Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Philip E Boucher"'
Publikováno v:
PLoS Pathogens, Vol 16, Iss 5, p e1008500 (2020)
Pertussis toxin is the preeminent virulence factor and major protective antigen produced by Bordetella pertussis, the human respiratory pathogen and etiologic agent of whooping cough. Genes for its synthesis and export are encoded by the 12 kb ptx-pt
Externí odkaz:
https://doaj.org/article/8de95db5f5e54968849b85d3c2c4decf
Publikováno v:
Molecular Microbiology. 77:1326-1340
Summary A prominent feature of the promoters of Bordetella pertussis fimbrial subunit genes fim2, fim3 and fimX is the presence of a ‘C-stretch’, a monotonic run of C residues. The C-stretch renders these genes capable of phase variation, through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b29e11fc58503e8efb9dadc2b6f4942d
https://doi.org/10.1111/j.1365-2958.2010.07293.x
https://doi.org/10.1111/j.1365-2958.2010.07293.x
Publikováno v:
Molecular Microbiology. 58:700-713
Summary To investigate the mechanism by which the Bordetella BvgAS phosphorelay controls expression of at least three distinct phenotypic phases, we isolated and characterized two B. pertussis mutants that were able to express Bvg - and Bvg i phase p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a26ae23bf3136a70c4d6395ff2140067
https://doi.org/10.1111/j.1365-2958.2005.04875.x
https://doi.org/10.1111/j.1365-2958.2005.04875.x
Publikováno v:
Molecular Microbiology. 56:175-188
The Bordetella bipA gene is expressed maximally when the BvgAS phosphorelay is semi-active, i.e. in the Bvg-intermediate (Bvg(i)) phase. We used a BvgA-FeBABE cleavage approach together with site-directed mutagenesis and bipA-lacZ fusion analyses to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bb86f1df49e1246228c68413bcfcbe0
https://doi.org/10.1111/j.1365-2958.2004.04526.x
https://doi.org/10.1111/j.1365-2958.2004.04526.x
Publikováno v:
Molecular Microbiology. 40:991-999
In order to define a consensus binding sequence for the response regulator BvgA, we have undertaken a systematic analysis of contributions made by each nucleotide within the heptad half-sites that are present in an inverted orientation at the promote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3e19df33ad0f452ec7a5fb3dcd408b8
https://doi.org/10.1046/j.1365-2958.2001.02442.x
https://doi.org/10.1046/j.1365-2958.2001.02442.x
Publikováno v:
Journal of Bacteriology. 183:536-544
The BvgA-BvgS two-component signal transduction system regulates expression of virulence factors in Bordetella pertussis . The BvgA response regulator activates transcription by binding to target promoters, which include those for the genes encoding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f685ced45a798b360f7c284d1ce54445
https://doi.org/10.1128/jb.183.2.536-544.2001
https://doi.org/10.1128/jb.183.2.536-544.2001
Publikováno v:
Journal of Bacteriology. 181:5234-5241
Bordetella pertussis , the causative agent of whooping cough, regulates expression of its virulence factors via a two-component signal transduction system encoded by the bvg regulatory locus. It has been shown by activation kinetics that several of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aaf72fe79dc29e1e118ab578fb2104f
https://doi.org/10.1128/jb.181.17.5234-5241.1999
https://doi.org/10.1128/jb.181.17.5234-5241.1999
Autor:
Mark Mayhew, Alan N. Houghton, Flora Castellino, Ronald N. Germain, Philip E. Boucher, Katrin Eichelberg, James E. Rothman
Publikováno v:
The Journal of Experimental Medicine
Heat shock proteins (HSPs) derived from tumors or virally infected cells can stimulate antigen-specific CD8+ T cell responses in vitro and in vivo. Although this antigenicity is known to arise from HSP-associated peptides presented to the immune syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c5d1a2abba2bc71485f41058dbef530
https://doi.org/10.1084/jem.191.11.1957
https://doi.org/10.1084/jem.191.11.1957
Publikováno v:
Journal of Bacteriology. 179:1755-1763
The expression of virulence factor genes in Bordetella pertussis is mediated by the BvgA-BvgS two-component signal transduction system. The response regulator, BvgA, acts directly as a transcriptional activator at the loci encoding pertussis toxin (p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d023a02c52032e8107ee336552680c7
https://doi.org/10.1128/jb.179.5.1755-1763.1997
https://doi.org/10.1128/jb.179.5.1755-1763.1997
Autor:
Kimberly Baxter Decker, Deborah M. Hinton, Philip E. Boucher, Qing Chen, Meng-Lun Hsieh, Scott Stibitz
Bordetella pertussis BvgA is a global response regulator that activates virulence genes, including adhesin-encoding fim3 and fhaB. At the fhaB promoter, P(fhaB), a BvgA binding site lies immediately upstream of the -35 promoter element recognized by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ff178d8dbe18a4b33358497c30b229a
https://europepmc.org/articles/PMC3141349/
https://europepmc.org/articles/PMC3141349/
