1521
https://doi.org/10.1007/s00723-021-01382-7
https://doi.org/10.1007/s00723-021-01382-7
Autor:
Huagang Hou, Wilson Schreiber, Benjamin B. Williams, Kendra A. Hebert, Harold M. Swartz, Maciej M. Kmiec, Periannan Kuppusamy, Dan Tse, Philip E. Schaner, Eunice Y. Chen
Publikováno v:
Appl Magn Reson
OBJECTIVES: (1) Summarize revisions made to the implantable resonator (IR) design and results of testing to characterize biocompatibility; (2) Demonstrate safety of implantation and feasibility of deep tissue oxygenation measurement using electron pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2067dd6f7aa71c190570a8fe48326cc4
https://pubmed.ncbi.nlm.nih.gov/34744319
https://pubmed.ncbi.nlm.nih.gov/34744319
Autor:
Benjamin B. Williams, Eugene Demidenko, Periannan Kuppusamy, Philip E. Schaner, Alan Siegel, Bernard Gallez, Harold M. Swartz, Bassem I. Zaki, Ann Barry Flood, Ly-Binh-An Tran
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
During a first-in-humans clinical trial investigating electron paramagnetic resonance tumor oximetry, a patient injected with the particulate oxygen sensor Printex ink was found to have unexpected fluorodeoxyglucose (FDG) uptake in a dermal nodule vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fc673843810acfe8073d6bbe4528d45
https://doi.org/10.1038/s41598-021-82754-8
https://doi.org/10.1038/s41598-021-82754-8
Autor:
Benjamin B. Williams, Peter Vaupel, Ann Barry Flood, Brian W. Pogue, Harold M. Swartz, Philip E. Schaner
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9783030482367
Clinical measurements of O2 in tissues will inevitably provide data that are at best aggregated and will not reflect the inherent heterogeneity of O2 in tissues over space and time. Additionally, the nature of all existing techniques to measure O2 re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bce2ffcbd5e8e99d07706d832ad50a58
https://doi.org/10.1007/978-3-030-48238-1_48
https://doi.org/10.1007/978-3-030-48238-1_48
