Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Philip D. Mosier"'
Autor:
Irina Etobayeva, Sara B. Linden, Farhang Alem, Laith Harb, Lucas Rizkalla, Philip D. Mosier, Allison A. Johnson, Louise Temple, Ramin M. Hakami, Daniel C. Nelson
Publikováno v:
Viruses, Vol 10, Iss 5, p 276 (2018)
Three Bacillus bacteriophage-derived endolysins, designated PlyP56, PlyN74, and PlyTB40, were identified, cloned, purified, and characterized for their antimicrobial properties. Sequence alignment reveals these endolysins have an N-terminal enzymatic
Externí odkaz:
https://doaj.org/article/da4e3e0d67904a55911195bf81045323
Autor:
Meng-Jung Chiang, Faik N Musayev, Martina Kosikova, Zhengshi Lin, Yamei Gao, Philip D Mosier, Bashayer Althufairi, Zhiping Ye, Qibing Zhou, Umesh R Desai, Hang Xie, Martin K Safo
Publikováno v:
Emerging Microbes and Infections, Vol 6, Iss 1, Pp 1-11 (2017)
The M gene segment of influenza A virus has been shown to be a contributing factor to the high growth phenotype. However, it remains largely unknown why matrix protein 1 (M1), the major structural protein encoded by M gene, exhibits pH-dependent conf
Externí odkaz:
https://doaj.org/article/012e972efd224b868ea35d92c5d90cd6
Autor:
Giuseppe Gasparre, Marcello Leopoldo, Carmen Abate, Savina Ferorelli, Francesco Berardi, Giuseppe Cassano, Roberta Marottoli, Mauro Niso, Philip D. Mosier
Publikováno v:
Future Medicinal Chemistry. 11:2547-2562
Aim: The σ1 receptor is a druggable target involved in many physiological processes and diseases. To clarify its physiology and derive therapeutic benefit, nine analogs based on the σ1 antagonist PB212 were synthesized replacing the 4-methylpiperid
Autor:
Francesca S, Abatematteo, Philip D, Mosier, Mauro, Niso, Leonardo, Brunetti, Francesco, Berardi, Fulvio, Loiodice, Marialessandra, Contino, Benjamin, Delprat, Tangui, Maurice, Antonio, Laghezza, Carmen, Abate
Publikováno v:
European journal of medicinal chemistry. 228
The sigma-1 (σ
Autor:
Michael M. White, Osama I. Alwassil, Marvin K. Schulte, Shailesh Khatri, Ahmed S. Abdelkhalek, Heather L. Nyce, Genevieve S Alley, Malgorzata Dukat, Philip D. Mosier
Publikováno v:
ACS Chemical Neuroscience. 10:1380-1389
Arylguanidines, depending upon their aromatic substitution pattern, display varying actions at 5-HT3 receptors (e.g., partial agonist, agonist, superagonist). Here, we demonstrate that conformational constraint of these agents as dihydroquinazolines
Autor:
Francesca S. Abatematteo, Philip D. Mosier, Mauro Niso, Leonardo Brunetti, Francesco Berardi, Fulvio Loiodice, Marialessandra Contino, Benjamin Delprat, Tangui Maurice, Antonio Laghezza, Carmen Abate
Publikováno v:
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, 2022, 228, pp.114038. ⟨10.1016/j.ejmech.2021.114038⟩
European Journal of Medicinal Chemistry, 2022, 228, pp.114038. ⟨10.1016/j.ejmech.2021.114038⟩
International audience; The sigma-1 (σ1) receptor plays a significant role in many normal physiological functions and pathological disease states, and as such represents an attractive therapeutic target for both agonists and antagonists. Here, we de
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48632 (2012)
The antithrombin-heparin/heparan sulfate (H/HS) and thrombin-H/HS interactions are recognized as prototypic specific and non-specific glycosaminoglycan (GAG)-protein interactions, respectively. The fundamental structural basis for the origin of speci
Externí odkaz:
https://doaj.org/article/d33788b9c3f544ec9e9f9a78132156d4
Autor:
Mauro, Niso, Philip D, Mosier, Roberta, Marottoli, Savina, Ferorelli, Giuseppe, Cassano, Giuseppe, Gasparre, Marcello, Leopoldo, Francesco, Berardi, Carmen, Abate
Publikováno v:
Future medicinal chemistry. 11(19)
Autor:
Kevin Sheerin, Arjun Raghuraman, Umesh R. Desai, Nehru Viji Sankarayanarayanan, Florence Sallas, Philip D. Mosier, Nicholas D. Watermeyer, Stefan Oscarson, Rio S. Boothello, Tamara R. Strebel
Publikováno v:
Angewandte Chemie (International Ed. in English)
Glycosaminoglycan (GAG) sequences that selectively target heparin cofactor II (HCII), a key serpin present in human plasma, remain unknown. Using a computational strategy on a library of 46 656 heparan sulfate hexasaccharides we identified a rare seq