Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Philip D. Ray"'
Autor:
R Clay Bunn, Reuben Adatorwovor, Rebecca R Smith, Philip D Ray, Sarah E Fields, Alexander R Keeble, Christopher S Fry, Sasidhar Uppuganti, Jeffry S Nyman, John L Fowlkes, Evangelia Kalaitzoglou
Publikováno v:
JBMR Plus, Vol 7, Iss 11, Pp n/a-n/a (2023)
ABSTRACT Type 1 diabetes (T1D) is associated with low bone and muscle mass, increased fracture risk, and impaired skeletal muscle function. Myostatin, a myokine that is systemically elevated in humans with T1D, negatively regulates muscle mass and bo
Externí odkaz:
https://doaj.org/article/92100dade6de4c38b7555d341607541a
Autor:
Kathryn M. Thrailkill, Sasidhar Uppuganti, John L. Fowlkes, Jacquelyn S. Pennings, Kate Garrett, Jeffry S. Nyman, Iuliana Popescu, Philip D. Ray, R. Clay Bunn
Publikováno v:
Bone
Selective sodium-dependent glucose co-transporter 2 inhibitors (SGLT2Is) are oral hypoglycemic medications utilized increasingly in the medical management of hyperglycemia among persons with type 2 diabetes (T2D). Despite favorable effects on cardiov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6448f26cb215c87ea6840ab38640c54
https://europepmc.org/articles/PMC7059549/
https://europepmc.org/articles/PMC7059549/
Publikováno v:
Journal of the Endocrine Society
Selective sodium-dependent glucose co-transporter 2 inhibitors (SGLT2is) are a class of anti-hyperglycemic drugs that lower blood glucose in an insulin-independent manner by inhibiting renal glucose reabsorption and promoting glucosuria. In persons w
Autor:
Evangelia Kalaitzoglou, R. Clay Bunn, John L. Fowlkes, Kathryn M. Thrailkill, Jeffry S. Nyman, Sasidhar Uppuganti, Iuliana Popescu, Philip D. Ray
Publikováno v:
Diabetes. 68
Higher fracture risk in T2D is attributed to disease specific deficits in micro-structural and material properties of bone. The TallyHO (TH) mouse is a polygenic model of early-onset T2D/obesity analogous to adolescent-onset T2D in humans. Male TH mi
Autor:
Evangelia Kalaitzoglou, Philip D. Ray, Jeffry S. Nyman, John L. Fowlkes, Sasidhar Uppuganti, Iuliana Popescu, Kathryn M. Thrailkill, R. Clay Bunn
Publikováno v:
Bone
Higher fracture risk in type 2 diabetes (T2D) is attributed to disease-specific deficits in micro-structural and material properties of bone, although the primary cause is not yet established. The TallyHO (TH) mouse is a polygenic model of early-onse
Autor:
R. Clay Bunn, Sasidhar Uppuganti, Kathryn M. Thrailkill, Philip D. Ray, John L. Fowlkes, Evangelia Kalaitzoglou, Jeffry S. Nyman, Mustafa Unal
Publikováno v:
Bone
Recent clinical studies have revealed that a somatic mutation in MAP2K1, causing constitutive activation of MEK1 in osteogenic cells, occurs in melorheostotic bone disease in humans. We have generated a mouse model which expresses an activated form o
Autor:
Dibakar Bhattacharyya, Avindra Nath, David Galey, Aaron M. Hollman, David A. Christian, Philip D. Ray, Jadwiga Turchan
Publikováno v:
Biotechnology Progress. 21:451-459
This work deals with the separation of Tat protein from a complex fermentation broth using an affinity membrane system. Tat is a regulatory protein that is critical for HIV-1 replication and thus a potential candidate for vaccine and drug development
Publikováno v:
Separation Science and Technology. 42:2451-2471
The isolation and purification of Tat protein from bacterial lysate using avidin‐biotin interaction in microfiltration membranes have been reported in the literature. To increase the efficacy of the technique, improvements in flux, Tat separation e
Publikováno v:
Journal of Membrane Science. 280:298-310
Recognition based separation using modified microfiltration membranes provides an efficient and cost-effective alternative to conventional column chromatography for the separation and purification of a specific protein from mixture of proteins. In th
Autor:
Charles F. Mactutus, Marina V. Aksenova, Avindra Nath, Janelle M. Silvers, Michael Y. Aksenov, Philip D. Ray, Rosemarie M. Booze
Publikováno v:
Neuroscience letters. 395(3)
HIV-1 neurotoxic proteins (Tat, gp120) are believed to play a major role in pathogenesis of dementia in a significant portion of the AIDS patient population. Dopaminergic systems appear to be particularly important in HIV-associated dementia. In the