Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Philip E, Auron"'
Autor:
Daniela N. Petrusca, Patrick L. Mulcrone, David A. Macar, Ryan T. Bishop, Evgeny Berdyshev, Attaya Suvannasankha, Judith L. Anderson, Quanhong Sun, Philip E. Auron, Deborah L. Galson, G. David Roodman
Publikováno v:
Cancers, Vol 14, Iss 3, p 772 (2022)
Multiple myeloma (MM) remains incurable for most patients due to the emergence of drug resistant clones. Here we report a p53-independent mechanism responsible for Growth Factor Independence-1 (GFI1) support of MM cell survival by its modulation of s
Externí odkaz:
https://doaj.org/article/e72e41a02a6a4c6a8e7f4c556138a6ce
Autor:
Peng Zhang, David A. Macar, Quanhong Sun, Deborah L. Galson, Sree H Pulugulla, Juraj Adamik, Philip E. Auron, Konstantinos Lontos
Publikováno v:
J Bone Miner Res
Key osteoclast (OCL) regulatory gene promoters in bone marrow-derived monocytes harbor bivalent histone modifications that combine activating Histone 3 lysine 4 tri-methyl (H3K4me3) and repressive H3K27me3 marks, which upon RANKL stimulation resolve
Autor:
Daniela N, Petrusca, Patrick L, Mulcrone, David A, Macar, Ryan T, Bishop, Evgeny, Berdyshev, Attaya, Suvannasankha, Judith L, Anderson, Quanhong, Sun, Philip E, Auron, Deborah L, Galson, G David, Roodman
Publikováno v:
Cancers. 14(3)
Multiple myeloma (MM) remains incurable for most patients due to the emergence of drug resistant clones. Here we report a p53-independent mechanism responsible for Growth Factor Independence-1 (GFI1) support of MM cell survival by its modulation of s
Autor:
Emilio Xavier Esposito, Jeffry D. Madura, Juraj Adamik, Zhiyong Yang, Sree H Pulugulla, Brian Lupish, Deborah L. Galson, David A. Macar, Samir el Abdouni, Riley J. Workman, Philip E. Auron, Nathan W. Rutter, Carlos J. Camacho
Publikováno v:
Journal of Biological Chemistry. 293:19942-19956
We previously reported that transcription of the human IL1B gene, encoding the proinflammatory cytokine interleukin 1β, depends on long-distance chromatin looping that is stabilized by a mutual interaction between the DNA-binding domains (DBDs) of t
Autor:
Juraj Adamik, Gilad Doitsh, Warner C. Greene, Deborah L. Galson, Nicole L. K. Galloway, Sree H Pulugulla, Philip E. Auron, Thomas A. Packard, Zachary W. Grimmett
Publikováno v:
Cytokine. 111:373-381
Interleukin 1β is a pro-inflammatory cytokine important for both normal immune responses and chronic inflammatory diseases. The regulation of the 31 kDa proIL-1β precursor coded by the IL1B gene has been extensively studied in myeloid cells, but no
Autor:
Juraj Adamik, Kent Z Q Wang, Sebnem Unlu, An-Jey A Su, Gillian M Tannahill, Deborah L Galson, Luke A O'Neill, Philip E Auron
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70622 (2013)
Interleukin-1β and Tumor Necrosis Factor α play related, but distinct, roles in immunity and disease. Our study revealed major mechanistic distinctions in the Toll-like receptor (TLR) signaling-dependent induction for the rapidly expressed genes (I
Externí odkaz:
https://doaj.org/article/d6aa7508b0234904a188fdc251d14e52
Autor:
Philip E. Auron, Brionna Nelson, McKenna Ringling, Bariushaa Munkhtsog, Brian M. Davis, Jan E. Janecka, Rodney M. Jackson, Shafqat Hussain, Jennifer Broderick, Sree H Pulugulla, Charlotte E. Hacker
Publikováno v:
Conservation Genetics in Mammals ISBN: 9783030333331
Noninvasive genetic methods and genomics have been able to provide important insights into the distribution, ecology, and evolution of the snow leopard. Scat sampling has yielded quantitative population size estimates using surveys that can be implem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c771cdb51531019b53144bd9c1b08b09
https://doi.org/10.1007/978-3-030-33334-8_5
https://doi.org/10.1007/978-3-030-33334-8_5
Publikováno v:
PLoS Computational Biology, Vol 3, Iss 3, p e61 (2007)
Transcription factor (TF) proteins recognize a small number of DNA sequences with high specificity and control the expression of neighbouring genes. The evolution of TF binding preference has been the subject of a number of recent studies, in which g
Externí odkaz:
https://doaj.org/article/984debeb6a7141db80e527793ade33c2
Autor:
Sree H, Pulugulla, Riley, Workman, Nathan W, Rutter, Zhiyong, Yang, Juraj, Adamik, Brian, Lupish, David A, Macar, Samir, El Abdouni, Emilio Xavier, Esposito, Deborah L, Galson, Carlos J, Camacho, Jeffry D, Madura, Philip E, Auron
Publikováno v:
The Journal of biological chemistry. 293(52)
We previously reported that transcription of the human IL1B gene, encoding the proinflammatory cytokine interleukin 1β, depends on long-distance chromatin looping that is stabilized by a mutual interaction between the DNA-binding domains (DBDs) of t