Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Philip Diiorio"'
Autor:
Chaoxing Yang, Agata Jurczyk, Philip diIorio, Elaine Norowski, Michael A Brehm, Christian W Grant, Dennis L Guberski, Dale L Greiner, Rita Bortell
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78050 (2013)
Epidemiologic and clinical evidence suggests that virus infection plays an important role in human type 1 diabetes pathogenesis. We used the virus-inducible BioBreeding Diabetes Resistant (BBDR) rat to investigate the ability of sodium salicylate, a
Externí odkaz:
https://doaj.org/article/10866a00990e4432ba57fc70af044e2e
Autor:
Agata Jurczyk, Steven C Pino, Bryan O'Sullivan-Murphy, Martha Addorio, Erich A Lidstone, Philip Diiorio, Kathryn L Lipson, Clive Standley, Kevin Fogarty, Lawrence Lifshitz, Fumihiko Urano, John P Mordes, Dale L Greiner, Aldo A Rossini, Rita Bortell
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11812 (2010)
The centrosome is important for microtubule organization and cell cycle progression in animal cells. Recently, mutations in the centrosomal protein, pericentrin, have been linked to human microcephalic osteodysplastic primordial dwarfism (MOPD II), a
Externí odkaz:
https://doaj.org/article/87eb60336d2e4579be48ca104bae968e
Autor:
Steven C Pino, Bryan O'Sullivan-Murphy, Erich A Lidstone, Chaoxing Yang, Kathryn L Lipson, Agata Jurczyk, Philip diIorio, Michael A Brehm, John P Mordes, Dale L Greiner, Aldo A Rossini, Rita Bortell
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5468 (2009)
Gimap5 (GTPase of the immunity-associated protein 5) has been linked to the regulation of T cell survival, and polymorphisms in the human GIMAP5 gene associate with autoimmune disorders. The BioBreeding diabetes-prone (BBDP) rat has a mutation in the
Externí odkaz:
https://doaj.org/article/b47c27fdea4649c3bca3dcc7d7cff892
Autor:
David M. Blodgett, Natalia Przewozniak, David M. Harlan, Anetta Nowosielska, Dale L. Greiner, Agata Jurczyk, Martha Campbell-Thompson, Ann R. Rittenhouse, Philip diIorio, Mark A. Atkinson, Ken-Edwin Aryee, Chaoxing Yang, Rita Bortell, Leonard D. Shultz
Publikováno v:
The FASEB Journal. 30:983-993
Individuals with schizophrenia and their first-degree relatives have higher rates of type 2 diabetes (T2D) than the general population (18–30 vs. 1.2–6.3%), independent of body mass index and antipsychotic medication, suggesting shared genetic co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b3fe3eeb8646d4927aea08de2bc4775
https://doi.org/10.1096/fj.15-279810
https://doi.org/10.1096/fj.15-279810
Publikováno v:
Birth Defects Research Part C: Embryo Today: Reviews. 102:126-138
Primary cilia play an essential role in modulating signaling cascades that shape cellular responses to environmental cues to maintain proper tissue development. Mutations in primary cilium proteins have been linked to several rare developmental disor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15e389db36d3cfb537051e3e37bfa38e
https://doi.org/10.1002/bdrc.21064
https://doi.org/10.1002/bdrc.21064
Autor:
Felicia W. Pagliuca, Douglas A. Melton, Charles W. O'Donnell, Philip diIorio, Francis Deng, Alireza Rezania, David K. Gifford, Sinisa Hrvatin, Jeffrey R. Millman
Publikováno v:
Proceedings of the National Academy of Sciences. 111:3038-3043
Human pluripotent stem cells (hPSCs) have the potential to generate any human cell type, and one widely recognized goal is to make pancreatic β cells. To this end, comparisons between differentiated cell types produced in vitro and their in vivo cou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7675477dc4d63783c65c027431453c05
https://doi.org/10.1073/pnas.1400709111
https://doi.org/10.1073/pnas.1400709111
Autor:
Agata Jurczyk, Rita Bortell, Bryan O'Sullivan-Murphy, Chaoxing Yang, Fumihiko Urano, Philip diIorio
Publikováno v:
Diabetologia. 56:2638-2646
We hypothesised that pathological endoplasmic reticulum (ER) stress contributes to beta cell death during development of type 1 diabetes. In this study, we investigated the occurrence of beta cell ER stress and the signalling pathways involved during
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7d0027e9ba90ab8110c3cb5d9995ad3
https://doi.org/10.1007/s00125-013-3044-4
https://doi.org/10.1007/s00125-013-3044-4
Autor:
Dale L. Greiner, Alvin C. Powers, Lisa M. Burzenski, M.M. Herlihy, Philip diIorio, Bruce Gott, Joseph Laning, Oded Foreman, Chaoxing Yang, Leonard D. Shultz, Michael A. Brehm, Jean Leif, Amy Cuthbert, Rita Bortell
Publikováno v:
Diabetes
OBJECTIVE To create an immunodeficient mouse model that spontaneously develops hyperglycemia to serve as a diabetic host for human islets and stem cell–derived β-cells in the absence or presence of a functional human immune system. RESEARCH DESIGN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e56a6f5a72a01f0dc57007aa426a22ae
https://doi.org/10.2337/db10-0323
https://doi.org/10.2337/db10-0323
Autor:
Dale L. Greiner, Oded Foreman, Michael A. Brehm, Bruce Gott, Lisa M. Burzenski, J Laning, David Miller, Amy Cuthbert, Philip diIorio, Aldo A. Rossini, Chaoxing Yang, Leonard D. Shultz, Anoop Kavirayani, M.M. Herlihy
Publikováno v:
Clinical Immunology. 135:84-98
"Humanized" mouse models created by engraftment of immunodeficient mice with human hematolymphoid cells or tissues are an emerging technology with broad appeal across multiple biomedical disciplines. However, investigators wishing to utilize humanize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb372d63174bc1d94c6124238cdb93d4
https://doi.org/10.1016/j.clim.2009.12.008
https://doi.org/10.1016/j.clim.2009.12.008
Publikováno v:
Developmental Biology. 304:221-231
sonic hedgehog (shh) is expressed in anterior endoderm, where it is required to repress pancreas gene expression and to pattern the endoderm, but the pathway controlling endodermal shh expression is unclear. We find that expression of meis3, a TALE c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc07def7390d9b76edd56daea7f4e28b
https://doi.org/10.1016/j.ydbio.2006.12.024
https://doi.org/10.1016/j.ydbio.2006.12.024